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PIGK phosphatidylinositol glycan anchor biosynthesis, class K [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu04946 NM_005482 Homo sapiens phosphatidylinositol glycan anchor biosynthesis, class K (PIGK), mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu04946C NM_005482 Homo sapiens phosphatidylinositol glycan anchor biosynthesis, class K (PIGK), mRNA. Customized vector In-stock 5-7 $149.00

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Gene Symbol PIGK
Entrez Gene ID 10026
Full Name phosphatidylinositol glycan anchor biosynthesis, class K
Synonyms GPI8
General protein information
Preferred Names
GPI-anchor transamidase
Names
GPI-anchor transamidase
PIG-K
GPI8 homolog
GPI transamidase subunit
phosphatidylinositol glycan, class K
phosphatidylinositol-glycan biosynthesis class K protein
NP_005473.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1p31.1

Summary This gene encodes a member of the cysteine protease family C13 that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is a member of the multisubunit enzyme, GPI transamidase and is thought to be its enzymatic component. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins. [provided by RefSeq, Jul 2008].
Disorder

MIM: 605087

mRNA Protein Product Sequence Price Select
NM_005482, 110224470 NP_005473, 23199983 GPI-anchor transamidase precursor ORF Sequence $269.00
KEGG
hsa00563Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
Reactome
REACT_1853Post-translational modification: synthesis of GPI-anchored proteins
REACT_17015Metabolism of proteins
REACT_1830Attachment of GPI anchor to uPAR
REACT_22161Post-translational protein modification
Homo sapiens (human)PIGKNP_005473.1
Pan troglodytes (chimpanzee)PIGKXP_001168438.1
Macaca mulatta (Rhesus monkey)PIGKXP_001102474.1
Canis lupus familiaris (dog)PIGKXP_853775.1
Bos taurus (cattle)PIGKNP_001071348.1
Mus musculus (house mouse)PigkNP_079938.1
Rattus norvegicus (Norway rat)PigkNP_001011953.1
Gallus gallus (chicken)PIGKNP_001026449.1
Danio rerio (zebrafish)pigkNP_001002149.1
Drosophila melanogaster (fruit fly)CG4406NP_569968.2
Caenorhabditis eleganshpo-4NP_502076.2
Arabidopsis thaliana (thale cress)AT1G08750NP_849616.1
Xenopus (Silurana) tropicalis (western clawed frog)pigkNP_001072709.1
Process
IDNameEvidence
GO:0006457protein foldingTAS
GO:0006501C-terminal protein lipidationTAS
GO:0006508proteolysisIEA
GO:0016255attachment of GPI anchor to proteinTAS
GO:0043687post-translational protein modificationTAS
GO:0044267cellular protein metabolic processTAS
Component
IDNameEvidence
GO:0005789endoplasmic reticulum membraneTAS
GO:0016020membraneIDA
GO:0030176integral component of endoplasmic reticulum membraneNAS
GO:0042765GPI-anchor transamidase complexIMP
Function
IDNameEvidence
GO:0003756protein disulfide isomerase activityTAS
GO:0003923GPI-anchor transamidase activityIMP
GO:0003923GPI-anchor transamidase activityTAS
GO:0004197cysteine-type endopeptidase activityIEA
GO:0005515protein bindingIPI
GO:0034235GPI anchor bindingTAS
GeneCards PIGK
UniProt Q92643
Vega OTTHUMG00000009686
MIM 605087
Ensembl ENSG00000142892
HGNC 8965
HPRD 05474

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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