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TRAF3IP2 TRAF3 interacting protein 2 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001164281 Homo sapiens TRAF3 interacting protein 2 (TRAF3IP2), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_001164283 Homo sapiens TRAF3 interacting protein 2 (TRAF3IP2), transcript variant 5, mRNA. GenEZ ORF Cloning On-demand $299.00 14
NM_147686 Homo sapiens TRAF3 interacting protein 2 (TRAF3IP2), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_006715319 PREDICTED: Homo sapiens TRAF3 interacting protein 2 (TRAF3IP2), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $299.00 14

*Business Day

Related Services

Gene Symbol TRAF3IP2
Entrez Gene ID 10758
Full Name TRAF3 interacting protein 2
Synonyms ACT1, C6orf2, C6orf4, C6orf5, C6orf6, CANDF8, CIKS, PSORS13
General protein information
Preferred Names
adapter protein CIKS
Names
adapter protein CIKS
NFkB-activating protein ACT1
connection to IKK and SAPK/JNK
nuclear factor NF-kappa-B activator 1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

6

6q21

Summary This gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and stress. This gene product interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase. Several alternative transcripts encoding different isoforms have been identified. Another transcript, which does not encode a protein and is transcribed in the opposite orientation, has been identified. Overexpression of this transcript has been shown to reduce expression of at least one of the protein encoding transcripts, suggesting it has a regulatory role in the expression of this gene. [provided by RefSeq, Aug 2009].
Disorder

MIM: 607043

mRNA Protein Product Sequence Price Select
NM_001164281, 373938459 NP_001157753, 256017209 adapter protein CIKS isoform 3 ORF Sequence $550.00
NM_001164283, 373938460 NP_001157755, 256017213 adapter protein CIKS isoform 5 ORF Sequence $150.00
NM_147686, 373938458 NP_679211, 256017207 adapter protein CIKS isoform 2 ORF Sequence $550.00
XM_006715319, 578812350 XP_006715382, 578812351 adapter protein CIKS isoform X1 ORF Sequence $150.00
WikiPathways
WP2112IL17 signaling pathway
Homo sapiens (human)TRAF3IP2NP_679211.2
Pan troglodytes (chimpanzee)TRAF3IP2XP_003950952.1
Macaca mulatta (Rhesus monkey)TRAF3IP2XP_001086102.2
Canis lupus familiaris (dog)TRAF3IP2XP_532266.3
Bos taurus (cattle)TRAF3IP2NP_001030560.1
Mus musculus (house mouse)Traf3ip2NP_598761.2
Rattus norvegicus (Norway rat)Traf3ip2NP_001037713.1
Gallus gallus (chicken)TRAF3IP2XP_419782.1
Process
IDNameEvidence
GO:0001783B cell apoptotic processIEA
GO:0006959humoral immune responseIEA
GO:0035556intracellular signal transductionNAS
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signalingIEP
GO:0048305immunoglobulin secretionIEA
Component
IDNameEvidence
GO:0005575cellular_componentND
Function
IDNameEvidence
GO:0005515protein bindingIPI
GeneCards TRAF3IP2
UniProt O43734
Vega OTTHUMG00000015379
MIM 607043
Ensembl ENSG00000056972
HGNC 1343
HPRD 06129

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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