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MAGED1 melanoma antigen family D, 1 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu03665 NM_001005333 Homo sapiens melanoma antigen family D, 1 (MAGED1), transcript variant 1, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu18181 NM_001005332 Homo sapiens melanoma antigen family D, 1 (MAGED1), transcript variant 3, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu18181 NM_006986 Homo sapiens melanoma antigen family D, 1 (MAGED1), transcript variant 2, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu03665C NM_001005333 Homo sapiens melanoma antigen family D, 1 (MAGED1), transcript variant 1, mRNA. Customized vector In-stock 5-7 $149.00
OHu18181C NM_001005332 Homo sapiens melanoma antigen family D, 1 (MAGED1), transcript variant 3, mRNA. Customized vector In-stock 5-7 $149.00
OHu18181C NM_006986 Homo sapiens melanoma antigen family D, 1 (MAGED1), transcript variant 2, mRNA. Customized vector In-stock 5-7 $149.00

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Gene Symbol MAGED1
Entrez Gene ID 9500
Full Name melanoma antigen family D, 1
Synonyms DLXIN-1, NRAGE
General protein information
Preferred Names
melanoma-associated antigen D1
Names
melanoma-associated antigen D1
MAGE-D1 antigen
MAGE tumor antigen CCF
neurotrophin receptor-interacting MAGE homolog
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

X

Xp11.23

Summary This gene is a member of the melanoma antigen gene (MAGE) family. Most of the genes of this family encode tumor specific antigens that are not expressed in normal adult tissues except testis. Although the protein encoded by this gene shares strong homology with members of the MAGE family, it is expressed in almost all normal adult tissues. This gene has been demonstrated to be involved in the p75 neurotrophin receptor mediated programmed cell death pathway. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Disorder

MIM: 300224

mRNA Protein Product Sequence Price Select
NM_001005332, 52632378 NP_001005332, 52632379 melanoma-associated antigen D1 isoform b ORF Sequence $660.00
NM_001005333, 52632380 NP_001005333, 52632381 melanoma-associated antigen D1 isoform a ORF Sequence $660.00
NM_006986, 52632376 NP_008917, 52632377 melanoma-associated antigen D1 isoform b ORF Sequence $660.00
KEGG
hsa04722Neurotrophin signaling pathway
Pathway Interaction Database
trkrpathwayNeurotrophic factor-mediated Trk receptor signaling
p75ntrpathwayp75(NTR)-mediated signaling
Reactome
REACT_13648Regulation of Apoptosis
REACT_578Apoptosis
REACT_13720Cell death signalling via NRAGE, NRIF and NADE
REACT_13638NRAGE signals death through JNK
REACT_11061Signalling by NGF
REACT_13776p75 NTR receptor-mediated signalling
REACT_22128Role of DCC in regulating apoptosis
REACT_111102Signal Transduction
Homo sapiens (human)MAGED1NP_001005333.1
Pan troglodytes (chimpanzee)MAGED1XP_003317513.1
Macaca mulatta (Rhesus monkey)LOC696658XP_002808576.1
Canis lupus familiaris (dog)MAGED1XP_005641419.1
Bos taurus (cattle)MAGED1NP_001039590.2
Mus musculus (house mouse)Maged1NP_062765.1
Rattus norvegicus (Norway rat)Maged1NP_445861.1
Process
IDNameEvidence
GO:0006355regulation of transcription, DNA-templatedTAS
GO:0006357regulation of transcription from RNA polymerase II promoterIEA
GO:0006915apoptotic processTAS
GO:0032922circadian regulation of gene expressionISS
GO:0042981regulation of apoptotic processTAS
GO:0043065positive regulation of apoptotic processTAS
GO:0043406positive regulation of MAP kinase activityIEA
GO:0045892negative regulation of transcription, DNA-templatedIEA
GO:0045893positive regulation of transcription, DNA-templatedIEA
GO:0048011neurotrophin TRK receptor signaling pathwayTAS
GO:0050680negative regulation of epithelial cell proliferationIDA
GO:0090190positive regulation of branching involved in ureteric bud morphogenesisIEA
GO:0097190apoptotic signaling pathwayTAS
GO:2001235positive regulation of apoptotic signaling pathwayIEA
Component
IDNameEvidence
GO:0000785chromatinISS
GO:0005634nucleusISS
GO:0005737cytoplasmIEA
GO:0005886plasma membraneIEA
GO:0043234protein complexIDA
Function
IDNameEvidence
GO:0003713transcription coactivator activityIEA
GO:0005515protein bindingIPI
GeneCards MAGED1
UniProt Q9Y5V3
Vega OTTHUMG00000021540
MIM 300224
Ensembl ENSG00000179222
HGNC 6813
HPRD 02202

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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