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MAML1 mastermind-like 1 (Drosophila) [Homo sapiens (human)]

Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu06660D NM_014757 Homo sapiens mastermind-like 1 (Drosophila) (MAML1), mRNA. pcDNA3.1-C-(k)DYK On-demand TBD Starting from $99
OHu06660C NM_014757 Homo sapiens mastermind-like 1 (Drosophila) (MAML1), mRNA. Customized vector On-demand TBD Starting from $99

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Gene Symbol MAML1
Entrez Gene ID 9794
Full Name mastermind-like 1 (Drosophila)
Synonyms Mam-1, Mam1
General protein information
Preferred Names
mastermind-like protein 1
mastermind-like protein 1
mastermind homolog
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway. [provided by RefSeq, Jul 2008].

MIM: 605424

mRNA Protein Product Sequence Price Select
NM_014757, 208022630 NP_055572, 7661990 mastermind-like protein 1 ORF Sequence $1500.00
hsa04330Notch signaling pathway
WP61Delta-Notch Signaling Pathway
WP268Notch Signaling Pathway
Pathway Interaction Database
notch_pathwayNotch signaling pathway
hes_heypathwayNotch-mediated HES/HEY network
REACT_12627Generic Transcription Pathway
REACT_71Gene Expression
REACT_14835Notch-HLH transcription pathway
REACT_299Signaling by NOTCH
REACT_111102Signal Transduction
REACT_118744Pre-NOTCH Expression and Processing
REACT_118859Signaling by NOTCH1
REACT_118568Pre-NOTCH Transcription and Translation
REACT_118721Signaling by NOTCH2
REACT_118780NOTCH1 Intracellular Domain Regulates Transcription
REACT_163910NOTCH2 intracellular domain regulates transcription
REACT_160248Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
REACT_160254Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
REACT_160099FBXW7 Mutants and NOTCH1 in Cancer
REACT_160243Constitutive Signaling by NOTCH1 PEST Domain Mutants
REACT_160214Signaling by NOTCH1 in Cancer
REACT_160082Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
REACT_160133Signaling by NOTCH1 HD Domain Mutants in Cancer
REACT_160301Signaling by NOTCH1 PEST Domain Mutants in Cancer
Homo sapiens (human)MAML1NP_055572.1
Pan troglodytes (chimpanzee)MAML1XP_527150.3
Macaca mulatta (Rhesus monkey)MAML1XP_001105097.2
Canis lupus familiaris (dog)MAML1XP_005626406.1
Bos taurus (cattle)MAML1XP_005208449.1
Mus musculus (house mouse)Maml1NP_780543.2
Rattus norvegicus (Norway rat)Maml1NP_001100467.1
Gallus gallus (chicken)MAML1XP_414607.4
Danio rerio (zebrafish)LOC567335XP_005157273.1
Xenopus (Silurana) tropicalis (western clawed frog)maml1XP_002941844.2
GO:0003162atrioventricular node developmentISS
GO:0006367transcription initiation from RNA polymerase II promoterTAS
GO:0006468protein phosphorylationIDA
GO:0007219Notch signaling pathwayIDA
GO:0007219Notch signaling pathwayTAS
GO:0010467gene expressionTAS
GO:0010831positive regulation of myotube differentiationIGI
GO:0045445myoblast differentiationIEA
GO:0045944positive regulation of transcription from RNA polymerase II promoterIDA
GO:0060928atrioventricular node cell developmentISS
GO:0002193MAML1-RBP-Jkappa- ICN1 complexIDA
GO:0016607nuclear speckIEA
GO:0043231intracellular membrane-bounded organelleIDA
GO:0003713transcription coactivator activityIDA
GO:0005515protein bindingIPI
GO:0019901protein kinase bindingIPI
GO:0042605peptide antigen bindingIPI
GeneCards MAML1
PDB 3NBN, 2F8X, 3V79
UniProt Q92585
Vega OTTHUMG00000163237
MIM 605424
Ensembl ENSG00000161021
HGNC 13632
HPRD 05665

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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