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CEBPA CCAAT/enhancer binding protein (C/EBP), alpha [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001285829 Homo sapiens CCAAT/enhancer binding protein (C/EBP), alpha (CEBPA), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand TBD TBD
NM_001287424 Homo sapiens CCAAT/enhancer binding protein (C/EBP), alpha (CEBPA), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand TBD TBD
NM_001287435 Homo sapiens CCAAT/enhancer binding protein (C/EBP), alpha (CEBPA), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand TBD TBD
NM_004364 Homo sapiens CCAAT/enhancer binding protein (C/EBP), alpha (CEBPA), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand TBD TBD

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Gene Symbol CEBPA
Entrez Gene ID 1050
Full Name CCAAT/enhancer binding protein (C/EBP), alpha
Synonyms C/EBP-alpha, CEBP
General protein information
Preferred Names
CCAAT/enhancer-binding protein alpha
CCAAT/enhancer-binding protein alpha
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. Mutation of this gene is associated with acute myeloid leukemia. The use of alternative in-frame non-AUG (GUG) and AUG start codons results in protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the GUG and the first AUG start codons. [provided by RefSeq, Dec 2013].

MIM: 116897

Leukemia, acute myeloid, 601626 (3)

mRNA Protein Product Sequence Price Select
NM_001285829, 551894997 NP_001272758, 551894998 CCAAT/enhancer-binding protein alpha isoform b ORF Sequence $250.00
NM_001287424, 566559991 NP_001274353, 566559992 CCAAT/enhancer-binding protein alpha isoform c ORF Sequence $400.00
NM_001287435, 566559993 NP_001274364, 566559994 CCAAT/enhancer-binding protein alpha isoform d ORF Sequence $400.00
NM_004364, 551894987 NP_004355, 28872794 CCAAT/enhancer-binding protein alpha isoform a ORF Sequence $400.00
hsa05221Acute myeloid leukemia
hsa05200Pathways in cancer
hsa05202Transcriptional misregulation in cancer
hsa04932Non-alcoholic fatty liver disease (NAFLD)
WP437EGFR1 Signaling Pathway
Pathway Interaction Database
hnf3bpathwayFOXA2 and FOXA3 transcription factor networks
rb_1pathwayRegulation of retinoblastoma protein
e2f_pathwayE2F transcription factor network
cmyb_pathwayC-MYB transcription factor network
ar_tf_pathwayRegulation of Androgen receptor activity
myc_represspathwayValidated targets of C-MYC transcriptional repression
REACT_27161Transcriptional regulation of white adipocyte differentiation
REACT_111045Developmental Biology
Homo sapiens (human)CEBPANP_001274353.1
Pan troglodytes (chimpanzee)CEBPAXP_001154519.2
Macaca mulatta (Rhesus monkey)LOC717153XP_001108401.1
Bos taurus (cattle)CEBPANP_789741.2
Mus musculus (house mouse)CebpaNP_031704.2
Rattus norvegicus (Norway rat)CebpaNP_036656.1
Gallus gallus (chicken)CEBPANP_001026630.1
Danio rerio (zebrafish)cebpaNP_571960.1
Xenopus (Silurana) tropicalis (western clawed frog)cebpaNP_001011044.1
GO:0000050urea cycleIEA
GO:0000122negative regulation of transcription from RNA polymerase II promoterIEA
GO:0001889liver developmentIEA
GO:0001892embryonic placenta developmentIEA
GO:0006091generation of precursor metabolites and energyTAS
GO:0006351transcription, DNA-templatedIDA
GO:0006351transcription, DNA-templatedNAS
GO:0006366transcription from RNA polymerase II promoterTAS
GO:0006953acute-phase responseIEA
GO:0007005mitochondrion organizationIEA
GO:0008203cholesterol metabolic processIEA
GO:0008285negative regulation of cell proliferationIEA
GO:0016032viral processIEA
GO:0019221cytokine-mediated signaling pathwayNAS
GO:0030099myeloid cell differentiationNAS
GO:0030225macrophage differentiationIEA
GO:0030324lung developmentIEA
GO:0031100organ regenerationIEA
GO:0033274response to vitamin B2IEA
GO:0045600positive regulation of fat cell differentiationIEA
GO:0045669positive regulation of osteoblast differentiationIEA
GO:0045944positive regulation of transcription from RNA polymerase II promoterIEA
GO:0045945positive regulation of transcription from RNA polymerase III promoterIDA
GO:0048469cell maturationIEA
GO:0048839inner ear developmentIEA
GO:0050872white fat cell differentiationIEA
GO:0050873brown fat cell differentiationIEA
GO:0051384response to glucocorticoidIEA
GO:0071285cellular response to lithium ionIEA
GO:0071407cellular response to organic cyclic compoundIEA
GO:0016363nuclear matrixIEA
GO:0035189Rb-E2F complexIEA
GO:0003677DNA bindingTAS
GO:0003700sequence-specific DNA binding transcription factor activityIDA
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityNAS
GO:0005515protein bindingIPI
GO:0008134transcription factor bindingIPI
GO:0032403protein complex bindingIEA
GO:0042803protein homodimerization activityIEA
GO:0043565sequence-specific DNA bindingIEA
GO:0044212transcription regulatory region DNA bindingIDA
GO:0046982protein heterodimerization activityIEA
GO:0071837HMG box domain bindingIEA
GeneCards CEBPA
UniProt P49715
Vega OTTHUMG00000161461
MIM 116897
Ensembl ENSG00000245848
HGNC 1833
HPRD 00296

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the CEBPA gene?

The CEBPA gene provides instructions for making a protein called CCAAT/enhancer-binding protein alpha. This protein is a transcription factor, which means that it attaches (binds) to specific regions of DNA and helps control the activity (expression) of certain genes. CCAAT/enhancer-binding protein alpha is involved in the maturation (differentiation) of certain blood cells. It is also believed to act as a tumor suppressor, which means that it is involved in cellular mechanisms that help prevent the cells from growing and dividing too rapidly or in an uncontrolled way.


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