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CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_006668 Homo sapiens cytochrome P450, family 46, subfamily A, polypeptide 1 (CYP46A1), mRNA. GenEZ ORF Cloning On-demand $699.00 18

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Gene Symbol CYP46A1
Entrez Gene ID 10858
Full Name cytochrome P450, family 46, subfamily A, polypeptide 1
Synonyms CP46, CYP46
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism. [provided by RefSeq, Jul 2008].

MIM: 604087

mRNA Protein Product Sequence Price Select
NM_006668, 5729795 NP_006659, 5729796 cholesterol 24-hydroxylase precursor ORF Sequence $550.00
hsa00120Primary bile acid biosynthesis
WP43cytochrome P450
WP702metapathway biotransformation
REACT_13812Endogenous sterols
REACT_22258Metabolism of lipids and lipoproteins
REACT_13705Phase 1 - Functionalization of compounds
REACT_11054Synthesis of bile acids and bile salts
REACT_11040Bile acid and bile salt metabolism
REACT_13433Biological oxidations
REACT_13567Cytochrome P450 - arranged by substrate type
REACT_11053Synthesis of bile acids and bile salts via 24-hydroxycholesterol
Homo sapiens (human)CYP46A1NP_006659.1
Pan troglodytes (chimpanzee)CYP46A1XP_510158.3
Canis lupus familiaris (dog)CYP46A1XP_537552.3
Bos taurus (cattle)CYP46A1NP_001070278.1
Mus musculus (house mouse)Cyp46a1NP_034140.1
Rattus norvegicus (Norway rat)Cyp46a1NP_001102193.1
Gallus gallus (chicken)CYP46A1NP_001238956.1
Danio rerio (zebrafish)cyp46a1NP_001018358.1
Danio rerio (zebrafish)cyp46a2NP_956773.1
Danio rerio (zebrafish)LOC100329425XP_003200717.1
Danio rerio (zebrafish)zgc:63602NP_956755.1
Danio rerio (zebrafish)zgc:136808NP_001038763.1
Arabidopsis thaliana (thale cress)LUT1NP_190881.2
GeneCards CYP46A1
PDB 3MDV, 4ENH, 3MDR, 4FIA, 2Q9G, 3MDT, 2Q9F, 3MDM
UniProt Q9Y6A2
MIM 604087
Ensembl ENSG00000036530
HGNC 2641
HPRD 04970

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
cholesterol 24-hydroxylase
cholesterol 24-hydroxylase
cytochrome P450 46A1
cytochrome P450, subfamily 46 (cholesterol 24-hydroxylase)


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