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CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_004064 Homo sapiens cyclin-dependent kinase inhibitor 1B (p27, Kip1) (CDKN1B), mRNA. GenEZ ORF Cloning In-stock $308.00 $259.00 10

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Gene Symbol CDKN1B
Entrez Gene ID 1027
Full Name cyclin-dependent kinase inhibitor 1B (p27, Kip1)
Synonyms CDKN4, KIP1, MEN1B, MEN4, P27KIP1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

12

12p13.1-p12

Summary This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. [provided by RefSeq, Jul 2008].
Disorder

MIM: 600778

Multiple endocrine neoplasia, type IV, 610755 (3)

mRNA Protein Product Sequence Price Select
NM_004064, 207113192 NP_004055, 4757962 cyclin-dependent kinase inhibitor 1B ORF Sequence $159.00
KEGG
hsa05203Viral carcinogenesis
hsa04066HIF-1 signaling pathway
hsa04012ErbB signaling pathway
hsa05200Pathways in cancer
hsa05220Chronic myeloid leukemia
hsa04151PI3K-Akt signaling pathway
hsa05202Transcriptional misregulation in cancer
hsa05162Measles
hsa05161Hepatitis B
hsa04110Cell cycle
hsa05222Small cell lung cancer
hsa05215Prostate cancer
hsa05169Epstein-Barr virus infection
Pathway Interaction Database
cmyb_pathwayC-MYB transcription factor network
avb3_integrin_pathwayIntegrins in angiogenesis
rb_1pathwayRegulation of retinoblastoma protein
telomerasepathwayRegulation of Telomerase
myc_represspathwayValidated targets of C-MYC transcriptional repression
e2f_pathwayE2F transcription factor network
hes_heypathwayNotch-mediated HES/HEY network
pi3kciaktpathwayClass I PI3K signaling events mediated by Akt
rhoa_reg_pathwayRegulation of RhoA activity
rhoa_pathwayRhoA signaling pathway
foxopathwayFoxO family signaling
hnf3apathwayFOXA1 transcription factor network
WikiPathways
WP2377Integrated Pancreatic Cancer Pathway
WP2256Integrated Pancreatic Cancer Pathway
WP2032TSH signaling pathway
WP673ErbB signaling pathway
WP34Ovarian Infertility Genes
WP45G1 to S cell cycle control
WP2374Oncostatin M Signaling Pathway
WP2261Signaling Pathways in Glioblastoma
WP615Senescence and Autophagy
WP710DNA damage response (only ATM dependent)
WP127IL-5 Signaling Pathway
WP707DNA damage response
WP179Cell cycle
WP1545miRNAs involved in DDR
Reactome
REACT_111040Signaling by SCF-KIT
REACT_9003SCF(Skp2)-mediated degradation of p27/p21
REACT_383DNA Replication
REACT_9029Cyclin A:Cdk2-associated events at S phase entry
REACT_120736Signaling by FGFR in disease
REACT_12464PI3K/AKT activation
REACT_21270PI-3K cascade
REACT_115961PI3K events in ERBB4 signaling
REACT_1783G1/S Transition
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_115755Signaling by ERBB2
REACT_1625p53-Dependent G1 DNA Damage Response
REACT_6900Immune System
REACT_115596Signaling by ERBB4
REACT_147694DAP12 interactions
REACT_207Removal of licensing factors from origins
REACT_829Regulation of DNA replication
REACT_1156Orc1 removal from chromatin
REACT_2254G1/S DNA Damage Checkpoints
REACT_115566Cell Cycle
REACT_1574Cyclin E associated events during G1/S transition
REACT_147723PI3K/AKT Signaling in Cancer
REACT_9417Signaling by EGFR
REACT_6802Innate Immune System
REACT_2014Synthesis of DNA
REACT_2148Switching of origins to a post-replicative state
REACT_11061Signalling by NGF
REACT_115871Signaling by EGFR in Cancer
REACT_147814DAP12 signaling
REACT_118638Downstream Signaling Events Of B Cell Receptor (BCR)
REACT_17025Downstream signal transduction
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_152Cell Cycle, Mitotic
REACT_821Cyclin D associated events in G1
REACT_75774Adaptive Immune System
REACT_16888Signaling by PDGF
REACT_12578GAB1 signalosome
REACT_9470Signaling by FGFR
REACT_1590G1 Phase
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_1538Cell Cycle Checkpoints
REACT_116125Disease
REACT_21272Downstream signaling of activated FGFR
REACT_899S Phase
REACT_75829PIP3 activates AKT signaling
REACT_116008PI3K events in ERBB2 signaling
REACT_111102Signal Transduction
REACT_12564AKT phosphorylates targets in the cytosol
REACT_85p53-Dependent G1/S DNA damage checkpoint
REACT_21267Mitotic G1-G1/S phases
Homo sapiens (human)CDKN1BNP_004055.1
Pan troglodytes (chimpanzee)CDKN1BXP_522347.3
Macaca mulatta (Rhesus monkey)CDKN1BXP_001085433.1
Canis lupus familiaris (dog)CDKN1BNP_001002957.1
Bos taurus (cattle)CDKN1BNP_001093816.1
Mus musculus (house mouse)Cdkn1bNP_034005.2
Rattus norvegicus (Norway rat)Cdkn1bNP_113950.2
Gallus gallus (chicken)CDKN1BNP_989587.1
Danio rerio (zebrafish)cdkn1bbNP_997957.1
Danio rerio (zebrafish)LOC100534692XP_003201420.1
GeneCards CDKN1B
PDB 2AST, 1JSU, 1H27
UniProt Q6I9V6, P46527
MIM 600778
Ensembl ENSG00000111276
HGNC 1785
HPRD 02867

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
cyclin-dependent kinase inhibitor 1B
Names
cyclin-dependent kinase inhibitor 1B

Interactant



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