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CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu27895 NM_004064 Homo sapiens cyclin-dependent kinase inhibitor 1B (p27, Kip1) (CDKN1B), mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu27895C NM_004064 Homo sapiens cyclin-dependent kinase inhibitor 1B (p27, Kip1) (CDKN1B), mRNA. Customized vector In-stock 5-7 $149.00

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Gene Symbol CDKN1B
Entrez Gene ID 1027
Full Name cyclin-dependent kinase inhibitor 1B (p27, Kip1)
Synonyms CDKN4, KIP1, MEN1B, MEN4, P27KIP1
General protein information
Preferred Names
cyclin-dependent kinase inhibitor 1B
Names
cyclin-dependent kinase inhibitor 1B
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

12

12p13.1-p12

Summary This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). [provided by RefSeq, Apr 2014].
Disorder

MIM: 600778

Multiple endocrine neoplasia, type IV, 610755 (3)

mRNA Protein Product Sequence Price Select
NM_004064, 584458479 NP_004055, 4757962 cyclin-dependent kinase inhibitor 1B ORF Sequence $159.00
KEGG
hsa04012ErbB signaling pathway
hsa04110Cell cycle
hsa05215Prostate cancer
hsa05222Small cell lung cancer
hsa05220Chronic myeloid leukemia
hsa05200Pathways in cancer
hsa05162Measles
hsa04151PI3K-Akt signaling pathway
hsa05161Hepatitis B
hsa04066HIF-1 signaling pathway
hsa05202Transcriptional misregulation in cancer
hsa05169Epstein-Barr virus infection
hsa05203Viral carcinogenesis
hsa05206MicroRNAs in cancer
hsa04068FoxO signaling pathway
WikiPathways
WP707DNA damage response
WP127IL-5 Signaling Pathway
WP615Senescence and Autophagy
WP34Ovarian Infertility Genes
WP45G1 to S cell cycle control
WP179Cell cycle
WP710DNA damage response (only ATM dependent)
WP673ErbB signaling pathway
WP1545miRNAs involved in DDR
WP2377Integrated Pancreatic Cancer Pathway
WP2374Oncostatin M Signaling Pathway
WP2261Signaling Pathways in Glioblastoma
WP2032TSH signaling pathway
WP2431Spinal Cord Injury
WP2100AhR pathway
WP2446RB in Cancer
Pathway Interaction Database
rb_1pathwayRegulation of retinoblastoma protein
avb3_integrin_pathwayIntegrins in angiogenesis
telomerasepathwayRegulation of Telomerase
hnf3apathwayFOXA1 transcription factor network
pi3kciaktpathwayClass I PI3K signaling events mediated by Akt
foxopathwayFoxO family signaling
e2f_pathwayE2F transcription factor network
cmyb_pathwayC-MYB transcription factor network
rhoa_reg_pathwayRegulation of RhoA activity
rhoa_pathwayRhoA signaling pathway
hes_heypathwayNotch-mediated HES/HEY network
myc_represspathwayValidated targets of C-MYC transcriptional repression
Reactome
REACT_1538Cell Cycle Checkpoints
REACT_2254G1/S DNA Damage Checkpoints
REACT_152Cell Cycle, Mitotic
REACT_1574Cyclin E associated events during G1/S transition
REACT_85p53-Dependent G1/S DNA damage checkpoint
REACT_1625p53-Dependent G1 DNA Damage Response
REACT_9003SCF(Skp2)-mediated degradation of p27/p21
REACT_2148Switching of origins to a post-replicative state
REACT_1783G1/S Transition
REACT_9029Cyclin A:Cdk2-associated events at S phase entry
REACT_899S Phase
REACT_2014Synthesis of DNA
REACT_1590G1 Phase
REACT_821Cyclin D associated events in G1
REACT_1156Orc1 removal from chromatin
REACT_207Removal of licensing factors from origins
REACT_829Regulation of DNA replication
REACT_383DNA Replication
REACT_9470Signaling by FGFR
REACT_12578GAB1 signalosome
REACT_9417Signaling by EGFR
REACT_16888Signaling by PDGF
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_17025Downstream signal transduction
REACT_11061Signalling by NGF
REACT_12464PI3K/AKT activation
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_12564AKT phosphorylates targets in the cytosol
REACT_21272Downstream signaling of activated FGFR
REACT_21267Mitotic G1-G1/S phases
REACT_21270PI-3K cascade
REACT_75774Adaptive Immune System
REACT_75829PIP3 activates AKT signaling
REACT_111102Signal Transduction
REACT_111040Signaling by SCF-KIT
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_147723PI3K/AKT Signaling in Cancer
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_115596Signaling by ERBB4
REACT_115755Signaling by ERBB2
REACT_116008PI3K events in ERBB2 signaling
REACT_116125Disease
REACT_115566Cell Cycle
REACT_115871Signaling by EGFR in Cancer
REACT_115961PI3K events in ERBB4 signaling
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_120736Signaling by FGFR in disease
REACT_120956Cellular responses to stress
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_163769Role of LAT2/NTAL/LAB on calcium mobilization
REACT_169274Cellular Senescence
REACT_169168Senescence-Associated Secretory Phenotype (SASP)
REACT_169185DNA Damage/Telomere Stress Induced Senescence
Homo sapiens (human)CDKN1BNP_004055.1
Pan troglodytes (chimpanzee)CDKN1BXP_522347.3
Macaca mulatta (Rhesus monkey)CDKN1BXP_001085433.1
Canis lupus familiaris (dog)CDKN1BNP_001002957.1
Bos taurus (cattle)CDKN1BNP_001093816.1
Mus musculus (house mouse)Cdkn1bNP_034005.2
Rattus norvegicus (Norway rat)Cdkn1bNP_113950.2
Gallus gallus (chicken)CDKN1BNP_989587.1
Danio rerio (zebrafish)cdkn1bbNP_997957.1
Danio rerio (zebrafish)LOC100534692XP_003201420.1
Process
IDNameEvidence
GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activityTAS
GO:0000082G1/S transition of mitotic cell cycleIDA
GO:0000082G1/S transition of mitotic cell cycleTAS
GO:0000278mitotic cell cycleTAS
GO:0001666response to hypoxiaIEA
GO:0006813potassium ion transportIEA
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic processIDA
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestTAS
GO:0007050cell cycle arrestIMP
GO:0007173epidermal growth factor receptor signaling pathwayTAS
GO:0007605sensory perception of soundIEA
GO:0008284positive regulation of cell proliferationIEA
GO:0008285negative regulation of cell proliferationIDA
GO:0008285negative regulation of cell proliferationIMP
GO:0008543fibroblast growth factor receptor signaling pathwayTAS
GO:0009749response to glucoseIEA
GO:0010942positive regulation of cell deathIDA
GO:0030308negative regulation of cell growthIDA
GO:0031116positive regulation of microtubule polymerizationIEA
GO:0032355response to estradiolIEA
GO:0033673negative regulation of kinase activityIDA
GO:0038095Fc-epsilon receptor signaling pathwayTAS
GO:0042326negative regulation of phosphorylationIDA
GO:0042493response to drugIEA
GO:0043066negative regulation of apoptotic processIEA
GO:0043200response to amino acidIEA
GO:0043434response to peptide hormoneIEA
GO:0045087innate immune responseTAS
GO:0045732positive regulation of protein catabolic processIDA
GO:0045736negative regulation of cyclin-dependent protein serine/threonine kinase activityIEA
GO:0045892negative regulation of transcription, DNA-templatedIDA
GO:0045930negative regulation of mitotic cell cycleIDA
GO:0046686response to cadmium ionIEA
GO:0048011neurotrophin TRK receptor signaling pathwayTAS
GO:0048015phosphatidylinositol-mediated signalingTAS
GO:0048102autophagic cell deathIDA
GO:0048839inner ear developmentIEA
GO:0051271negative regulation of cellular component movementIEA
GO:0060770negative regulation of epithelial cell proliferation involved in prostate gland developmentIEA
GO:0071236cellular response to antibioticIEA
GO:0071285cellular response to lithium ionIDA
GO:0071407cellular response to organic cyclic compoundIEA
GO:0071850mitotic cell cycle arrestIDA
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005654nucleoplasmTAS
GO:0005737cytoplasmIDA
GO:0005768endosomeIEA
GO:0005829cytosolTAS
GO:0043234protein complexIEA
Function
IDNameEvidence
GO:0004861cyclin-dependent protein serine/threonine kinase inhibitor activityIEA
GO:0005072transforming growth factor beta receptor, cytoplasmic mediator activityTAS
GO:0005515protein bindingIPI
GO:0008656cysteine-type endopeptidase activator activity involved in apoptotic processIDA
GO:0019903protein phosphatase bindingIPI
GO:0030544Hsp70 protein bindingIEA
GO:0032403protein complex bindingIEA
GO:0051087chaperone bindingIEA
GeneCards CDKN1B
PDB 2AST, 1JSU, 1H27
UniProt Q6I9V6, P46527
Vega OTTHUMG00000149914
MIM 600778
Ensembl ENSG00000111276
HGNC 1785
HPRD 02867

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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