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YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu16909 NM_006826 Homo sapiens tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta (YWHAQ), mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu16909C NM_006826 Homo sapiens tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta (YWHAQ), mRNA. Customized vector In-stock 5-7 $149.00

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Gene Symbol YWHAQ
Entrez Gene ID 10971
Full Name tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
Synonyms 14-3-3, 1C5, HS1
General protein information
Preferred Names
14-3-3 protein theta
Names
14-3-3 protein theta
14-3-3 protein tau
14-3-3 protein T-cell
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

2

2p25.1

Summary This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease. [provided by RefSeq, Jul 2008].
Disorder

MIM: 609009

mRNA Protein Product Sequence Price Select
NM_006826, 514052668 NP_006817, 5803227 14-3-3 protein theta ORF Sequence $159.00
KEGG
hsa04110Cell cycle
hsa05130Pathogenic Escherichia coli infection
hsa04114Oocyte meiosis
hsa04151PI3K-Akt signaling pathway
hsa05161Hepatitis B
hsa04390Hippo signaling pathway
hsa05169Epstein-Barr virus infection
hsa05203Viral carcinogenesis
WikiPathways
WP244Alpha6-Beta4 Integrin Signaling Pathway
WP289Myometrial Relaxation and Contraction Pathways
WP179Cell cycle
WP231TNF-alpha/NF-kB Signaling Pathway
WP706SIDS Susceptibility Pathways
WP536Calcium Regulation in the Cardiac Cell
WP286IL-3 Signaling Pathway
WP2272Pathogenic Escherichia coli infection
Pathway Interaction Database
lkb1_pathwayLKB1 signaling events
insulin_glucose_pathwayInsulin-mediated glucose transport
pi3kciaktpathwayClass I PI3K signaling events mediated by Akt
nfat_3pathwayRole of Calcineurin-dependent NFAT signaling in lymphocytes
pi3kplctrkpathwayTrk receptor signaling mediated by PI3K and PLC-gamma
erbb1_downstream_pathwayErbB1 downstream signaling
a6b1_a6b4_integrin_pathwaya6b1 and a6b4 Integrin signaling
p38_mk2pathwayp38 signaling mediated by MAPKAP kinases
foxopathwayFoxO family signaling
mtor_4pathwaymTOR signaling pathway
wnt_beta_catenin_pathwayRegulation of Wnt-mediated beta catenin signaling and target gene transcription
Reactome
REACT_549Activation of BAD and translocation to mitochondria
REACT_964Intrinsic Pathway for Apoptosis
REACT_697Activation of BH3-only proteins
REACT_578Apoptosis
REACT_11123Membrane Trafficking
REACT_147867Translocation of GLUT4 to the plasma membrane
Homo sapiens (human)YWHAQNP_006817.1
Pan troglodytes (chimpanzee)YWHAQXP_003949798.1
Macaca mulatta (Rhesus monkey)YWHAQXP_001097635.1
Canis lupus familiaris (dog)YWHAQXP_532871.1
Bos taurus (cattle)YWHAQNP_001071595.1
Mus musculus (house mouse)YwhaqNP_035869.1
Mus musculus (house mouse)LOC102634437XP_006538470.1
Rattus norvegicus (Norway rat)YwhaqNP_037185.1
Gallus gallus (chicken)YWHAQNP_001006415.1
Danio rerio (zebrafish)ywhaqbNP_958892.1
Xenopus (Silurana) tropicalis (western clawed frog)ywhaqNP_001025570.1
Process
IDNameEvidence
GO:0006605protein targetingIEA
GO:0006915apoptotic processTAS
GO:0007264small GTPase mediated signal transductionIEA
GO:0021762substantia nigra developmentIEP
GO:0045892negative regulation of transcription, DNA-templatedIDA
GO:0061024membrane organizationTAS
GO:0097193intrinsic apoptotic signaling pathwayTAS
GO:1900740positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathwayTAS
Component
IDNameEvidence
GO:0005737cytoplasmIDA
GO:0005829cytosolTAS
GO:0016020membraneIDA
GO:0030659cytoplasmic vesicle membraneTAS
GO:0070062extracellular vesicular exosomeIDA
Function
IDNameEvidence
GO:0005515protein bindingIPI
GO:0019904protein domain specific bindingIEA
GO:0047485protein N-terminus bindingIPI
GeneCards YWHAQ
PDB 2BTP
UniProt P27348
Vega OTTHUMG00000013848
MIM 609009
Ensembl ENSG00000134308
HGNC 12854
HPRD 00886

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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