UTS2 urotensin 2 [Homo sapiens (human)]
| Gene Symbol | UTS2 |
| Entrez Gene ID | 10911 |
| Full Name | urotensin 2 |
| Synonyms | PRO1068, U-II, UCN2, UII |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
1 1p36 |
| Summary | This gene encodes a mature peptide that is an active cyclic heptapeptide absolutely conserved from lamprey to human. The active peptide acts as a vasoconstrictor and is expressed only in brain tissue. Despite the gene family name similarity, this gene is not homologous to urocortin, a member of the sauvagine/corticotropin-releasing factor/urotensin I family. Most of the proprotein is cleaved to make the mature peptide. Transcript variants encoding different preproprotein isoforms have been described for this gene. [provided by RefSeq]. |
| Disorder | MIM: 604097 |
| mRNA | NM_021995, 209977034 |
| Protein | NP_068835, 12056479 |
| Product | urotensin-2 isoform a preproprotein |
| RefSeq Status | REVIEWED |
| mRNA | NM_006786, 209977037 |
| Protein | NP_006777, 5803209 |
| Product | urotensin-2 isoform b preproprotein |
| RefSeq Status | REVIEWED |
| REACT_18283 | G alpha (q) signalling events |
| REACT_19184 | GPCR downstream signaling |
| REACT_14797 | Signaling by GPCR |
| REACT_14828 | Class A/1 (Rhodopsin-like receptors) |
| REACT_21340 | GPCR ligand binding |
| REACT_14819 | Peptide ligand-binding receptors |
| Homo sapiens (human) | UTS2 | NP_006777.1 |
| Pan troglodytes (chimpanzee) | UTS2 | XP_001157678.1 |
| Mus musculus (house mouse) | Uts2 | NP_036040.1 |
| Rattus norvegicus (Norway rat) | Uts2 | NP_062033.1 |
| ID | Name | Evidence |
| GO:0006936 | muscle contraction | TAS |
| GO:0007268 | synaptic transmission | TAS |
| GO:0008217 | regulation of blood pressure | TAS |
Component
| ID | Name | Evidence |
| GO:0005576 | extracellular region | EXP |
| GO:0005576 | extracellular region | TAS |
| GO:0005615 | extracellular space | TAS |
Function
| ID | Name | Evidence |
| GO:0005102 | receptor binding | TAS |
| GO:0005179 | hormone activity | IEA |
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