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LPAR6 lysophosphatidic acid receptor 6 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001162497 Homo sapiens lysophosphatidic acid receptor 6 (LPAR6), transcript variant 2, mRNA. GenEZ ORF Cloning In-stock $418.00 $369.00 10
NM_001162498 Homo sapiens lysophosphatidic acid receptor 6 (LPAR6), transcript variant 3, mRNA. GenEZ ORF Cloning In-stock $418.00 $369.00 10
NM_005767 Homo sapiens lysophosphatidic acid receptor 6 (LPAR6), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $418.00 $369.00 10

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Related Services

Gene Symbol LPAR6
Entrez Gene ID 10161
Full Name lysophosphatidic acid receptor 6
Synonyms ARWH1, HYPT8, LAH3, P2RY5, P2Y5
General protein information
Preferred Names
lysophosphatidic acid receptor 6
Names
lysophosphatidic acid receptor 6
LPA-6
LPA receptor 6
P2Y purinoceptor 5
purinergic receptor 5
G-protein coupled purinergic receptor P2Y5
RB intron encoded G-protein coupled receptor
oleoyl-L-alpha-lysophosphatidic acid receptor
purinergic receptor P2Y, G-protein coupled, 5
purinergic receptor P2Y G protein-coupled protein 5
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

13

13q14

Summary The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene aligns with an internal intron of the retinoblastoma susceptibility gene in the reverse orientation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009].
Disorder

MIM: 609239

Hypotrichosis, localized, autosomal recessive, 3, 611452 (3);

mRNA Protein Product Sequence Price Select
NM_001162497, 241982705 NP_001155969, 241982706 lysophosphatidic acid receptor 6 ORF Sequence $269.00
NM_001162498, 241982707 NP_001155970, 241982708 lysophosphatidic acid receptor 6 ORF Sequence $269.00
NM_005767, 241982698 NP_005758, 33695113 lysophosphatidic acid receptor 6 ORF Sequence $269.00
KEGG
hsa04080Neuroactive ligand-receptor interaction
hsa04151PI3K-Akt signaling pathway
WikiPathways
WP80Nucleotide GPCRs
WP455GPCRs, Class A Rhodopsin-like
Reactome
REACT_19184GPCR downstream signaling
REACT_18283G alpha (q) signalling events
REACT_14797Signaling by GPCR
REACT_18342Nucleotide-like (purinergic) receptors
REACT_14828Class A/1 (Rhodopsin-like receptors)
REACT_18289P2Y receptors
REACT_21340GPCR ligand binding
REACT_111102Signal Transduction
REACT_120966Gastrin-CREB signalling pathway via PKC and MAPK
Homo sapiens (human)LPAR6NP_001155969.1
Pan troglodytes (chimpanzee)LPAR6XP_003339299.1
Macaca mulatta (Rhesus monkey)LPAR6XP_001100838.1
Canis lupus familiaris (dog)LPAR6XP_003639861.1
Bos taurus (cattle)LPAR6NP_001094754.1
Mus musculus (house mouse)Lpar6NP_780325.1
Rattus norvegicus (Norway rat)Lpar6NP_001039308.1
Gallus gallus (chicken)LPAR6NP_990530.2
Danio rerio (zebrafish)lpar6aNP_001073524.1
Xenopus (Silurana) tropicalis (western clawed frog)lpar6XP_002935149.1
Process
IDNameEvidence
GO:0007186G-protein coupled receptor signaling pathwayIEA
Component
IDNameEvidence
GO:0005886plasma membraneIDA
GO:0005886plasma membraneTAS
GO:0016021integral component of membraneIEA
Function
IDNameEvidence
GO:0004930G-protein coupled receptor activityIEA
GeneCards LPAR6
UniProt P43657, B3KVQ5
Vega OTTHUMG00000016895
MIM 609239
Ensembl ENSG00000139679
HGNC 15520
HPRD 16465

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the LPAR6 gene?

The LPAR6 gene provides instructions for making a protein called lysophosphatidic acid receptor 6 (LPA6). This protein functions as a receptor. Receptor proteins have particular sites into which certain other proteins, called ligands, fit like keys into locks. A specific fat called lysophosphatidic acid (LPA) is the ligand for the LPA6 protein. LPA can attach to many receptors, but LPA6 is the only LPA receptor found in hair follicles. Hair follicles are specialized structures in the skin where hair growth occurs. As the cells in the hair follicle divide, the hair strand (shaft) is pushed upward and extends beyond the skin, causing the hair to grow. The LPA6 protein is also found in the outermost layer of skin (the epidermis). Attachment of LPA to LPA6 helps regulate the growth and division (proliferation) and maturation (differentiation) of cells in the hair follicle.

Interactant

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