CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon [Homo sapiens (human)]
| Gene Symbol | CEBPE |
| Entrez Gene ID | 1053 |
| Full Name | CCAAT/enhancer binding protein (C/EBP), epsilon |
| Synonyms | C/EBP-epsilon, CRP1 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
14 14q11.2 |
| Summary | The protein encoded by this gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-delta. The encoded protein may be essential for terminal differentiation and functional maturation of committed granulocyte progenitor cells. Mutations in this gene have been associated with Specific Granule Deficiency, a rare congenital disorder. Multiple variants of this gene have been described, but the full-length nature of only one has been determined. [provided by RefSeq]. |
| Disorder | MIM: 600749 Specific granule deficiency, 245480 (3) |
| mRNA | NM_001805, 28872799 |
| Protein | NP_001796, 28872800 |
| Product | CCAAT/enhancer-binding protein epsilon |
| RefSeq Status | REVIEWED |
| Homo sapiens (human) | CEBPE | NP_001796.2 |
| Pan troglodytes (chimpanzee) | CEBPE | XP_001161080.1 |
| Canis lupus familiaris (dog) | CEBPE | XP_547729.1 |
| Bos taurus (cattle) | CEBPE | XP_614092.1 |
| Mus musculus (house mouse) | Cebpe | NP_997014.1 |
| Rattus norvegicus (Norway rat) | Cebpe | NP_058791.1 |
| ID | Name | Evidence |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA |
| GO:0006909 | phagocytosis | IEA |
| GO:0006952 | defense response | TAS |
| GO:0030099 | myeloid cell differentiation | IEA |
| GO:0030225 | macrophage differentiation | IEA |
| GO:0042089 | cytokine biosynthetic process | IEA |
| GO:0042742 | defense response to bacterium | IEA |
Component
| ID | Name | Evidence |
| GO:0005634 | nucleus | IDA |
| GO:0005730 | nucleolus | IDA |
Function
| ID | Name | Evidence |
| GO:0003700 | sequence-specific DNA binding transcription factor activity | IEA |
| GO:0042803 | protein homodimerization activity | IEA |
| GO:0043565 | sequence-specific DNA binding | IEA |
| GO:0046982 | protein heterodimerization activity | IEA |
Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.
 |
Secured Online Quotation |
 |
Email: gene@genscript.com |
 |
Phone: 1-877-436-7274 (Toll-Free) 1-732-885-9188 |
 |
Fax: 1-732-210-0262 1-732-885-5878 |