Sequence in raw or FASTA format:
SRCAP Snf2-related CREBBP activator protein [
Homo sapiens (human)]
Gene Symbol SRCAP
Entrez Gene ID
Full Name Snf2-related CREBBP activator protein
Synonyms DOMO1, EAF1, FLHS, SWR1
General protein information
domino homolog 2
Snf2-related CBP activator protein
Swi2/Snf2-related ATPase homolog, domino homolog 1
Gene Type protein-coding
Homo sapiens (human)
Chromosome:16 Map Location:16p11.2
Summary This gene encodes the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex. The encoded protein is an ATPase that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. It can function as a transcriptional activator in Notch-mediated, CREB-mediated and steroid receptor-mediated transcription. Mutations in this gene cause Floating-Harbor syndrome, a rare disorder characterized by short stature, language deficits and dysmorphic facial features. [provided by RefSeq, Feb 2012].
Related articles in PubMed Floating-Harbor Syndrome Nowaczyk MJM, et al. , 1993. PMID 23193612. A census of human soluble protein complexes. Havugimana PC, et al. Cell, 2012 Aug 31. PMID 22939629. Gene reactivation by 5-aza-2'-deoxycytidine-induced demethylation requires SRCAP-mediated H2A.Z insertion to establish nucleosome depleted regions. Yang X, et al. PLoS Genet, 2012. PMID 22479200. H2A.Z.2.2 is an alternatively spliced histone H2A.Z variant that causes severe nucleosome destabilization. Bönisch C, et al. Nucleic Acids Res, 2012 Jul. PMID 22467210. Mutations in SRCAP, encoding SNF2-related CREBBP activator protein, cause Floating-Harbor syndrome. Hood RL, et al. Am J Hum Genet, 2012 Feb 10. PMID 22265015. See all (39) citations in PubMed See citations in PubMed for homologs of this gene provided by HomoloGene
GeneRIFs: Gene References Into Functions
What's a GeneRIF?
Our genome-wide expression results demonstrate that SRCAP-mediated H2A.Z deposition at promoter regions is necessary for complete gene reactivation induced by DNA demethylation.
Title: Gene reactivation by 5-aza-2'-deoxycytidine-induced demethylation requires SRCAP-mediated H2A.Z insertion to establish nucleosome depleted regions.
Sanger sequencing identified mutations in SRCAP in eight more affected persons.
Title: Mutations in SRCAP, encoding SNF2-related CREBBP activator protein, cause Floating-Harbor syndrome.
HCV NS3 protein is involved in the activation of the Notch-signaling pathway through the targeting to both SRCAP and p400
Title: Hepatitis C virus NS3 protein can activate the Notch-signaling pathway through binding to a transcription factor, SRCAP.
These data identify SRCAP as a physiologically relevant mediator of PSA expression, and demonstrate that SRCAP plays a role in prostate cancer cell proliferation.
Title: The chromatin remodeling factor SRCAP modulates expression of prostate specific antigen and cellular proliferation in prostate cancer cells.
SRCAP is recruited to promoters and is critical for the deposition of H2A.Z.
Title: The chromatin remodeling protein, SRCAP, is critical for deposition of the histone variant H2A.Z at promoters.
SRCAP-containing complex supports ATP-dependent exchange of histone dimers containing H2B and H2A.Z into mononucleosomes reconstituted with recombinant H2A, H2B, H3, and H4.
Title: Purification of a human SRCAP complex that remodels chromatin by incorporating the histone variant H2A.Z into nucleosomes.
SRCAP is implicated in developmental gene activation
Title: Human SRCAP and Drosophila melanogaster DOM are homologs that function in the notch signaling pathway.
Methods for purification and assay of the SRCAP chromatin remodeling complexes are described.
Title: Purification and assay of the human INO80 and SRCAP chromatin remodeling complexes.
Results identify YL1 as a subunit of the TRRAP/TIP60 HAT complex, and also as a component of a novel mammalian multiprotein complex that includes the SNF2-related helicase SRCAP.
Title: The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes.
SRCAP functions as a coactivator to regulate transcription initiated by several signaling pathways.
Title: SNF2-related CBP activator protein (SRCAP) functions as a coactivator of steroid receptor-mediated transcription through synergistic interactions with CARM-1 and GRIP-1.
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