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Sequence in raw or FASTA format:

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ADAMTSL2 ADAMTS-like 2 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001145320 Homo sapiens ADAMTS-like 2 (ADAMTSL2), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $899.00 20
NM_014694 Homo sapiens ADAMTS-like 2 (ADAMTSL2), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $899.00 20
XM_005272237 PREDICTED: Homo sapiens ADAMTS-like 2 (ADAMTSL2), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
XM_005272238 PREDICTED: Homo sapiens ADAMTS-like 2 (ADAMTSL2), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $899.00 20
XM_005272239 PREDICTED: Homo sapiens ADAMTS-like 2 (ADAMTSL2), transcript variant X3, mRNA. GenEZ ORF Cloning On-demand $899.00 20
XM_006717336 PREDICTED: Homo sapiens ADAMTS-like 2 (ADAMTSL2), transcript variant X4, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
XM_006717337 PREDICTED: Homo sapiens ADAMTS-like 2 (ADAMTSL2), transcript variant X5, mRNA. GenEZ ORF Cloning On-demand $899.00 20

*Business Day

Related Services

Gene Symbol ADAMTSL2
Entrez Gene ID 9719
Full Name ADAMTS-like 2
Synonyms GPHYSD1
General protein information
Preferred Names
ADAMTS-like protein 2
Names
ADAMTS-like protein 2
ADAMTSL-2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

9

9q34.2

Summary This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) and ADAMTS-like protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene lacks the protease domain, and is therefore of a member of the the ADAMTS-like protein subfamily. It is a secreted glycoprotein that binds the cell surface and extracellular matrix; it also interacts with latent transforming growth factor beta binding protein 1. Mutations in this gene have been associated with geleophysic dysplasia. [provided by RefSeq, Feb 2009].
Disorder

MIM: 612277

Geleophysic dysplasia, 231050 (3)

mRNA Protein Product Sequence Price Select
NM_001145320, 223718259 NP_001138792, 223718260 ADAMTS-like protein 2 precursor ORF Sequence $750.00
NM_014694, 223718256 NP_055509, 41281450 ADAMTS-like protein 2 precursor ORF Sequence $750.00
XM_005272237, 530427262 XP_005272294, 530427263 ADAMTS-like protein 2 isoform X1 ORF Sequence $1500.00
XM_005272238, 530427264 XP_005272295, 530427265 ADAMTS-like protein 2 isoform X2 ORF Sequence $750.00
XM_005272239, 530427266 XP_005272296, 530427267 ADAMTS-like protein 2 isoform X3 ORF Sequence $750.00
XM_006717336, 578818017 XP_006717399, 578818018 ADAMTS-like protein 2 isoform X4 ORF Sequence $1500.00
XM_006717337, 578818019 XP_006717400, 578818020 ADAMTS-like protein 2 isoform X5 ORF Sequence $750.00
Reactome
REACT_17015Metabolism of proteins
REACT_22161Post-translational protein modification
REACT_200727O-linked glycosylation
REACT_200626O-glycosylation of TSR domain-containing proteins
Homo sapiens (human)ADAMTSL2NP_001138792.1
Pan troglodytes (chimpanzee)ADAMTSL2XP_001169765.2
Macaca mulatta (Rhesus monkey)LOC713492XP_002808139.1
Canis lupus familiaris (dog)ADAMTSL2XP_003639356.1
Bos taurus (cattle)ADAMTSL2NP_001192863.1
Mus musculus (house mouse)Adamtsl2NP_084257.1
Rattus norvegicus (Norway rat)Adamtsl2XP_231125.3
Gallus gallus (chicken)ADAMTSL2XP_004946003.1
Danio rerio (zebrafish)adamtsl2XP_003198768.2
Xenopus (Silurana) tropicalis (western clawed frog)adamtsl2XP_004919863.1
Process
IDNameEvidence
GO:0006508proteolysisIEA
GO:0030512negative regulation of transforming growth factor beta receptor signaling pathwayIMP
Component
IDNameEvidence
GO:0005578proteinaceous extracellular matrixIEA
Function
IDNameEvidence
GO:0004222metalloendopeptidase activityIEA
GO:0005515protein bindingIPI
GO:0008270zinc ion bindingIEA
GeneCards ADAMTSL2
UniProt B1B0D4, Q86TH1
Vega OTTHUMG00000131706
MIM 612277
Ensembl ENSG00000197859
HGNC 14631
HPRD 11096

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the ADAMTSL2 gene?

The ADAMTSL2 gene provides instructions for making a protein whose function is unknown. The ADAMTSL2 protein is active in many different tissues. It is found in the extracellular matrix, which is the intricate lattice of proteins and other molecules that forms in the spaces between cells.

Studies suggest that the ADAMTSL2 protein interacts with a protein called latent transforming growth factor beta binding protein 1 (LTBP1). The LTBP1 protein is involved in the storage of transforming growth factor beta (TGF-β), a critical growth factor that helps control the growth and division (proliferation) of cells, the process by which cells mature to carry out specific functions (differentiation), cell movement (motility), and the self-destruction of cells (apoptosis). Through its interaction with the LTBP1 protein, researchers suspect that the ADAMTSL2 protein may help regulate the availability of TGF-β.

The interaction between the ADAMTSL2 protein and the LTBP1 protein suggests that ADAMTSL2 may also play a role in the microfibrillar network. This organized clustering of thread-like filaments (called microfibrils) in the extracellular matrix provides strength and flexibility to tissues throughout the body.

Interactant

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