• THAT   AND
  • THAT   AND


Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


SLC9A6 solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001042537 Homo sapiens solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6 (SLC9A6), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand TBD TBD
NM_001177651 Homo sapiens solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6 (SLC9A6), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_006359 Homo sapiens solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6 (SLC9A6), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand TBD TBD
XM_006724726 PREDICTED: Homo sapiens solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6 (SLC9A6), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $849.00 20

*Business Day

Related Services

Gene Symbol SLC9A6
Entrez Gene ID 10479
Full Name solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6
Synonyms MRSA, NHE6
General protein information
Preferred Names
sodium/hydrogen exchanger 6
Names
sodium/hydrogen exchanger 6
Na(+)/H(+) exchanger 6
solute carrier family 9 (sodium/hydrogen exchanger), member 6
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

X

Xq26.3

Summary This gene encodes a sodium-hydrogen exchanger that is amember of the solute carrier family 9. The encoded protein localizes to early and recycling endosomes and may be involved in regulating endosomal pH and volume. Defects in this gene are associated with X-linked syndromic mental retardation, Christianson type. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010].
Disorder

MIM: 300231

Mental retardation, X-linked syndromic, Christianson type, 300243 (3)

mRNA Protein Product Sequence Price Select
NM_001042537, 110227625 NP_001036002, 110227626 sodium/hydrogen exchanger 6 isoform a precursor ORF Sequence $700.00
NM_001177651, 294997329 NP_001171122, 294997330 sodium/hydrogen exchanger 6 isoform c ORF Sequence $700.00
NM_006359, 110227627 NP_006350, 5454070 sodium/hydrogen exchanger 6 isoform b precursor ORF Sequence $700.00
XM_006724726, 578838600 XP_006724789, 578838601 sodium/hydrogen exchanger 6 isoform X1 ORF Sequence $700.00
KEGG
hsa04260Cardiac muscle contraction
Reactome
REACT_19118SLC-mediated transmembrane transport
REACT_19314Sodium/Proton exchangers
REACT_19397Transport of inorganic cations/anions and amino acids/oligopeptides
REACT_15518Transmembrane transport of small molecules
Homo sapiens (human)SLC9A6NP_001036002.1
Pan troglodytes (chimpanzee)SLC9A6XP_529172.3
Macaca mulatta (Rhesus monkey)SLC9A6XP_001101721.1
Canis lupus familiaris (dog)SLC9A6XP_538181.4
Bos taurus (cattle)SLC9A6NP_001094616.1
Mus musculus (house mouse)Slc9a6NP_766368.2
Rattus norvegicus (Norway rat)Slc9a6XP_217630.3
Gallus gallus (chicken)SLC9A6XP_420229.3
Danio rerio (zebrafish)slc9a6aNP_001091726.2
Drosophila melanogaster (fruit fly)Nhe3NP_723202.2
Caenorhabditis elegansnhx-5NP_001024721.1
Xenopus (Silurana) tropicalis (western clawed frog)slc9a6XP_002932638.2
Process
IDNameEvidence
GO:0006810transportTAS
GO:0006811ion transportTAS
GO:0006885regulation of pHIEA
GO:0035725sodium ion transmembrane transportIEA
GO:0035725sodium ion transmembrane transportTAS
GO:0048675axon extensionIDA
GO:0048812neuron projection morphogenesisIDA
GO:0055085transmembrane transportTAS
GO:0097484dendrite extensionIDA
GO:1902600hydrogen ion transmembrane transportIEA
Component
IDNameEvidence
GO:0005739mitochondrionIDA
GO:0005789endoplasmic reticulum membraneIDA
GO:0005886plasma membraneIDA
GO:0016021integral component of membraneIEA
GO:0031901early endosome membraneIDA
GO:0031901early endosome membraneTAS
GO:0055038recycling endosome membraneIDA
Function
IDNameEvidence
GO:0015385sodium:proton antiporter activityIEA
GeneCards SLC9A6
UniProt Q92581
Vega OTTHUMG00000022498
MIM 300231
Ensembl ENSG00000198689
HGNC 11079
HPRD 02208

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the SLC9A6 gene?

The SLC9A6 gene provides instructions for making a protein called sodium/hydrogen exchanger 6 (Na+/H+ exchanger 6 or NHE6). Na+/H+ exchangers are found in the membranes that surround cells or compartments within cells. These proteins act as channels that allow positively charged sodium atoms (Na+ ions) into the cell or cellular compartment in exchange for positively charged hydrogen ions (H+, also known as protons), which are removed. The exchange of hydrogen ions helps regulate the relative acidity (pH) of the cell or cellular compartment.

The NHE6 protein is found in the membrane of compartments within the cell known as endosomes, which recycle proteins and other cellular materials. The NHE6 protein controls the pH inside endosomes, which is important for the recycling function of these compartments. The NHE6 protein may have additional functions, such as helping to move proteins to the correct location in the cell (protein trafficking).

Interactant

Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.