VAMP3 vesicle-associated membrane protein 3 (cellubrevin) [Homo sapiens (human)]
| Gene Symbol | VAMP3 |
| Entrez Gene ID | 9341 |
| Full Name | vesicle-associated membrane protein 3 (cellubrevin) |
| Synonyms | CEB |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
1 1p36.23 |
| Summary | Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Because of its high homology to other known VAMPs, its broad tissue distribution, and its subcellular localization, the protein encoded by this gene was shown to be the human equivalent of the rodent cellubrevin. In platelets the protein resides on a compartment that is not mobilized to the plasma membrane on calcium or thrombin stimulation. [provided by RefSeq]. |
| Disorder | MIM: 603657 |
| mRNA | NM_004781, 42544205 |
| Protein | NP_004772, 4759300 |
| Product | vesicle-associated membrane protein 3 |
| RefSeq Status | REVIEWED |
| hsa04130 | SNARE interactions in vesicular transport |
| hsa04145 | Phagosome |
Pathway Interaction Database
| arf6_traffickingpathway | Arf6 trafficking events |
| Homo sapiens (human) | VAMP3 | NP_004772.1 |
| Pan troglodytes (chimpanzee) | VAMP3 | XP_514347.2 |
| Bos taurus (cattle) | VAMP3 | NP_001039380.1 |
| Mus musculus (house mouse) | Vamp3 | NP_033524.1 |
| Rattus norvegicus (Norway rat) | Vamp3 | NP_476438.1 |
| Gallus gallus (chicken) | VAMP3 | NP_001034578.1 |
| Danio rerio (zebrafish) | vamp3 | NP_001002073.1 |
| Caenorhabditis elegans | snb-1 | NP_504688.1 |
| ID | Name | Evidence |
| GO:0001921 | positive regulation of receptor recycling | ISS |
| GO:0006461 | protein complex assembly | IEA |
| GO:0006887 | exocytosis | TAS |
| GO:0006904 | vesicle docking involved in exocytosis | TAS |
| GO:0006944 | cellular membrane fusion | TAS |
| GO:0015031 | protein transport | IEA |
| GO:0016192 | vesicle-mediated transport | ISS |
| GO:0017156 | calcium ion-dependent exocytosis | IEA |
| GO:0034446 | substrate adhesion-dependent cell spreading | ISS |
| GO:0042147 | retrograde transport, endosome to Golgi | IDA |
Component
| ID | Name | Evidence |
| GO:0005792 | microsome | IEA |
| GO:0005886 | plasma membrane | ISS |
| GO:0016021 | integral to membrane | IEA |
| GO:0019717 | synaptosome | IEA |
| GO:0030054 | cell junction | IEA |
| GO:0030136 | clathrin-coated vesicle | IDA |
| GO:0031201 | SNARE complex | IEA |
| GO:0031410 | cytoplasmic vesicle | IEA |
| GO:0045202 | synapse | IEA |
| GO:0055037 | recycling endosome | IDA |
Function
| ID | Name | Evidence |
| GO:0005515 | protein binding | IPI |
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