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HOXB13 homeobox B13 [Homo sapiens (human)]


RefSeq Accession Definition Sequence Price Select
NM_006361 Homo sapiens homeobox B13 (HOXB13), mRNA. Full Length $1066.45
ORF Sequence $247.95


Gene Symbol HOXB13
Entrez Gene ID 10481
Full Name homeobox B13
Synonyms PSGD
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

17

17q21.2
Summary This gene encodes a transcription factor that belongs to the homeobox gene family. Genes of this family are highly conserved among vertebrates and essential for vertebrate embryonic development. This gene has been implicated to play a role in fetal skin development and cutaneous regeneration. In mice, a similar gene was shown to exhibit temporal and spatial colinearity in the main body axis of the embryo, but was not expressed in the secondary axes, which suggests functions in body patterning along the axis. This gene and other HOXB genes form a gene cluster at chromosome the 17q21-22 region. [provided by RefSeq].
Disorder

MIM: 604607
mRNA NM_006361, 84043952
Protein NP_006352, 62865866
Product homeobox protein Hox-B13
RefSeq Status REVIEWED
Pathway Interaction Database
ar_tf_pathwayRegulation of Androgen receptor activity
Homo sapiens (human)HOXB13NP_006352.2
Pan troglodytes (chimpanzee)HOXB13XP_523822.1
Canis lupus familiaris (dog)HOXB13XP_548180.2
Mus musculus (house mouse)Hoxb13NP_032293.1
Rattus norvegicus (Norway rat)Hoxb13XP_220905.3
Gallus gallus (chicken)HOXB13XP_001234927.1
Danio rerio (zebrafish)hoxb13aNP_001038377.1
Process
IDNameEvidence
GO:0001525angiogenesisIEP
GO:0002009morphogenesis of an epitheliumIEA
GO:0006355regulation of transcription, DNA-dependentIEA
GO:0007275multicellular organismal developmentIEA
GO:0008544epidermis developmentTAS
GO:0009611response to woundingTAS
GO:0040008regulation of growthIEA
GO:0060527prostate epithelial cord arborization involved in prostate glandular acinus morphogenesisIEA
GO:0060743epithelial cell maturation involved in prostate gland developmentIEA
Component
IDNameEvidence
GO:0005634nucleusIEA
GO:0005667transcription factor complexIEA
Function
IDNameEvidence
GO:0003700sequence-specific DNA binding transcription factor activityIEA
GO:0043565sequence-specific DNA bindingIEA
GeneCards HOXB13
PDB 2CRA
UniProt Q4KR72, Q92826
MIM 604607
Ensembl ENSG00000159184
HGNC 5112
HPRD 05210

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