CEBPA CCAAT/enhancer binding protein (C/EBP), alpha [Homo sapiens (human)]

Gene Symbol	CEBPA
Entrez Gene ID	1050
Full Name	CCAAT/enhancer binding protein (C/EBP), alpha
Synonyms	C/EBP-alpha, CEBP
Gene Type	protein-coding
Organism	Homo sapiens (human)
Genome	Chromosome:19 Map Location:19q13.1
Summary	The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain promoters and enhancers. It can also form heterodimers with the related proteins CEBP-beta and CEBP-gamma. The encoded protein has been shown to bind to the promoter and modulate the expression of the gene encoding leptin, a protein that plays an important role in body weight homeostasis. Also, the encoded protein can interact with CDK2 and CDK4, thereby inhibiting these kinases and causing growth arrest in cultured cells. [provided by RefSeq].
Disorder	MIM: 116897 Leukemia, acute myeloid, 601626 (3)

mRNA	NM_004364, 225735576
Protein	NP_004355, 28872794
Product	CCAAT/enhancer-binding protein alpha
RefSeq Status	REVIEWED

KEGG

hsa05200	Pathways in cancer
hsa05221	Acute myeloid leukemia

WikiPathways

WP236	Adipogenesis
WP437	EGFR1 Signaling Pathway

Pathway Interaction Database

hnf3bpathway	FOXA2 and FOXA3 transcription factor networks
myc_represspathway	Validated targets of C-MYC transcriptional repression
rb_1pathway	Regulation of retinoblastoma protein
ar_tf_pathway	Regulation of Androgen receptor activity
e2f_pathway	E2F transcription factor network
cmyb_pathway	C-MYB transcription factor network

Homo sapiens (human)	CEBPA	NP_004355.2
Bos taurus (cattle)	CEBPA	NP_789741.2
Mus musculus (house mouse)	Cebpa	NP_031704.2
Rattus norvegicus (Norway rat)	Cebpa	NP_036656.1
Gallus gallus (chicken)	CEBPA	NP_001026630.1
Danio rerio (zebrafish)	cebpa	NP_571960.1

Process

ID	Name	Evidence
GO:0000050	urea cycle	IEA
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IEA
GO:0001889	liver development	IEA
GO:0001892	embryonic placenta development	IEA
GO:0006091	generation of precursor metabolites and energy	TAS
GO:0006351	transcription, DNA-dependent	IDA
GO:0006351	transcription, DNA-dependent	NAS
GO:0006355	regulation of transcription, DNA-dependent	IEA
GO:0006366	transcription from RNA polymerase II promoter	TAS
GO:0006953	acute-phase response	IEA
GO:0007005	mitochondrion organization	IEA
GO:0007584	response to nutrient	IEA
GO:0008203	cholesterol metabolic process	IEA
GO:0008285	negative regulation of cell proliferation	IEA
GO:0019221	cytokine-mediated signaling pathway	NAS
GO:0030099	myeloid cell differentiation	NAS
GO:0030225	macrophage differentiation	IEA
GO:0030324	lung development	IEA
GO:0031100	organ regeneration	IEA
GO:0033274	response to vitamin B2	IEA
GO:0044419	interspecies interaction between organisms	IEA
GO:0045600	positive regulation of fat cell differentiation	IEA
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IEA
GO:0045945	positive regulation of transcription from RNA polymerase III promoter	IDA
GO:0048469	cell maturation	IEA
GO:0050872	white fat cell differentiation	IEA
GO:0050873	brown fat cell differentiation	IEA
GO:0051384	response to glucocorticoid stimulus	IEA
GO:0071285	cellular response to lithium ion	IEA
GO:0071407	cellular response to organic cyclic compound	IEA

Component

Function

ID	Name	Evidence
GO:0003677	DNA binding	TAS
GO:0003700	sequence-specific DNA binding transcription factor activity	IDA
GO:0003705	sequence-specific enhancer binding RNA polymerase II transcription factor activity	NAS
GO:0005515	protein binding	IPI
GO:0008134	transcription factor binding	IPI
GO:0019904	protein domain specific binding	IEA
GO:0032403	protein complex binding	IEA
GO:0042803	protein homodimerization activity	IEA
GO:0043565	sequence-specific DNA binding	IEA
GO:0046982	protein heterodimerization activity	IEA

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RefSeq Accession	Definition	Sequence	Price	Select
NM_004364	Homo sapiens CCAAT/enhancer binding protein (C/EBP), alpha (CEBPA), mRNA.	Full Length	$751.39
NM_004364		ORF Sequence	$312.33