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CEBPA CCAAT/enhancer binding protein (C/EBP), alpha [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_004364 Homo sapiens CCAAT/enhancer binding protein (C/EBP), alpha (CEBPA), mRNA. ORF Sequence $312.33
Peptide Services
Antibody Services
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Gene Symbol CEBPA
Entrez Gene ID 1050
Full Name CCAAT/enhancer binding protein (C/EBP), alpha
Synonyms C/EBP-alpha, CEBP
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

19

19q13.1

Summary The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain promoters and enhancers. It can also form heterodimers with the related proteins CEBP-beta and CEBP-gamma. The encoded protein has been shown to bind to the promoter and modulate the expression of the gene encoding leptin, a protein that plays an important role in body weight homeostasis. Also, the encoded protein can interact with CDK2 and CDK4, thereby inhibiting these kinases and causing growth arrest in cultured cells. [provided by RefSeq, Jul 2008].
Disorder

MIM: 116897

Leukemia, acute myeloid, 601626 (3)

mRNA Protein Product Sequence Price Select
NM_004364, 225735576 NP_004355, 28872794 CCAAT/enhancer-binding protein alpha Full Length $751.39
ORF Sequence $312.33
KEGG
hsa05200Pathways in cancer
hsa05202Transcriptional misregulation in cancer
hsa05221Acute myeloid leukemia
WikiPathways
WP236Adipogenesis
WP437EGFR1 Signaling Pathway
Pathway Interaction Database
cmyb_pathwayC-MYB transcription factor network
hnf3bpathwayFOXA2 and FOXA3 transcription factor networks
myc_represspathwayValidated targets of C-MYC transcriptional repression
rb_1pathwayRegulation of retinoblastoma protein
ar_tf_pathwayRegulation of Androgen receptor activity
e2f_pathwayE2F transcription factor network
Reactome
REACT_111045Developmental Biology
REACT_27161Transcriptional Regulation of White Adipocyte Differentiation
Homo sapiens (human)CEBPANP_004355.2
Bos taurus (cattle)CEBPANP_789741.2
Mus musculus (house mouse)CebpaNP_031704.2
Rattus norvegicus (Norway rat)CebpaNP_036656.1
Gallus gallus (chicken)CEBPANP_001026630.1
Danio rerio (zebrafish)cebpaNP_571960.1
GeneCards CEBPA
UniProt P49715
MIM 116897
Ensembl ENSG00000245848
HGNC 1833
HPRD 00296

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
CCAAT/enhancer-binding protein alpha
Names
CCAAT/enhancer-binding protein alpha

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