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CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu26977 NM_001122630 Homo sapiens cyclin-dependent kinase inhibitor 1C (p57, Kip2) (CDKN1C), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu26977 NM_001122631 Homo sapiens cyclin-dependent kinase inhibitor 1C (p57, Kip2) (CDKN1C), transcript variant 3, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu27234 NM_000076 Homo sapiens cyclin-dependent kinase inhibitor 1C (p57, Kip2) (CDKN1C), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu27234 XM_005252731 PREDICTED: Homo sapiens cyclin-dependent kinase inhibitor 1C (p57, Kip2) (CDKN1C), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu44738 XM_005252732 PREDICTED: Homo sapiens cyclin-dependent kinase inhibitor 1C (p57, Kip2) (CDKN1C), transcript variant X2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu54644 XM_006725125 PREDICTED: Homo sapiens cyclin-dependent kinase inhibitor 1C (p57, Kip2) (CDKN1C), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu44738 XM_006725126 PREDICTED: Homo sapiens cyclin-dependent kinase inhibitor 1C (p57, Kip2) (CDKN1C), transcript variant X2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu26977C NM_001122630 Homo sapiens cyclin-dependent kinase inhibitor 1C (p57, Kip2) (CDKN1C), transcript variant 2, mRNA. Customized vector On-demand 7-9 $209.00
OHu26977C NM_001122631 Homo sapiens cyclin-dependent kinase inhibitor 1C (p57, Kip2) (CDKN1C), transcript variant 3, mRNA. Customized vector On-demand 7-9 $209.00
OHu27234C NM_000076 Homo sapiens cyclin-dependent kinase inhibitor 1C (p57, Kip2) (CDKN1C), transcript variant 1, mRNA. Customized vector On-demand 7-9 $209.00
OHu27234C XM_005252731 PREDICTED: Homo sapiens cyclin-dependent kinase inhibitor 1C (p57, Kip2) (CDKN1C), transcript variant X1, mRNA. Customized vector On-demand 7-9 $209.00
OHu44738C XM_005252732 PREDICTED: Homo sapiens cyclin-dependent kinase inhibitor 1C (p57, Kip2) (CDKN1C), transcript variant X2, mRNA. Customized vector On-demand 7-9 $209.00
OHu54644C XM_006725125 PREDICTED: Homo sapiens cyclin-dependent kinase inhibitor 1C (p57, Kip2) (CDKN1C), transcript variant X1, mRNA. Customized vector On-demand 7-9 $209.00
OHu44738C XM_006725126 PREDICTED: Homo sapiens cyclin-dependent kinase inhibitor 1C (p57, Kip2) (CDKN1C), transcript variant X2, mRNA. Customized vector On-demand 7-9 $209.00

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Gene Symbol CDKN1C
Entrez Gene ID 1028
Full Name cyclin-dependent kinase inhibitor 1C (p57, Kip2)
Synonyms BWCR, BWS, KIP2, WBS, p57, p57Kip2
General protein information
Preferred Names
cyclin-dependent kinase inhibitor 1C
Names
cyclin-dependent kinase inhibitor 1C
cyclin-dependent kinase inhibitor p57
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11p15.5

Summary This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010].
Disorder

MIM: 600856

Beckwith-Wiedemann syndrome, 130650 (3)

mRNA Protein Product Sequence Price Select
NM_000076, 169790897 NP_000067, 4557441 cyclin-dependent kinase inhibitor 1C isoform a ORF Sequence $400.00
NM_001122630, 169790898 NP_001116102, 169790899 cyclin-dependent kinase inhibitor 1C isoform b ORF Sequence $300.00
NM_001122631, 169790902 NP_001116103, 169790903 cyclin-dependent kinase inhibitor 1C isoform b ORF Sequence $300.00
XM_005252731, 530394945 XP_005252788, 530394946 cyclin-dependent kinase inhibitor 1C isoform X1 ORF Sequence $400.00
XM_005252732, 578820274 XP_005252789, 530394948 cyclin-dependent kinase inhibitor 1C isoform X2 ORF Sequence $250.00
XM_006725125, 578839817 XP_006725188, 578839818 cyclin-dependent kinase inhibitor 1C isoform X1 ORF Sequence $400.00
XM_006725126, 578839819 XP_006725189, 578839820 cyclin-dependent kinase inhibitor 1C isoform X2 ORF Sequence $250.00
KEGG
hsa04110Cell cycle
WikiPathways
WP45G1 to S cell cycle control
WP474Endochondral Ossification
Homo sapiens (human)CDKN1CNP_000067.1
Macaca mulatta (Rhesus monkey)CDKN1CXP_001117302.2
Process
IDNameEvidence
GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activityTAS
GO:0000080mitotic G1 phaseTAS
GO:0000122negative regulation of transcription from RNA polymerase II promoterIEA
GO:0001890placenta developmentIEA
GO:0007050cell cycle arrestIEA
GO:0008285negative regulation of cell proliferationTAS
GO:0030511positive regulation of transforming growth factor beta receptor signaling pathwayIMP
GO:0033673negative regulation of kinase activityIDA
GO:0042326negative regulation of phosphorylationIDA
GO:0042551neuron maturationIEA
GO:0045892negative regulation of transcription, DNA-templatedIDA
GO:0045893positive regulation of transcription, DNA-templatedIGI
GO:0050680negative regulation of epithelial cell proliferationIMP
GO:0071901negative regulation of protein serine/threonine kinase activityIEA
GO:0071901negative regulation of protein serine/threonine kinase activityTAS
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005737cytoplasmIDA
Function
IDNameEvidence
GO:0004861cyclin-dependent protein serine/threonine kinase inhibitor activityIEA
GO:0005515protein bindingIPI
GeneCards CDKN1C
UniProt P49918
Vega OTTHUMG00000010040
MIM 600856
Ensembl ENSG00000129757
HGNC 1786
HPRD 02913

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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