Sequence in raw or FASTA format:
MAGED1 melanoma antigen family D, 1 [
Homo sapiens (human)]
Gene Symbol MAGED1
Entrez Gene ID
Full Name melanoma antigen family D, 1
Synonyms DLXIN-1, NRAGE
General protein information
melanoma-associated antigen D1
melanoma-associated antigen D1
MAGE tumor antigen CCF
neurotrophin receptor-interacting MAGE homolog
Gene Type protein-coding
Homo sapiens (human)
Chromosome:X Map Location:Xp11.23
Summary This gene is a member of the melanoma antigen gene (MAGE) family. Most of the genes of this family encode tumor specific antigens that are not expressed in normal adult tissues except testis. Although the protein encoded by this gene shares strong homology with members of the MAGE family, it is expressed in almost all normal adult tissues. This gene has been demonstrated to be involved in the p75 neurotrophin receptor mediated programmed cell death pathway. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Pathway Interaction Database
ID Name Evidence
GO:0006355 regulation of transcription, DNA-templated TAS
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA
GO:0006915 apoptotic process TAS
GO:0032922 circadian regulation of gene expression ISS
GO:0042981 regulation of apoptotic process TAS
GO:0043065 positive regulation of apoptotic process TAS
GO:0043406 positive regulation of MAP kinase activity IEA
GO:0045892 negative regulation of transcription, DNA-templated IEA
GO:0045893 positive regulation of transcription, DNA-templated IEA
GO:0048011 neurotrophin TRK receptor signaling pathway TAS
GO:0050680 negative regulation of epithelial cell proliferation IDA
GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis IEA
GO:0097190 apoptotic signaling pathway TAS
GO:2001235 positive regulation of apoptotic signaling pathway IEA
Related articles in PubMed Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. Povlsen LK, et al. Nat Cell Biol, 2012 Oct. PMID 23000965. Prognostic relevance of melanoma antigen D1 expression in colorectal carcinoma. Zeng ZL, et al. J Transl Med, 2012 Aug 31. PMID 22935435. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. Aichem A, et al. J Cell Sci, 2012 Oct 1. PMID 22797925. Ubiquitin-specific peptidase 9, X-linked (USP9X) modulates activity of mammalian target of rapamycin (mTOR). Agrawal P, et al. J Biol Chem, 2012 Jun 15. PMID 22544753. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. Udeshi ND, et al. Mol Cell Proteomics, 2012 May. PMID 22505724. See all (55) citations in PubMed See citations in PubMed for homologs of this gene provided by HomoloGene
GeneRIFs: Gene References Into Functions
What's a GeneRIF?
Univariate and multivariate analyses indicated that MAGED1 expression was an independent prognostic factor in colorectal carcinoma
Title: Prognostic relevance of melanoma antigen D1 expression in colorectal carcinoma.
NRAGE may participate in the formation of radioresistance of TE13R120 cells by changing its subcellular localization, but its relationship with cell apoptosis has not been confirmed.
Title: Relationship between NRAGE and the radioresistance of esophageal carcinoma cell line TE13R120.
we establish the roles for Dlxin-1, one as an anti-tumorigenic and anti-invasive protein in high-grade gliomas and the other as an inducer of differentiation of glioma stem cells.
Title: Dlxin-1, a member of MAGE family, inhibits cell proliferation, invasion and tumorigenicity of glioma stem cells.
Data report that NRAGE, via the same XIAP-Tak1-Tab1 complex, is required for the phosphorylation of IKK -alpha/beta and subsequent transcriptional activation of the p65 subunit of NF-kappaB.
Title: A role for NRAGE in NF-kappaB activation through the non-canonical BMP pathway.
Observational study of gene-disease association. (HuGE Navigator)
Title: New genetic associations detected in a host response study to hepatitis B vaccine.
Enhanced expression of MAGE-D1 by gene transfer could reverse the malignant phenotypes of breast cancer cells.
Title: MAGE-D1 inhibits proliferation, migration and invasion of human breast cancer cells.
Data show that hNRAGE gene can inhibit the growth of 293 cells.
Title: [Construction of recombinant adenovirus vector of hNRAGE gene and its effect on cell cycle of 293 cells].
These findings provide new insight into the ability of MAGE-D1 to suppress the motility and adhesion response of tumor cells by interfering with actin cytoskeleton reorganization and hypoxia inducible factor 1-dependent gene expression.
Title: Melanoma-associated antigen family protein-D1 regulation of tumor cell migration, adhesion to endothelium, and actin structures reorganization in response to hypoxic stress.
MAGE-D1 might be a novel inhibitor of angiogenesis in vitro and in vivo.
Title: Inhibition of adenovirus-mediated human MAGE-D1 on angiogenesis in vitro and in vivo.
A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1.
Title: A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1.
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