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SLC9A6 solute carrier family 9 (sodium/hydrogen exchanger), member 6 [Homo sapiens (human)]


RefSeq Accession Definition Sequence Price Select
NM_001042537 Homo sapiens solute carrier family 9 (sodium/hydrogen exchanger), member 6 (SLC9A6), transcript variant 1, mRNA. Full Length $1659.70
ORF Sequence $610.74
NM_006359 Homo sapiens solute carrier family 9 (sodium/hydrogen exchanger), member 6 (SLC9A6), transcript variant 2, mRNA. Full Length $1626.10
ORF Sequence $582.90
NM_001177651 Homo sapiens solute carrier family 9 (sodium/hydrogen exchanger), member 6 (SLC9A6), transcript variant 3, mRNA. Full Length $1617.00
ORF Sequence $565.50


Gene Symbol SLC9A6
Entrez Gene ID 10479
Full Name solute carrier family 9 (sodium/hydrogen exchanger), member 6
Synonyms KIAA0267, MRSA, NHE6
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

X

Xq26.3
Summary This gene encodes a sodium-hydrogen exchanger that is amember of the solute carrier family 9. The encoded protein localizes to early and recycling endosomes and may be involved in regulating endosomal pH and volume. Defects in this gene are associated with X-linked syndromic mental retardation, Christianson type. Alternate splicing results in multiple transcript variants.
Disorder

MIM: 300231

Mental retardation, X-linked syndromic, Christianson type, 300243 (3)
mRNA NM_001042537, 110227625
Protein NP_001036002, 110227626
Product sodium/hydrogen exchanger 6 isoform a precursor
RefSeq Status REVIEWED
mRNA NM_006359, 110227627
Protein NP_006350, 5454070
Product sodium/hydrogen exchanger 6 isoform b precursor
RefSeq Status REVIEWED
mRNA NM_001177651, 294997329
Protein NP_001171122, 294997330
Product sodium/hydrogen exchanger 6 isoform c
RefSeq Status REVIEWED
KEGG
hsa04260Cardiac muscle contraction
Reactome
REACT_19314Sodium/Proton exchangers
REACT_19397Transport of inorganic cations/anions and amino acids/oligopeptides
REACT_19118SLC-mediated transmembrane transport
REACT_15518Transmembrane transport of small molecules
Homo sapiens (human)SLC9A6NP_001036002.1
Pan troglodytes (chimpanzee)SLC9A6XP_529172.2
Canis lupus familiaris (dog)SLC9A6XP_538181.2
Bos taurus (cattle)SLC9A6NP_001094616.1
Mus musculus (house mouse)Slc9a6NP_766368.1
Rattus norvegicus (Norway rat)Slc9a6XP_217630.3
Gallus gallus (chicken)SLC9A6XP_420229.1
Danio rerio (zebrafish)slc9a6aNP_001091726.2
Process
IDNameEvidence
GO:0006810transportTAS
GO:0006811ion transportTAS
GO:0006812cation transportIEA
GO:0006814sodium ion transportIEA
GO:0006885regulation of pHIEA
GO:0055085transmembrane transportTAS
Component
IDNameEvidence
GO:0005739mitochondrionIDA
GO:0005768endosomeIEA
GO:0005789endoplasmic reticulum membraneIDA
GO:0005792microsomeIDA
GO:0005886plasma membraneIDA
GO:0016021integral to membraneIEA
GO:0031901early endosome membraneIDA
GO:0031901early endosome membraneTAS
GO:0055038recycling endosome membraneIDA
Function
IDNameEvidence
GO:0015297antiporter activityIEA
GO:0015299solute:hydrogen antiporter activityIEA
GO:0015385sodium:hydrogen antiporter activityTAS
GeneCards SLC9A6
UniProt B4DU30, Q86VS0, Q3ZCW7, Q5JPP8, Q92581
MIM 300231
Ensembl ENSG00000198689
HGNC 11079
HPRD 02208

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