Sequence in raw or FASTA format:
MARCH9 membrane-associated ring finger (C3HC4) 9 [Homo sapiens (human)]
| Gene Symbol | MARCH9 |
| Entrez Gene ID | 92979 |
| Full Name | membrane-associated ring finger (C3HC4) 9 |
| Synonyms | FLJ36578, MARCH-IX, RNF179 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
12 12q14.1 |
| Summary | MARCH9 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH9 induces internalization of several membrane glycoproteins and directs them to the endosomal compartment (Bartee et al., 2004 [PubMed 14722266]; Hoer et al., 2007 [PubMed 17174307]).[supplied by OMIM]. |
| Disorder | MIM: 613336 |
| mRNA | NM_138396, 53759067 |
| Protein | NP_612405, 40255016 |
| Product | E3 ubiquitin-protein ligase MARCH9 |
| RefSeq Status | VALIDATED |
| Homo sapiens (human) | MARCH9 | NP_612405.2 |
| Bos taurus (cattle) | MARCH9 | XP_872323.1 |
| Mus musculus (house mouse) | March9 | NP_001028434.1 |
| Danio rerio (zebrafish) | si:dkey-229p15.1 | XP_001339845.1 |
| ID | Name | Evidence |
| GO:0000139 | Golgi membrane | IEA |
| GO:0005765 | lysosomal membrane | IEA |
| GO:0005794 | Golgi apparatus | IEA |
| GO:0005795 | Golgi stack | IDA |
| GO:0005802 | trans-Golgi network | IDA |
| GO:0016020 | membrane | IEA |
| GO:0016021 | integral to membrane | IEA |
Function
| ID | Name | Evidence |
| GO:0008270 | zinc ion binding | IEA |
| GO:0016874 | ligase activity | IEA |
| GO:0046872 | metal ion binding | IEA |
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