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ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_005691 Homo sapiens ATP-binding cassette, sub-family C (CFTR/MRP), member 9 (ABCC9), transcript variant SUR2A, mRNA. GenEZ ORF Cloning On-demand $2699.00 30
NM_020297 Homo sapiens ATP-binding cassette, sub-family C (CFTR/MRP), member 9 (ABCC9), transcript variant SUR2B, mRNA. GenEZ ORF Cloning On-demand $2699.00 30
XM_005253284 PREDICTED: Homo sapiens ATP-binding cassette, sub-family C (CFTR/MRP), member 9 (ABCC9), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $2699.00 30
XM_005253286 PREDICTED: Homo sapiens ATP-binding cassette, sub-family C (CFTR/MRP), member 9 (ABCC9), transcript variant X3, mRNA. GenEZ ORF Cloning On-demand $2699.00 30
XM_005253287 PREDICTED: Homo sapiens ATP-binding cassette, sub-family C (CFTR/MRP), member 9 (ABCC9), transcript variant X4, mRNA. GenEZ ORF Cloning On-demand $2699.00 30
XM_005253288 PREDICTED: Homo sapiens ATP-binding cassette, sub-family C (CFTR/MRP), member 9 (ABCC9), transcript variant X5, mRNA. GenEZ ORF Cloning On-demand $2699.00 30
XM_005253289 PREDICTED: Homo sapiens ATP-binding cassette, sub-family C (CFTR/MRP), member 9 (ABCC9), transcript variant X6, mRNA. GenEZ ORF Cloning On-demand $2699.00 30
XM_005253290 PREDICTED: Homo sapiens ATP-binding cassette, sub-family C (CFTR/MRP), member 9 (ABCC9), transcript variant X7, mRNA. GenEZ ORF Cloning On-demand $2699.00 30
XM_005253291 PREDICTED: Homo sapiens ATP-binding cassette, sub-family C (CFTR/MRP), member 9 (ABCC9), transcript variant X8, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
XM_006719025 PREDICTED: Homo sapiens ATP-binding cassette, sub-family C (CFTR/MRP), member 9 (ABCC9), transcript variant X9, mRNA. GenEZ ORF Cloning On-demand $2699.00 30

*Business Day

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Gene Symbol ABCC9
Entrez Gene ID 10060
Full Name ATP-binding cassette, sub-family C (CFTR/MRP), member 9
Synonyms ABC37, ATFB12, CANTU, CMD1O, SUR2
General protein information
Preferred Names
ATP-binding cassette sub-family C member 9
Names
ATP-binding cassette sub-family C member 9
sulfonylurea receptor 2
ATP-binding cassette transporter sub-family C member 9
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

12

12p12.1

Summary The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is thought to form ATP-sensitive potassium channels in cardiac, skeletal, and vascular and non-vascular smooth muscle. Protein structure suggests a role as the drug-binding channel-modulating subunit of the extra-pancreatic ATP-sensitive potassium channels. Mutations in this gene are associated with cardiomyopathy dilated type 1O. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2011].
Disorder

MIM: 601439

Cardiomyopathy, dilated, 1O, 608569 (3)

mRNA Protein Product Sequence Price Select
NM_005691, 574957131 NP_005682, 110832835 ATP-binding cassette sub-family C member 9 isoform SUR2A ORF Sequence $2500.00
NM_020297, 574957036 NP_064693, 110832837 ATP-binding cassette sub-family C member 9 isoform SUR2B ORF Sequence $2500.00
XM_005253284, 578822731 XP_005253341, 530398962 ATP-binding cassette sub-family C member 9 isoform X1 ORF Sequence $2500.00
XM_005253286, 578822732 XP_005253343, 530398966 ATP-binding cassette sub-family C member 9 isoform X3 ORF Sequence $2500.00
XM_005253287, 578822734 XP_005253344, 530398968 ATP-binding cassette sub-family C member 9 isoform X4 ORF Sequence $2500.00
XM_005253288, 578822733 XP_005253345, 530398970 ATP-binding cassette sub-family C member 9 isoform X5 ORF Sequence $2500.00
XM_005253289, 578822735 XP_005253346, 530398972 ATP-binding cassette sub-family C member 9 isoform X6 ORF Sequence $2500.00
XM_005253290, 578822738 XP_005253347, 530398974 ATP-binding cassette sub-family C member 9 isoform X7 ORF Sequence $2500.00
XM_005253291, 578822739 XP_005253348, 530398976 ATP-binding cassette sub-family C member 9 isoform X8 ORF Sequence $1500.00
XM_006719025, 578822736 XP_006719088, 578822737 ATP-binding cassette sub-family C member 9 isoform X9 ORF Sequence $2500.00
KEGG
hsa02010ABC transporters
Reactome
REACT_15518Transmembrane transport of small molecules
REACT_15480ABC-family proteins mediated transport
REACT_13685Neuronal System
REACT_75775ATP sensitive Potassium channels
REACT_75908Potassium Channels
REACT_75918Inwardly rectifying K+ channels
Homo sapiens (human)ABCC9NP_005682.2
Pan troglodytes (chimpanzee)ABCC9XP_001149414.1
Macaca mulatta (Rhesus monkey)ABCC9XP_001098888.1
Canis lupus familiaris (dog)ABCC9XP_852746.1
Bos taurus (cattle)ABCC9XP_005207020.1
Mus musculus (house mouse)Abcc9NP_035641.1
Rattus norvegicus (Norway rat)Abcc9NP_037172.2
Gallus gallus (chicken)ABCC9XP_004938045.1
Danio rerio (zebrafish)abcc9NP_001025325.1
Drosophila melanogaster (fruit fly)SurNP_477472.2
Xenopus (Silurana) tropicalis (western clawed frog)abcc9XP_004920363.1
Process
IDNameEvidence
GO:0006200ATP catabolic processIEA
GO:0006813potassium ion transportTAS
GO:0007165signal transductionIEA
GO:0007165signal transductionISS
GO:0007165signal transductionTAS
GO:0007268synaptic transmissionTAS
GO:0010107potassium ion importISS
GO:0051607defense response to virusIMP
GO:0055085transmembrane transportTAS
Component
IDNameEvidence
GO:0005886plasma membraneTAS
GO:0008076voltage-gated potassium channel complexIDA
GO:0008282ATP-sensitive potassium channel complexISS
GO:0030017sarcomereIEA
GO:0042383sarcolemmaIEA
Function
IDNameEvidence
GO:0005215transporter activityTAS
GO:0005267potassium channel activityIEA
GO:0005524ATP bindingIEA
GO:0008281sulfonylurea receptor activityISS
GO:0015459potassium channel regulator activityISS
GO:0042626ATPase activity, coupled to transmembrane movement of substancesIEA
GO:0044325ion channel bindingIPI
GeneCards ABCC9
UniProt O60706
Vega OTTHUMG00000169094
MIM 601439
Ensembl ENSG00000069431
HGNC 60
HPRD 03258

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the ABCC9 gene?

The ABCC9 gene provides instructions for making the sulfonylurea receptor 2 (SUR2) protein. This protein forms one part (subunit) of a channel that transports charged atoms of potassium (potassium ions) across cell membranes. Each of these channels consists of eight subunits: four SUR2 proteins and four proteins produced from either the KCNJ8 or KCNJ11 gene. The SUR2 subunits regulate the activity of the channel, determining whether it is open or closed.

Channels made with the SUR2 protein are known as ATP-sensitive potassium (K-ATP) channels. The channels open and close in response to the amount of ATP, the cell's main energy source, inside the cell. The resulting transport of potassium ions is part of a complex network of signals that relay chemical messages into and out of cells.

Although K-ATP channels are present in cells and tissues throughout the body, the highest levels of SUR2-containing channels are found in skeletal and heart (cardiac) muscle. These channels indirectly help regulate the concentration of calcium ions in cells. This regulation is essential for normal heart function. The function of these channels in other tissues is unclear.

Interactant

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