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Sequence in raw or FASTA format:


Blast Method:


CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_006668 Homo sapiens cytochrome P450, family 46, subfamily A, polypeptide 1 (CYP46A1), mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_005267274 PREDICTED: Homo sapiens cytochrome P450, family 46, subfamily A, polypeptide 1 (CYP46A1), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $549.00 14

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Gene Symbol CYP46A1
Entrez Gene ID 10858
Full Name cytochrome P450, family 46, subfamily A, polypeptide 1
Synonyms CP46, CYP46
General protein information
Preferred Names
cholesterol 24-hydroxylase
cholesterol 24-hydroxylase
cytochrome P450 46A1
cytochrome P450, subfamily 46 (cholesterol 24-hydroxylase)
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism. [provided by RefSeq, Jul 2008].

MIM: 604087

mRNA Protein Product Sequence Price Select
NM_006668, 5729795 NP_006659, 5729796 cholesterol 24-hydroxylase precursor ORF Sequence $550.00
XM_005267274, 578825418 XP_005267331, 530402972 cholesterol 24-hydroxylase isoform X1 ORF Sequence $400.00
hsa00120Primary bile acid biosynthesis
WP43cytochrome P450
WP702metapathway biotransformation
REACT_13433Biological oxidations
REACT_13567Cytochrome P450 - arranged by substrate type
REACT_13812Endogenous sterols
REACT_13705Phase 1 - Functionalization of compounds
REACT_11040Bile acid and bile salt metabolism
REACT_11053Synthesis of bile acids and bile salts via 24-hydroxycholesterol
REACT_11054Synthesis of bile acids and bile salts
REACT_22258Metabolism of lipids and lipoproteins
Homo sapiens (human)CYP46A1NP_006659.1
Pan troglodytes (chimpanzee)CYP46A1XP_510158.3
Macaca mulatta (Rhesus monkey)LOC705843XP_001103455.2
Canis lupus familiaris (dog)CYP46A1XP_005623990.1
Bos taurus (cattle)CYP46A1NP_001070278.1
Mus musculus (house mouse)Cyp46a1NP_034140.1
Rattus norvegicus (Norway rat)Cyp46a1NP_001102193.1
Gallus gallus (chicken)CYP46A1NP_001238956.1
Arabidopsis thaliana (thale cress)CYP97A3NP_564384.1
Xenopus (Silurana) tropicalis (western clawed frog)mgc108213NP_001027517.1
Xenopus (Silurana) tropicalis (western clawed frog)mgc108077NP_001027519.1
Xenopus (Silurana) tropicalis (western clawed frog)cyp46a1NP_001072550.1
GO:0006699bile acid biosynthetic processTAS
GO:0006707cholesterol catabolic processIDA
GO:0006805xenobiotic metabolic processIDA
GO:0006805xenobiotic metabolic processTAS
GO:0007399nervous system developmentTAS
GO:0008206bile acid metabolic processTAS
GO:0016125sterol metabolic processTAS
GO:0044281small molecule metabolic processTAS
GO:0055114oxidation-reduction processIEA
GO:0005783endoplasmic reticulumTAS
GO:0005789endoplasmic reticulum membraneTAS
GO:0016021integral component of membraneIEA
GO:0005506iron ion bindingIEA
GO:0008395steroid hydroxylase activityTAS
GO:0020037heme bindingIDA
GO:0033781cholesterol 24-hydroxylase activityIDA
GeneCards CYP46A1
PDB 3MDV, 4ENH, 3MDR, 4FIA, 2Q9G, 3MDT, 2Q9F, 3MDM, 4J14
UniProt Q9Y6A2
Vega OTTHUMG00000171510
MIM 604087
Ensembl ENSG00000036530
HGNC 2641
HPRD 04970

GeneRIFs: Gene References Into Functions What's a GeneRIF?


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