ACVR2B activin A receptor, type IIB [Homo sapiens (human)]

Gene Symbol	ACVR2B
Entrez Gene ID	93
Full Name	activin A receptor, type IIB
Synonyms	ACTRIIB, ActR-IIB, MGC116908
Gene Type	protein-coding
Organism	Homo sapiens (human)
Genome	Chromosome:3 Map Location:3p22
Summary	Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq].
Disorder	MIM: 602730 Heterotaxy, visceral, 4, autosomal (3)

mRNA	NM_001106, 116734707
Protein	NP_001097, 116734708
Product	activin receptor type-2B precursor
RefSeq Status	REVIEWED

KEGG

hsa04350	TGF-beta signaling pathway
hsa04060	Cytokine-cytokine receptor interaction

Reactome

REACT_12034

Signaling by BMP

Homo sapiens (human)	ACVR2B	NP_001097.2
Pan troglodytes (chimpanzee)	ACVR2B	XP_001171684.1
Canis lupus familiaris (dog)	ACVR2B	XP_542709.1
Bos taurus (cattle)	ACVR2B	NP_776920.1
Mus musculus (house mouse)	Acvr2b	NP_031423.1
Rattus norvegicus (Norway rat)	Acvr2b	NP_113742.1
Gallus gallus (chicken)	ACVR2B	NP_989648.1
Danio rerio (zebrafish)	acvr2b	NP_571285.1

Process

ID	Name	Evidence
GO:0001702	gastrulation with mouth forming second	IEA
GO:0001822	kidney development	IEA
GO:0006355	regulation of transcription, DNA-dependent	IDA
GO:0006468	protein phosphorylation	IEA
GO:0007165	signal transduction	IDA
GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	TAS
GO:0007368	determination of left/right symmetry	IEA
GO:0007389	pattern specification process	IEA
GO:0007498	mesoderm development	IEA
GO:0007507	heart development	IEA
GO:0009749	response to glucose stimulus	IEA
GO:0009791	post-embryonic development	IEA
GO:0009952	anterior/posterior pattern formation	IMP
GO:0030073	insulin secretion	IEA
GO:0030324	lung development	IEA
GO:0030501	positive regulation of bone mineralization	IMP
GO:0030509	BMP signaling pathway	EXP
GO:0030509	BMP signaling pathway	IDA
GO:0031016	pancreas development	IEA
GO:0032147	activation of protein kinase activity	IEA
GO:0032927	positive regulation of activin receptor signaling pathway	IDA
GO:0035265	organ growth	IEA
GO:0042475	odontogenesis of dentine-containing tooth	IEA
GO:0045669	positive regulation of osteoblast differentiation	IMP
GO:0048617	embryonic foregut morphogenesis	IEA
GO:0048705	skeletal system morphogenesis	IEA
GO:0060021	palate development	IEA

Component

Function

ID	Name	Evidence
GO:0000166	nucleotide binding	IEA
GO:0004674	protein serine/threonine kinase activity	IMP
GO:0004702	receptor signaling protein serine/threonine kinase activity	IEA
GO:0004712	protein serine/threonine/tyrosine kinase activity	IEA
GO:0004872	receptor activity	IEA
GO:0005024	transforming growth factor beta receptor activity	IEA
GO:0005515	protein binding	IPI
GO:0005524	ATP binding	IEA
GO:0016362	activin receptor activity, type II	TAS
GO:0019838	growth factor binding	IPI
GO:0046872	metal ion binding	IEA
GO:0048185	activin binding	IEA

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RefSeq Accession	Definition	Sequence	Price	Select
NM_001106	Homo sapiens activin A receptor, type IIB (ACVR2B), mRNA.	Full Length	Quote
NM_001106	Homo sapiens activin A receptor, type IIB (ACVR2B), mRNA.	ORF Sequence	$446.31