YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide [Homo sapiens (human)]
| Gene Symbol | YWHAQ |
| Entrez Gene ID | 10971 |
| Full Name | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide |
| Synonyms | 14-3-3, 1C5, HS1 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
2 2p25.1 |
| Summary | This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease. [provided by RefSeq]. |
| Disorder | MIM: 609009 |
| mRNA | NM_006826, 21464103 |
| Protein | NP_006817, 5803227 |
| Product | 14-3-3 protein theta |
| RefSeq Status | REVIEWED |
| hsa05130 | Pathogenic Escherichia coli infection |
| hsa04110 | Cell cycle |
| hsa04114 | Oocyte meiosis |
| hsa04722 | Neurotrophin signaling pathway |
Pathway Interaction Database
| pi3kciaktpathway | Class I PI3K signaling events mediated by Akt |
| nfat_3pathway | Role of Calcineurin-dependent NFAT signaling in lymphocytes |
| foxopathway | FoxO family signaling |
| insulin_glucose_pathway | Insulin-mediated glucose transport |
| a6b1_a6b4_integrin_pathway | a6b1 and a6b4 Integrin signaling |
| mtor_4pathway | mTOR signaling pathway |
| pi3kplctrkpathway | Trk receptor signaling mediated by PI3K and PLC-gamma |
| erbb1_downstream_pathway | ErbB1 downstream signaling |
| p38_mk2pathway | p38 signaling mediated by MAPKAP kinases |
| lkb1_pathway | LKB1 signaling events |
| wnt_beta_catenin_pathway | Regulation of Wnt-mediated beta catenin signaling and target gene transcription |
WikiPathways
| WP244 | Alpha6-Beta4 Integrin Signaling Pathway |
| WP289 | Myometrial Relaxation and Contraction Pathways |
| WP286 | IL-3 Signaling Pathway |
| WP536 | Calcium Regulation in the Cardiac Cell |
| WP231 | TNF-alpha/NF-kB Signaling Pathway |
| WP69 | T Cell Receptor Signaling Pathway |
| Homo sapiens (human) | YWHAQ | NP_006817.1 |
| Pan troglodytes (chimpanzee) | YWHAQ | XP_525684.2 |
| Canis lupus familiaris (dog) | YWHAQ | XP_532871.1 |
| Bos taurus (cattle) | YWHAQ | NP_001071595.1 |
| Mus musculus (house mouse) | Gm2423 | XP_001473550.1 |
| ID | Name | Evidence |
| GO:0006605 | protein targeting | IEA |
| GO:0007264 | small GTPase mediated signal transduction | IEA |
| GO:0045892 | negative regulation of transcription, DNA-dependent | IDA |
Component
| ID | Name | Evidence |
| GO:0005625 | soluble fraction | IEA |
| GO:0005634 | nucleus | IDA |
| GO:0005730 | nucleolus | IDA |
| GO:0005737 | cytoplasm | IDA |
| GO:0005813 | centrosome | IDA |
| GO:0043234 | protein complex | IEA |
Function
| ID | Name | Evidence |
| GO:0005515 | protein binding | IPI |
| GO:0019904 | protein domain specific binding | IEA |
| GO:0047485 | protein N-terminus binding | IPI |
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