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CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000076 Homo sapiens cyclin-dependent kinase inhibitor 1C (p57, Kip2) (CDKN1C), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand TBD TBD
NM_001122630 Homo sapiens cyclin-dependent kinase inhibitor 1C (p57, Kip2) (CDKN1C), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand TBD TBD
NM_001122631 Homo sapiens cyclin-dependent kinase inhibitor 1C (p57, Kip2) (CDKN1C), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand TBD TBD
XM_005252731 PREDICTED: Homo sapiens cyclin-dependent kinase inhibitor 1C (p57, Kip2) (CDKN1C), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand TBD TBD
XM_005252732 PREDICTED: Homo sapiens cyclin-dependent kinase inhibitor 1C (p57, Kip2) (CDKN1C), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $399.00 14
XM_006725125 PREDICTED: Homo sapiens cyclin-dependent kinase inhibitor 1C (p57, Kip2) (CDKN1C), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand TBD TBD
XM_006725126 PREDICTED: Homo sapiens cyclin-dependent kinase inhibitor 1C (p57, Kip2) (CDKN1C), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $399.00 14

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Related Services

Gene Symbol CDKN1C
Entrez Gene ID 1028
Full Name cyclin-dependent kinase inhibitor 1C (p57, Kip2)
Synonyms BWCR, BWS, KIP2, WBS, p57, p57Kip2
General protein information
Preferred Names
cyclin-dependent kinase inhibitor 1C
Names
cyclin-dependent kinase inhibitor 1C
cyclin-dependent kinase inhibitor p57
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11p15.5

Summary This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010].
Disorder

MIM: 600856

Beckwith-Wiedemann syndrome, 130650 (3)

mRNA Protein Product Sequence Price Select
NM_000076, 169790897 NP_000067, 4557441 cyclin-dependent kinase inhibitor 1C isoform a ORF Sequence $400.00
NM_001122630, 169790898 NP_001116102, 169790899 cyclin-dependent kinase inhibitor 1C isoform b ORF Sequence $300.00
NM_001122631, 169790902 NP_001116103, 169790903 cyclin-dependent kinase inhibitor 1C isoform b ORF Sequence $300.00
XM_005252731, 530394945 XP_005252788, 530394946 cyclin-dependent kinase inhibitor 1C isoform X1 ORF Sequence $400.00
XM_005252732, 578820274 XP_005252789, 530394948 cyclin-dependent kinase inhibitor 1C isoform X2 ORF Sequence $250.00
XM_006725125, 578839817 XP_006725188, 578839818 cyclin-dependent kinase inhibitor 1C isoform X1 ORF Sequence $400.00
XM_006725126, 578839819 XP_006725189, 578839820 cyclin-dependent kinase inhibitor 1C isoform X2 ORF Sequence $250.00
KEGG
hsa04110Cell cycle
WikiPathways
WP45G1 to S cell cycle control
WP474Endochondral Ossification
Homo sapiens (human)CDKN1CNP_000067.1
Macaca mulatta (Rhesus monkey)CDKN1CXP_001117302.2
Process
IDNameEvidence
GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activityTAS
GO:0000080mitotic G1 phaseTAS
GO:0000122negative regulation of transcription from RNA polymerase II promoterIEA
GO:0001890placenta developmentIEA
GO:0007050cell cycle arrestIEA
GO:0008285negative regulation of cell proliferationTAS
GO:0030511positive regulation of transforming growth factor beta receptor signaling pathwayIMP
GO:0033673negative regulation of kinase activityIDA
GO:0042326negative regulation of phosphorylationIDA
GO:0042551neuron maturationIEA
GO:0045892negative regulation of transcription, DNA-templatedIDA
GO:0045893positive regulation of transcription, DNA-templatedIGI
GO:0050680negative regulation of epithelial cell proliferationIMP
GO:0071901negative regulation of protein serine/threonine kinase activityIEA
GO:0071901negative regulation of protein serine/threonine kinase activityTAS
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005737cytoplasmIDA
Function
IDNameEvidence
GO:0004861cyclin-dependent protein serine/threonine kinase inhibitor activityIEA
GO:0005515protein bindingIPI
GeneCards CDKN1C
UniProt P49918
Vega OTTHUMG00000010040
MIM 600856
Ensembl ENSG00000129757
HGNC 1786
HPRD 02913

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the CDKN1C gene?

The CDKN1C gene provides instructions for making a protein that helps regulate growth. This protein acts as a tumor suppressor, which means that it keeps cells from growing and dividing too fast or in an uncontrolled way. It also is involved in controlling growth before birth, preventing the developing fetus from becoming too large.

People generally inherit one copy of a gene from their mother and one copy from their father. For most genes, both copies are fully turned on (active) in cells. The CDKN1C gene, however, is most active when it is inherited from a person's mother. The copy of CDKN1C inherited from a person's father is active at much lower levels in most tissues. This sort of parent-specific difference in gene activation is caused by a phenomenon called genomic imprinting. When genomic imprinting reduces the activity of the copy of a gene inherited from the father, that gene is said to be paternally imprinted.

CDKN1C is part of a cluster of genes on the short (p) arm of chromosome 11 that undergo genomic imprinting. A nearby region of DNA known as imprinting center 2 (ICR2) or KvDMR controls the parent-specific genomic imprinting of CDKN1C and several other genes thought to help regulate growth.

Interactant

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