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CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_004936 Homo sapiens cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) (CDKN2B), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $248.00 $199.00 TBD
NM_078487 Homo sapiens cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) (CDKN2B), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand TBD TBD

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Related Services

Gene Symbol CDKN2B
Entrez Gene ID 1030
Full Name cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
Synonyms CDK4I, INK4B, MTS2, P15, TP15, p15INK4b
General protein information
Preferred Names
cyclin-dependent kinase 4 inhibitor B
Names
cyclin-dependent kinase 4 inhibitor B
MTS-2
p14-INK4b
p14_INK4B
p15-INK4b
p15_INK4B
CDK4B inhibitor
p14_CDK inhibitor
p15 CDK inhibitor
CDK inhibitory protein
multiple tumor suppressor 2
cyclin-dependent kinases 4 and 6 binding protein
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

9

9p21

Summary This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008].
Disorder

MIM: 600431

mRNA Protein Product Sequence Price Select
NM_004936, 47132608 NP_004927, 17981694 cyclin-dependent kinase 4 inhibitor B isoform 1 ORF Sequence $99.00
NM_078487, 47132609 NP_511042, 17981696 cyclin-dependent kinase 4 inhibitor B isoform 2 ORF Sequence $150.00
KEGG
hsa04110Cell cycle
hsa04350TGF-beta signaling pathway
hsa05222Small cell lung cancer
hsa05200Pathways in cancer
hsa05166HTLV-I infection
hsa05203Viral carcinogenesis
hsa04068FoxO signaling pathway
WikiPathways
WP45G1 to S cell cycle control
WP2377Integrated Pancreatic Cancer Pathway
WP2261Signaling Pathways in Glioblastoma
Pathway Interaction Database
smad2_3nuclearpathwayRegulation of nuclear SMAD2/3 signaling
myc_represspathwayValidated targets of C-MYC transcriptional repression
Reactome
REACT_152Cell Cycle, Mitotic
REACT_1590G1 Phase
REACT_821Cyclin D associated events in G1
REACT_12627Generic Transcription Pathway
REACT_71Gene Expression
REACT_6844Signaling by TGF-beta Receptor Complex
REACT_21267Mitotic G1-G1/S phases
REACT_111102Signal Transduction
REACT_116125Disease
REACT_115566Cell Cycle
REACT_120734SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
REACT_120956Cellular responses to stress
REACT_121061Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
REACT_169274Cellular Senescence
REACT_169168Senescence-Associated Secretory Phenotype (SASP)
REACT_169436Oxidative Stress Induced Senescence
REACT_169103SMAD2/3 Phosphorylation Motif Mutants in Cancer
REACT_169263TGFBR1 KD Mutants in Cancer
REACT_169192TGFBR2 MSI Frameshift Mutants in Cancer
REACT_169440TGFBR2 Kinase Domain Mutants in Cancer
REACT_169165SMAD2/3 MH2 Domain Mutants in Cancer
REACT_169107SMAD4 MH2 Domain Mutants in Cancer
REACT_169311Loss of Function of TGFBR1 in Cancer
REACT_169122Signaling by TGF-beta Receptor Complex in Cancer
REACT_169325Oncogene Induced Senescence
REACT_169435Loss of Function of TGFBR2 in Cancer
REACT_169219Loss of Function of SMAD4 in Cancer
REACT_169398Loss of Function of SMAD2/3 in Cancer
REACT_169445TGFBR1 LBD Mutants in Cancer
Homo sapiens (human)CDKN2BNP_004927.2
Pan troglodytes (chimpanzee)CDKN2BXP_003312069.1
Macaca mulatta (Rhesus monkey)CDKN2BXP_001107263.1
Canis lupus familiaris (dog)CDKN2BNP_001139741.1
Bos taurus (cattle)CDKN2BNP_001069362.1
Mus musculus (house mouse)Cdkn2bNP_031696.1
Rattus norvegicus (Norway rat)Cdkn2bNP_570825.1
Gallus gallus (chicken)CDKN2BNP_989764.1
Process
IDNameEvidence
GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activityIDA
GO:0000086G2/M transition of mitotic cell cycleIMP
GO:0000278mitotic cell cycleTAS
GO:0001889liver developmentIEA
GO:0006351transcription, DNA-templatedTAS
GO:0006367transcription initiation from RNA polymerase II promoterTAS
GO:0007050cell cycle arrestIMP
GO:0007093mitotic cell cycle checkpointIMP
GO:0007179transforming growth factor beta receptor signaling pathwayTAS
GO:0007568agingIEA
GO:0008285negative regulation of cell proliferationIMP
GO:0010467gene expressionTAS
GO:0014070response to organic cyclic compoundIEA
GO:0030219megakaryocyte differentiationIEP
GO:0030511positive regulation of transforming growth factor beta receptor signaling pathwayIMP
GO:0030858positive regulation of epithelial cell differentiationIEA
GO:0031668cellular response to extracellular stimulusIMP
GO:0031670cellular response to nutrientIMP
GO:0034097response to cytokineIEA
GO:0042326negative regulation of phosphorylationIDA
GO:0045944positive regulation of transcription from RNA polymerase II promoterTAS
GO:0048536spleen developmentIEA
GO:0050680negative regulation of epithelial cell proliferationIMP
GO:0071901negative regulation of protein serine/threonine kinase activityIDA
GO:0071901negative regulation of protein serine/threonine kinase activityNAS
GO:2000134negative regulation of G1/S transition of mitotic cell cycleIEA
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005730nucleolusIDA
GO:0005737cytoplasmIDA
GO:0005829cytosolTAS
Function
IDNameEvidence
GO:0004861cyclin-dependent protein serine/threonine kinase inhibitor activityIDA
GO:0004861cyclin-dependent protein serine/threonine kinase inhibitor activityNAS
GO:0005515protein bindingIPI
GO:0019901protein kinase bindingIPI
GeneCards CDKN2B
UniProt P42772, K7PPU3
Vega OTTHUMG00000019691
MIM 600431
Ensembl ENSG00000147883
HGNC 1788
HPRD 02696

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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