MAP3K14 mitogen-activated protein kinase kinase kinase 14 [Homo sapiens (human)]
| Gene Symbol | MAP3K14 |
| Entrez Gene ID | 9020 |
| Full Name | mitogen-activated protein kinase kinase kinase 14 |
| Synonyms | FTDCR1B, HS, HSNIK, NIK |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
17 17q21 |
| Summary | This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. [provided by RefSeq]. |
| Disorder | MIM: 604655 |
| mRNA | NM_003954, 115298644 |
| Protein | NP_003945, 115298645 |
| Product | mitogen-activated protein kinase kinase kinase 14 |
| RefSeq Status | REVIEWED |
| hsa04672 | Intestinal immune network for IgA production |
| hsa04010 | MAPK signaling pathway |
| hsa04380 | Osteoclast differentiation |
| hsa04210 | Apoptosis |
| hsa05120 | Epithelial cell signaling in Helicobacter pylori infection |
| hsa04660 | T cell receptor signaling pathway |
WikiPathways
| WP231 | TNF-alpha/NF-kB Signaling Pathway |
| WP1544 | MicroRNAs in cardiomyocyte hypertrophy |
| WP382 | MAPK signaling pathway |
| WP481 | Insulin Signaling |
| WP1434 | Osteopontin Signaling |
| WP437 | EGFR1 Signaling Pathway |
Pathway Interaction Database
| cd8tcrpathway | TCR signaling in naive CD8+ T cells |
| hivnefpathway | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| cd40_pathway | CD40/CD40L signaling |
| nfkappabalternativepathway | Alternative NF-kappaB pathway |
| avb3_opn_pathway | Osteopontin-mediated events |
| tcr_pathway | TCR signaling in naive CD4+ T cells |
Reactome
| REACT_19358 | CD28 dependent PI3K/Akt signaling |
| REACT_6900 | Signaling in Immune system |
| REACT_19183 | CD28 co-stimulation |
| REACT_19344 | Costimulation by the CD28 family |
| Homo sapiens (human) | MAP3K14 | NP_003945.2 |
| Canis lupus familiaris (dog) | MAP3K14 | XP_548049.2 |
| Bos taurus (cattle) | MAP3K14 | XP_585134.3 |
| Mus musculus (house mouse) | Map3k14 | NP_058592.1 |
| Rattus norvegicus (Norway rat) | Map3k14 | XP_340919.2 |
| Gallus gallus (chicken) | MAP3K14 | NP_001026098.1 |
| Danio rerio (zebrafish) | LOC100004261 | XP_002661254.1 |
| Danio rerio (zebrafish) | LOC795766 | XP_001919064.1 |
| ID | Name | Evidence |
| GO:0006468 | protein phosphorylation | IEA |
| GO:0006955 | immune response | ISS |
| GO:0007249 | I-kappaB kinase/NF-kappaB cascade | ISS |
| GO:0031295 | T cell costimulation | TAS |
| GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB cascade | IMP |
| GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB cascade | RCA |
| GO:0071260 | cellular response to mechanical stimulus | IEP |
Component
| ID | Name | Evidence |
| GO:0005737 | cytoplasm | IEA |
| GO:0005829 | cytosol | EXP |
Function
| ID | Name | Evidence |
| GO:0000166 | nucleotide binding | IEA |
| GO:0004672 | protein kinase activity | IDA |
| GO:0004674 | protein serine/threonine kinase activity | IEA |
| GO:0004704 | NF-kappaB-inducing kinase activity | ISS |
| GO:0004709 | MAP kinase kinase kinase activity | IEA |
| GO:0005515 | protein binding | IPI |
| GO:0005524 | ATP binding | IEA |
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