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SLCO1B1 solute carrier organic anion transporter family, member 1B1 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_006446 Homo sapiens solute carrier organic anion transporter family, member 1B1 (SLCO1B1), mRNA. GenEZ ORF Cloning In-stock $639.00 $590.00 15

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Gene Symbol SLCO1B1
Entrez Gene ID 10599
Full Name solute carrier organic anion transporter family, member 1B1
Synonyms HBLRR, LST-1, LST1, OATP-C, OATP1B1, OATP2, OATPC, SLC21A6
General protein information
Preferred Names
solute carrier organic anion transporter family member 1B1
Names
solute carrier organic anion transporter family member 1B1
OATP-2
solute carrier family 21 member 6
liver-specific organic anion transporter 1
sodium-independent organic anion-transporting polypeptide 2
solute carrier family 21 (organic anion transporter), member 6
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

12

12p

Summary This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including bilirubin, 17-beta-glucuronosyl estradiol and leukotriene C4. This protein is also involved in the removal of drug compounds such as statins, bromosulfophthalein and rifampin from the blood into the hepatocytes. Polymorphisms in the gene encoding this protein are associated with impaired transporter function. [provided by RefSeq, Mar 2009].
Disorder

MIM: 604843

mRNA Protein Product Sequence Price Select
NM_006446, 225543524 NP_006437, 225543525 solute carrier organic anion transporter family member 1B1 ORF Sequence $490.00
KEGG
hsa04976Bile secretion
WikiPathways
WP1604Codeine and morphine metabolism
WP2289Drug Induction of Bile Acid Pathway
Reactome
REACT_19118SLC-mediated transmembrane transport
REACT_11040Bile acid and bile salt metabolism
REACT_11042Recycling of bile acids and salts
REACT_15518Transmembrane transport of small molecules
REACT_22258Metabolism of lipids and lipoproteins
REACT_22285Transport of vitamins, nucleosides, and related molecules
REACT_23988Transport of organic anions
REACT_111217Metabolism
Homo sapiens (human)SLCO1B1NP_006437.3
Pan troglodytes (chimpanzee)SLCO1B1XP_520785.2
Macaca mulatta (Rhesus monkey)SLCO1B1XP_001097704.1
Gallus gallus (chicken)SLCO1B1XP_416418.3
Xenopus (Silurana) tropicalis (western clawed frog)slco1b3NP_001027493.1
Process
IDNameEvidence
GO:0008206bile acid metabolic processTAS
GO:0015711organic anion transportTAS
GO:0015721bile acid and bile salt transportTAS
GO:0043252sodium-independent organic anion transportTAS
GO:0044281small molecule metabolic processTAS
GO:0055085transmembrane transportTAS
Component
IDNameEvidence
GO:0005886plasma membraneTAS
GO:0005887integral component of plasma membraneTAS
GO:0016020membraneTAS
GO:0016323basolateral plasma membraneIEA
Function
IDNameEvidence
GO:0015347sodium-independent organic anion transmembrane transporter activityTAS
GeneCards SLCO1B1
UniProt Q05CV5, Q9Y6L6
Vega OTTHUMG00000169047
MIM 604843
Ensembl ENSG00000134538
HGNC 10959
HPRD 09214

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the SLCO1B1 gene?

The SLCO1B1 gene provides instructions for making a protein called organic anion transporting polypeptide 1B1, or OATP1B1. This protein is found in liver cells; it transports compounds from the blood into the liver so that they can be cleared from the body. For example, the OATP1B1 protein transports bilirubin, which is a yellowish substance that is produced when red blood cells are broken down. In the liver, bilirubin is dissolved in a digestive fluid called bile and then excreted from the body. The OATP1B1 protein also transports certain hormones, toxins, and drugs into the liver for removal from the body. Drugs transported by the OATP1B1 protein include statins, which are used to treat high cholesterol; heart disease medications; certain antibiotics; and some drugs used for the treatment of cancer.

Interactant

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