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HCN4 hyperpolarization activated cyclic nucleotide-gated potassium channel 4 [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_005477 Homo sapiens hyperpolarization activated cyclic nucleotide-gated potassium channel 4 (HCN4), mRNA. ORF Sequence $1264.20
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Gene Symbol HCN4
Entrez Gene ID 10021
Full Name hyperpolarization activated cyclic nucleotide-gated potassium channel 4
Synonyms SSS2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

15

15q24.1

Summary This gene encodes a member of the hyperpolarization-activated cyclic nucleotide-gated potassium channels. The encoded protein shows slow kinetics of activation and inactivation, and is necessary for the cardiac pacemaking process. This channel may also mediate responses to sour stimuli. Mutations in this gene have been linked to sick sinus syndrome 2, also known as atrial fibrillation with bradyarrhythmia or familial sinus bradycardia. Two pseudogenes have been identified on chromosome 15. [provided by RefSeq, Oct 2008].
Disorder

MIM: 605206

Sick sinus syndrome 2, 163800 (3); Brugada syndrome 8, 613123 (3)

mRNA Protein Product Sequence Price Select
NM_005477, 210147528 NP_005468, 4885407 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Full Length $3260.25
ORF Sequence $1264.20
Reactome
REACT_75862HCN channels
REACT_13685Neuronal System
REACT_75908Potassium Channels
Homo sapiens (human)HCN4NP_005468.1
Bos taurus (cattle)HCN4XP_002690539.1
Mus musculus (house mouse)Hcn4NP_001074661.1
Rattus norvegicus (Norway rat)Hcn4NP_067690.1
Gallus gallus (chicken)HCN4XP_425050.3
Arabidopsis thaliana (thale cress)KAT2NP_193563.3
Arabidopsis thaliana (thale cress)KAT1NP_199436.1
GeneCards HCN4
PDB 4HBN, 3U11, 3OTF
UniProt Q9Y3Q4
MIM 605206
Ensembl ENSG00000138622
HGNC 16882
HPRD 09240

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Names
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
hyperpolarization activated cyclic nucleotide-gated cation channel 4

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