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Sequence in raw or FASTA format:

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CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_004936 Homo sapiens cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) (CDKN2B), transcript variant 1, mRNA. ORF Sequence $159.00
Peptide Services
Antibody Services
Protein Services
NM_078487 Homo sapiens cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) (CDKN2B), transcript variant 2, mRNA. ORF Sequence $159.00
Peptide Services
Antibody Services
Protein Services


Gene Symbol CDKN2B
Entrez Gene ID 1030
Full Name cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
Synonyms CDK4I, INK4B, MTS2, P15, TP15, p15INK4b
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

9

9p21

Summary This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008].
Disorder

MIM: 600431

mRNA Protein Product Sequence Price Select
NM_004936, 47132608 NP_004927, 17981694 cyclin-dependent kinase 4 inhibitor B isoform 1 Full Length $1357.30
ORF Sequence $159.00
NM_078487, 47132609 NP_511042, 17981696 cyclin-dependent kinase 4 inhibitor B isoform 2 Full Length $1400.35
ORF Sequence $159.00
KEGG
hsa05222Small cell lung cancer
hsa05203Viral carcinogenesis
hsa05166HTLV-I infection
hsa05200Pathways in cancer
hsa04350TGF-beta signaling pathway
hsa04110Cell cycle
Pathway Interaction Database
myc_represspathwayValidated targets of C-MYC transcriptional repression
smad2_3nuclearpathwayRegulation of nuclear SMAD2/3 signaling
WikiPathways
WP2261Signaling Pathways in Glioblastoma
WP45G1 to S cell cycle control
WP2256Integrated Pancreatic Cancer Pathway
WP2377Integrated Pancreatic Cancer Pathway
Reactome
REACT_821Cyclin D associated events in G1
REACT_120734SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
REACT_71Gene Expression
REACT_6844Signaling by TGF-beta Receptor Complex
REACT_121061Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
REACT_115566Cell Cycle
REACT_12627Generic Transcription Pathway
REACT_111102Signal Transduction
REACT_152Cell Cycle, Mitotic
REACT_1590G1 Phase
REACT_21267Mitotic G1-G1/S phases
Homo sapiens (human)CDKN2BNP_004927.2
Pan troglodytes (chimpanzee)CDKN2BXP_003312069.1
Macaca mulatta (Rhesus monkey)CDKN2BXP_001107263.1
Canis lupus familiaris (dog)CDKN2BNP_001139741.1
Bos taurus (cattle)CDKN2BNP_001069362.1
Mus musculus (house mouse)Cdkn2bNP_031696.1
Rattus norvegicus (Norway rat)Cdkn2bNP_570825.1
Gallus gallus (chicken)CDKN2BNP_989764.1
GeneCards CDKN2B
UniProt P42772, K7PPU3
MIM 600431
Ensembl ENSG00000147883
HGNC 1788
HPRD 02696

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
cyclin-dependent kinase 4 inhibitor B
Names
cyclin-dependent kinase 4 inhibitor B
MTS-2
p14-INK4b
p14_INK4B
p15-INK4b
p15_INK4B
CDK4B inhibitor
p14_CDK inhibitor
p15 CDK inhibitor
CDK inhibitory protein
multiple tumor suppressor 2
cyclin-dependent kinases 4 and 6 binding protein

Interactant

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