• THAT   AND

Sequence in raw or FASTA format:


Blast Method:


AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001012727 Homo sapiens 1-acylglycerol-3-phosphate O-acyltransferase 2 (AGPAT2), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $399.00 14
NM_006412 Homo sapiens 1-acylglycerol-3-phosphate O-acyltransferase 2 (AGPAT2), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $449.00 14

*Business Day

Related Services

Gene Symbol AGPAT2
Entrez Gene ID 10555
Full Name 1-acylglycerol-3-phosphate O-acyltransferase 2
Synonyms 1-AGPAT2, BSCL, BSCL1, LPAAB, LPAAT-beta
General protein information
Preferred Names
1-acyl-sn-glycerol-3-phosphate acyltransferase beta
1-acyl-sn-glycerol-3-phosphate acyltransferase beta
1-AGP acyltransferase 2
lysophosphatidic acid acyltransferase beta
lysophosphatidic acid acyltransferase-beta
1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. The protein is located within the endoplasmic reticulum membrane and converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. Mutations in this gene have been associated with congenital generalized lipodystrophy (CGL), or Berardinelli-Seip syndrome, a disease characterized by a near absence of adipose tissue and severe insulin resistance. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].

MIM: 603100

Lipodystrophy, congenital generalized, type 1, 608594 (3)

mRNA Protein Product Sequence Price Select
NM_001012727, 69122970 NP_001012745, 69122971 1-acyl-sn-glycerol-3-phosphate acyltransferase beta isoform b precursor ORF Sequence $250.00
NM_006412, 68835055 NP_006403, 6041665 1-acyl-sn-glycerol-3-phosphate acyltransferase beta isoform a precursor ORF Sequence $300.00
hsa00561Glycerolipid metabolism
hsa00564Glycerophospholipid metabolism
hsa04975Fat digestion and absorption
hsa_M00089Triacylglycerol biosynthesis
WP325Triacylglyceride Synthesis
WP2377Integrated Pancreatic Cancer Pathway
HUMAN_PWY-5667CDP-diacylglycerol biosynthesis I
HUMAN_TRIGLSYN-PWYtriacylglycerol biosynthesis
HUMAN_PWY4FS-8phosphatidylglycerol biosynthesis II (non-plastidic)
REACT_1190Triglyceride Biosynthesis
REACT_22279Fatty acid, triacylglycerol, and ketone body metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_121401Glycerophospholipid biosynthesis
REACT_120870Phospholipid metabolism
REACT_120906Synthesis of PA
Homo sapiens (human)AGPAT2NP_006403.2
Pan troglodytes (chimpanzee)AGPAT2XP_001162511.3
Macaca mulatta (Rhesus monkey)AGPAT2XP_001094500.1
Canis lupus familiaris (dog)AGPAT2XP_548370.4
Bos taurus (cattle)AGPAT2NP_001073733.1
Mus musculus (house mouse)Agpat2NP_080488.1
Rattus norvegicus (Norway rat)Agpat2NP_001101291.1
Gallus gallus (chicken)AGPAT2XP_001235300.2
Xenopus (Silurana) tropicalis (western clawed frog)agpat2NP_001123741.1
GO:0001819positive regulation of cytokine productionIMP
GO:0001961positive regulation of cytokine-mediated signaling pathwayIC
GO:0006644phospholipid metabolic processNAS
GO:0006644phospholipid metabolic processTAS
GO:0006654phosphatidic acid biosynthetic processIGI
GO:0006654phosphatidic acid biosynthetic processTAS
GO:0008544epidermis developmentIEA
GO:0016024CDP-diacylglycerol biosynthetic processIEA
GO:0019432triglyceride biosynthetic processTAS
GO:0044255cellular lipid metabolic processTAS
GO:0044281small molecule metabolic processTAS
GO:0046474glycerophospholipid biosynthetic processTAS
GO:0005783endoplasmic reticulumISS
GO:0005789endoplasmic reticulum membraneTAS
GO:0016021integral component of membraneIEA
GO:00038411-acylglycerol-3-phosphate O-acyltransferase activityIGI
GO:00038411-acylglycerol-3-phosphate O-acyltransferase activityNAS
GeneCards AGPAT2
UniProt O15120
Vega OTTHUMG00000020936
MIM 603100
Ensembl ENSG00000169692
HGNC 325
HPRD 04373

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the AGPAT2 gene?

The AGPAT2 gene provides instructions for making an enzyme that plays a critical role in the growth and development of adipocytes, which are the body's fat-storing cells.

The AGPAT2 enzyme is part of a chemical pathway that produces two important types of fats (lipids): glycerophospholipids and triacylglycerols. Glycerophospholipids are the major component of cell membranes throughout the body; they are also involved in chemical signaling within cells. Triacylglycerols (also known as triglycerides) are molecules in adipocytes that store fats for later conversion to energy.

The AGPAT2 enzyme is responsible for a particular chemical reaction in the production of these two types of lipids. Specifically, the enzyme helps convert a molecule called lysophosphatidic acid (LPA) to another molecule, phosphatidic acid (PA). Additional reactions convert phosphatidic acid to glycerophospholipids and triacylglycerols.


Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.