AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta) [Homo sapiens (human)]
| Gene Symbol | AGPAT2 |
| Entrez Gene ID | 10555 |
| Full Name | 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta) |
| Synonyms | 1-AGPAT2, BSCL, BSCL1, LPAAB, LPAAT-beta |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
9 9q34.3 |
| Summary | This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. The protein is located within the endoplasmic reticulum membrane and converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. Mutations in this gene have been associated with congenital generalized lipodystrophy (CGL), or Berardinelli-Seip syndrome, a disease characterized by a near absence of adipose tissue and severe insulin resistance. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq]. |
| Disorder | MIM: 603100 Lipodystrophy, congenital generalized, type 1, 608594 (3) |
| mRNA | NM_006412, 68835055 |
| Protein | NP_006403, 6041665 |
| Product | 1-acyl-sn-glycerol-3-phosphate acyltransferase beta isoform a |
| RefSeq Status | REVIEWED |
| mRNA | NM_001012727, 69122970 |
| Protein | NP_001012745, 69122971 |
| Product | 1-acyl-sn-glycerol-3-phosphate acyltransferase beta isoform b |
| RefSeq Status | REVIEWED |
| hsa00561 | Glycerolipid metabolism |
| hsa00564 | Glycerophospholipid metabolism |
| hsa01100 | Metabolic pathways |
| hsa04975 | Fat digestion and absorption |
WikiPathways
| WP325 | Triacylglyceride Synthesis |
| WP236 | Adipogenesis |
Reactome
| REACT_1190 | Triglyceride Biosynthesis |
| REACT_22258 | Metabolism of lipids and lipoproteins |
| REACT_22279 | Fatty acid, triacylglycerol, and ketone body metabolism |
| Homo sapiens (human) | AGPAT2 | NP_006403.2 |
| Pan troglodytes (chimpanzee) | AGPAT2 | XP_001162511.1 |
| Canis lupus familiaris (dog) | AGPAT2 | XP_548370.2 |
| Bos taurus (cattle) | AGPAT2 | NP_001073733.1 |
| Mus musculus (house mouse) | Agpat2 | NP_080488.1 |
| Rattus norvegicus (Norway rat) | Agpat2 | XP_231089.4 |
| Gallus gallus (chicken) | AGPAT2 | XP_001235300.1 |
| ID | Name | Evidence |
| GO:0001819 | positive regulation of cytokine production | IMP |
| GO:0001961 | positive regulation of cytokine-mediated signaling pathway | IC |
| GO:0006644 | phospholipid metabolic process | NAS |
| GO:0006654 | phosphatidic acid biosynthetic process | IGI |
| GO:0008152 | metabolic process | IEA |
| GO:0008654 | phospholipid biosynthetic process | IEA |
| GO:0019432 | triglyceride biosynthetic process | EXP |
| GO:0044255 | cellular lipid metabolic process | TAS |
Component
| ID | Name | Evidence |
| GO:0005783 | endoplasmic reticulum | ISS |
| GO:0005789 | endoplasmic reticulum membrane | TAS |
| GO:0016020 | membrane | IEA |
| GO:0016021 | integral to membrane | IEA |
Function
| ID | Name | Evidence |
| GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity | IGI |
| GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity | NAS |
| GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity | TAS |
| GO:0008415 | acyltransferase activity | IEA |
| GO:0016740 | transferase activity | IEA |
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