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HCN4 hyperpolarization activated cyclic nucleotide-gated potassium channel 4 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_005477 Homo sapiens hyperpolarization activated cyclic nucleotide-gated potassium channel 4 (HCN4), mRNA. GenEZ ORF Cloning On-demand TBD TBD

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Gene Symbol HCN4
Entrez Gene ID 10021
Full Name hyperpolarization activated cyclic nucleotide-gated potassium channel 4
Synonyms SSS2
General protein information
Preferred Names
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
hyperpolarization activated cyclic nucleotide-gated cation channel 4
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene encodes a member of the hyperpolarization-activated cyclic nucleotide-gated potassium channels. The encoded protein shows slow kinetics of activation and inactivation, and is necessary for the cardiac pacemaking process. This channel may also mediate responses to sour stimuli. Mutations in this gene have been linked to sick sinus syndrome 2, also known as atrial fibrillation with bradyarrhythmia or familial sinus bradycardia. Two pseudogenes have been identified on chromosome 15. [provided by RefSeq, Oct 2008].

MIM: 605206

Sick sinus syndrome 2, 163800 (3); Brugada syndrome 8, 613123 (3)

mRNA Protein Product Sequence Price Select
NM_005477, 210147528 NP_005468, 4885407 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 ORF Sequence $1500.00
REACT_13685Neuronal System
REACT_75908Potassium Channels
REACT_75862HCN channels
Homo sapiens (human)HCN4NP_005468.1
Pan troglodytes (chimpanzee)HCN4XP_003952750.1
Macaca mulatta (Rhesus monkey)HCN4XP_002804905.1
Bos taurus (cattle)HCN4XP_002690539.1
Mus musculus (house mouse)Hcn4NP_001074661.1
Rattus norvegicus (Norway rat)Hcn4NP_067690.1
Gallus gallus (chicken)HCN4XP_425050.3
Danio rerio (zebrafish)hcn4XP_686078.4
Danio rerio (zebrafish)hcn4lXP_684730.5
Xenopus (Silurana) tropicalis (western clawed frog)hcn4XP_004916024.1
GO:0001701in utero embryonic developmentIEA
GO:0002027regulation of heart rateIMP
GO:0006812cation transportTAS
GO:0006936muscle contractionTAS
GO:0007268synaptic transmissionTAS
GO:0008015blood circulationNAS
GO:0034765regulation of ion transmembrane transportIEA
GO:0035725sodium ion transmembrane transportIMP
GO:0042391regulation of membrane potentialIBA
GO:0042391regulation of membrane potentialIMP
GO:0071320cellular response to cAMPIDA
GO:0071321cellular response to cGMPIDA
GO:0071805potassium ion transmembrane transportIBA
GO:0071805potassium ion transmembrane transportIDA
GO:0071805potassium ion transmembrane transportIMP
GO:0005886plasma membraneIDA
GO:0005886plasma membraneTAS
GO:0005887integral component of plasma membraneIBA
GO:0031226intrinsic component of plasma membraneIDA
GO:0043195terminal boutonIEA
GO:0005222intracellular cAMP activated cation channel activityIDA
GO:0005248voltage-gated sodium channel activityIMP
GO:0005249voltage-gated potassium channel activityIBA
GO:0005249voltage-gated potassium channel activityIDA
GO:0005249voltage-gated potassium channel activityIMP
GO:0005261cation channel activityTAS
GO:0030552cAMP bindingIEA
GO:0042802identical protein bindingIPI
GeneCards HCN4
PDB 4HBN, 3U11, 3OTF, 4NVP, 4KL1
UniProt Q9Y3Q4
Vega OTTHUMG00000137563
MIM 605206
Ensembl ENSG00000138622
HGNC 16882
HPRD 09240

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the HCN4 gene?

The HCN4 gene provides instructions for making a channel that transports positively charged atoms (ions) into heart muscle cells. This channel is located primarily in the sino-atrial (SA) node, which is an area of specialized cells in the heart that functions as a natural pacemaker. The HCN4 channel allows potassium and sodium ions to flow into cells of the SA node. This ion flow is often called the "pacemaker current" because it generates electrical impulses that start each heartbeat and is involved in maintaining a regular heart rhythm.


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