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NR2E3 nuclear receptor subfamily 2, group E, member 3 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_014249 Homo sapiens nuclear receptor subfamily 2, group E, member 3 (NR2E3), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand TBD TBD
NM_016346 Homo sapiens nuclear receptor subfamily 2, group E, member 3 (NR2E3), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand TBD TBD

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Related Services

Gene Symbol NR2E3
Entrez Gene ID 10002
Full Name nuclear receptor subfamily 2, group E, member 3
Synonyms ESCS, PNR, RNR, RP37, rd7
General protein information
Preferred Names
photoreceptor-specific nuclear receptor
Names
photoreceptor-specific nuclear receptor
retina-specific nuclear receptor
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

15

15q23

Summary This protein is part of a large family of nuclear receptor transcription factors involved in signaling pathways. Nuclear receptors have been shown to regulate pathways involved in embryonic development, as well as in maintenance of proper cell function in adults. Members of this family are characterized by discrete domains that function in DNA and ligand binding. This gene encodes a retinal nuclear receptor that is a ligand-dependent transcription factor. Defects in this gene are a cause of enhanced S cone syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
Disorder

MIM: 604485

Enhanced S-cone syndrome, 268100 (3); Retinitis pigmentosa-37,

mRNA Protein Product Sequence Price Select
NM_014249, 527122106 NP_055064, 7657395 photoreceptor-specific nuclear receptor isoform b ORF Sequence $400.00
NM_016346, 527122105 NP_057430, 7706515 photoreceptor-specific nuclear receptor isoform a ORF Sequence $400.00
Reactome
REACT_12627Generic Transcription Pathway
REACT_71Gene Expression
REACT_15525Nuclear Receptor transcription pathway
Homo sapiens (human)NR2E3NP_055064.1
Pan troglodytes (chimpanzee)NR2E3XP_001175025.1
Macaca mulatta (Rhesus monkey)NR2E3XP_001089693.1
Bos taurus (cattle)NR2E3NP_001161372.1
Mus musculus (house mouse)Nr2e3NP_038736.1
Rattus norvegicus (Norway rat)LOC100365683XP_003750575.2
Gallus gallus (chicken)NR2E3NP_989925.1
Danio rerio (zebrafish)nr2e3NP_001007369.1
Drosophila melanogaster (fruit fly)Hr51NP_611032.2
Xenopus (Silurana) tropicalis (western clawed frog)nr2e3NP_001090633.1
Process
IDNameEvidence
GO:0006355regulation of transcription, DNA-templatedIEA
GO:0006366transcription from RNA polymerase II promoterTAS
GO:0006367transcription initiation from RNA polymerase II promoterTAS
GO:0007165signal transductionTAS
GO:0007601visual perceptionIEA
GO:0007602phototransductionTAS
GO:0010467gene expressionTAS
GO:0030522intracellular receptor signaling pathwayTAS
GO:0043401steroid hormone mediated signaling pathwayIEA
Component
IDNameEvidence
GO:0005634nucleusTAS
GO:0005654nucleoplasmTAS
Function
IDNameEvidence
GO:0003707steroid hormone receptor activityIEA
GO:0004879ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityTAS
GO:0005515protein bindingIPI
GO:0008270zinc ion bindingIEA
GO:0043565sequence-specific DNA bindingIEA
GeneCards NR2E3
PDB 4LOG
UniProt F1D8Q9, Q9Y5X4
MIM 604485
HGNC 7974
HPRD 05132

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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