• THAT   AND
  • THAT   AND


Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


KCNE2 potassium voltage-gated channel, Isk-related family, member 2 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_172201 Homo sapiens potassium voltage-gated channel, Isk-related family, member 2 (KCNE2), mRNA. GenEZ ORF Cloning In-stock $248.00 $199.00 10

*Business Day

Related Services

Gene Symbol KCNE2
Entrez Gene ID 9992
Full Name potassium voltage-gated channel, Isk-related family, member 2
Synonyms ATFB4, LQT5, LQT6, MIRP1
General protein information
Preferred Names
potassium voltage-gated channel subfamily E member 2
Names
potassium voltage-gated channel subfamily E member 2
minK-related peptide 1
minK-related peptide-1
potassium channel subunit, MiRP1
potassium channel subunit beta MiRP1
voltage-gated K+ channel subunit MIRP1
minimum potassium ion channel-related peptide 1
cardiac voltage-gated potassium channel accessory subunit 2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

21

21q22.12

Summary Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a small integral membrane subunit that assembles with the KCNH2 gene product, a pore-forming protein, to alter its function. This gene is expressed in heart and muscle and the gene mutations are associated with cardiac arrhythmia. [provided by RefSeq, Jul 2008].
Disorder

MIM: 603796

Long QT syndrome-6, 613693 (3); Atrial fibrillation, familial, 4,

mRNA Protein Product Sequence Price Select
NM_172201, 27436977 NP_751951, 27436978 potassium voltage-gated channel subfamily E member 2 ORF Sequence $99.00
KEGG
hsa04971Gastric acid secretion
Homo sapiens (human)KCNE2NP_751951.1
Pan troglodytes (chimpanzee)KCNE2XP_001167267.1
Macaca mulatta (Rhesus monkey)KCNE2XP_001089749.1
Canis lupus familiaris (dog)KCNE2NP_001181892.1
Bos taurus (cattle)KCNE2NP_001070552.1
Mus musculus (house mouse)Kcne2NP_598871.1
Rattus norvegicus (Norway rat)Kcne2NP_598287.1
Gallus gallus (chicken)KCNE2XP_004934590.1
Xenopus (Silurana) tropicalis (western clawed frog)LOC100490092XP_002937553.1
Process
IDNameEvidence
GO:0007568agingIEA
GO:0010107potassium ion importIMP
GO:0034613cellular protein localizationIEA
GO:0035690cellular response to drugIDA
GO:0043586tongue developmentIEA
GO:0060306regulation of membrane repolarizationIDA
GO:0060307regulation of ventricular cardiac muscle cell membrane repolarizationIMP
GO:0071435potassium ion exportIDA
GO:0071805potassium ion transmembrane transportIDA
GO:0086002cardiac muscle cell action potential involved in contractionIMP
GO:0086005ventricular cardiac muscle cell action potentialIMP
GO:0086009membrane repolarizationIDA
GO:0086011membrane repolarization during action potentialIMP
GO:0086091regulation of heart rate by cardiac conductionIMP
GO:1901379regulation of potassium ion transmembrane transportIDA
GO:1901800positive regulation of proteasomal protein catabolic processIDA
GO:1901979regulation of inward rectifier potassium channel activityIDA
GO:1902159regulation of cyclic nucleotide-gated ion channel activityIEA
GO:1902259regulation of delayed rectifier potassium channel activityIDA
Component
IDNameEvidence
GO:0005764lysosomeIDA
GO:0005886plasma membraneIDA
GO:0008076voltage-gated potassium channel complexIDA
GO:0009986cell surfaceIDA
Function
IDNameEvidence
GO:0005242inward rectifier potassium channel activityIDA
GO:0005251delayed rectifier potassium channel activityIDA
GO:0015459potassium channel regulator activityIDA
GO:0042803protein homodimerization activityIEA
GO:0044325ion channel bindingIDA
GO:1902282voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarizationIMP
GeneCards KCNE2
PDB 2M0Q
UniProt Q9Y6J6
MIM 603796
HGNC 6242
HPRD 04813

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the KCNE2 gene?

The KCNE2 gene provides instructions for making a protein that regulates the activity of potassium channels. These channels, which transport positively charged atoms (ions) of potassium into and out of cells, play a key role in a cell's ability to generate and transmit electrical signals.

The specific function of a potassium channel depends on its protein components and its location in the body. The KCNE2 protein regulates several ion channels, including a channel made up of proteins produced by the KCNH2 gene. Channels made with the KCNH2 protein are present in heart (cardiac) muscle, where they transport potassium ions out of cells. This form of ion transport is involved in recharging the cardiac muscle after each heartbeat to maintain a regular rhythm.

The proteins produced from the KCNH2 and KCNE2 genes interact to form a functional potassium channel. Four alpha subunits, each produced from the KCNH2 gene, form the structure of each channel. One beta subunit, produced from the KCNE2 gene, binds to the channel and regulates its activity.

Interactant

Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.