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MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_012301 Homo sapiens membrane associated guanylate kinase, WW and PDZ domain containing 2 (MAGI2), mRNA. GenEZ ORF Cloning On-demand TBD TBD
XM_005250725 PREDICTED: Homo sapiens membrane associated guanylate kinase, WW and PDZ domain containing 2 (MAGI2), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand TBD TBD

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Gene Symbol MAGI2
Entrez Gene ID 9863
Full Name membrane associated guanylate kinase, WW and PDZ domain containing 2
Synonyms ACVRIP1, AIP-1, AIP1, ARIP1, MAGI-2, SSCAM
General protein information
Preferred Names
membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
Names
membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
atrophin-1-interacting protein 1
atrophin-1-interacting protein A
activin receptor interacting protein 1
membrane-associated guanylate kinase inverted 2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

7

7q21

Summary The protein encoded by this gene interacts with atrophin-1. Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. This encoded protein is characterized by two WW domains, a guanylate kinase-like domain, and multiple PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue (MAGUK) family. [provided by RefSeq, Jul 2008].
Disorder

MIM: 606382

mRNA Protein Product Sequence Price Select
NM_012301, 66346709 NP_036433, 27436957 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 ORF Sequence $1500.00
XM_005250725, 578814802 XP_005250782, 530386693 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1 ORF Sequence $1500.00
KEGG
hsa04530Tight junction
hsa04668TNF signaling pathway
hsa04015Rap1 signaling pathway
Reactome
REACT_23832Nephrin interactions
REACT_111155Cell-Cell communication
Homo sapiens (human)MAGI2NP_036433.2
Pan troglodytes (chimpanzee)MAGI2XP_519172.3
Canis lupus familiaris (dog)MAGI2XP_005631075.1
Bos taurus (cattle)MAGI2XP_002686815.1
Mus musculus (house mouse)Magi2NP_001164217.1
Rattus norvegicus (Norway rat)Magi2NP_446073.1
Gallus gallus (chicken)MAGI2NP_001186469.1
Danio rerio (zebrafish)magi2NP_001116083.1
Caenorhabditis elegansmagi-1NP_001255577.1
Process
IDNameEvidence
GO:0002092positive regulation of receptor internalizationIDA
GO:0003402planar cell polarity pathway involved in axis elongationNAS
GO:0008285negative regulation of cell proliferationISS
GO:0010976positive regulation of neuron projection developmentISS
GO:0016482cytoplasmic transportISS
GO:0030336negative regulation of cell migrationISS
GO:0032516positive regulation of phosphoprotein phosphatase activityIDA
GO:0032926negative regulation of activin receptor signaling pathwayISS
GO:0038180nerve growth factor signaling pathwayISS
GO:0043113receptor clusteringISS
GO:0051291protein heterooligomerizationISS
GO:0051898negative regulation of protein kinase B signalingIDA
GO:0060395SMAD protein signal transductionISS
GO:0071850mitotic cell cycle arrestISS
GO:0072015glomerular visceral epithelial cell developmentISS
GO:1990090cellular response to nerve growth factor stimulusISS
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005737cytoplasmIDA
GO:0005770late endosomeISS
GO:0005886plasma membraneIDA
GO:0005923tight junctionIDA
GO:0014069postsynaptic densityISS
GO:0030425dendriteISS
GO:0036057slit diaphragmISS
GO:0043234protein complexISS
GO:0045202synapseISS
GO:0048471perinuclear region of cytoplasmISS
Function
IDNameEvidence
GO:0004871signal transducer activityIEA
GO:0005515protein bindingIPI
GO:0019902phosphatase bindingIPI
GO:0030159receptor signaling complex scaffold activityIDA
GO:0031697beta-1 adrenergic receptor bindingIPI
GO:0046332SMAD bindingISS
GO:0070699type II activin receptor bindingISS
GeneCards MAGI2
UniProt Q86UL8
Vega OTTHUMG00000130697
MIM 606382
Ensembl ENSG00000187391
HGNC 18957
HPRD 16212

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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