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SRCAP Snf2-related CREBBP activator protein [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_006662 Homo sapiens Snf2-related CREBBP activator protein (SRCAP), mRNA. GenEZ ORF Cloning On-demand $4749.00 40

*Business Day

Related Services

Gene Symbol SRCAP
Entrez Gene ID 10847
Full Name Snf2-related CREBBP activator protein
Synonyms DOMO1, EAF1, FLHS, SWR1
General protein information
Preferred Names
helicase SRCAP
Names
helicase SRCAP
domino homolog 2
Snf2-related CBP activator protein
Swi2/Snf2-related ATPase homolog, domino homolog 1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

16

16p11.2

Summary This gene encodes the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex. The encoded protein is an ATPase that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. It can function as a transcriptional activator in Notch-mediated, CREB-mediated and steroid receptor-mediated transcription. Mutations in this gene cause Floating-Harbor syndrome, a rare disorder characterized by short stature, language deficits and dysmorphic facial features. [provided by RefSeq, Feb 2012].
Disorder

MIM: 611421

mRNA Protein Product Sequence Price Select
NM_006662, 146219842 NP_006653, 146219843 helicase SRCAP ORF Sequence $4500.00
Homo sapiens (human)SRCAPNP_006653.2
Pan troglodytes (chimpanzee)SRCAPXP_003315112.1
Macaca mulatta (Rhesus monkey)SRCAPXP_002802498.1
Canis lupus familiaris (dog)SRCAPXP_005621350.1
Bos taurus (cattle)SRCAPXP_003587880.1
Mus musculus (house mouse)SrcapXP_006508489.1
Rattus norvegicus (Norway rat)SrcapXP_006230438.1
Process
IDNameEvidence
GO:0006351transcription, DNA-templatedIEA
GO:0006357regulation of transcription from RNA polymerase II promoterTAS
GO:0016032viral processIEA
GO:0016573histone acetylationTAS
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005794Golgi apparatusIDA
GO:0043234protein complexIDA
Function
IDNameEvidence
GO:0003677DNA bindingIEA
GO:0003713transcription coactivator activityTAS
GO:0004386helicase activityIEA
GO:0004402histone acetyltransferase activityTAS
GO:0005524ATP bindingIEA
GeneCards SRCAP
UniProt Q6ZRS2
Vega OTTHUMG00000132393
MIM 611421
Ensembl ENSG00000080603
HGNC 16974
HPRD 18103

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the SRCAP gene?

The SRCAP gene provides instructions for making a protein called Snf2-related CREBBP activator protein, or SRCAP. SRCAP is one of several proteins that help activate a gene called CREBBP. The protein produced from the CREBBP gene, called CREB binding protein, plays a key role in regulating cell growth and division and is important for normal development.

Interactant

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