• THAT   AND
  • THAT   AND


Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


SPINK5 serine peptidase inhibitor, Kazal type 5 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001127698 Homo sapiens serine peptidase inhibitor, Kazal type 5 (SPINK5), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand TBD TBD
NM_001127699 Homo sapiens serine peptidase inhibitor, Kazal type 5 (SPINK5), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand TBD TBD
NM_006846 Homo sapiens serine peptidase inhibitor, Kazal type 5 (SPINK5), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand TBD TBD

*Business Day

Related Services

Gene Symbol SPINK5
Entrez Gene ID 11005
Full Name serine peptidase inhibitor, Kazal type 5
Synonyms LEKTI, LETKI, NETS, NS, VAKTI
General protein information
Preferred Names
serine protease inhibitor Kazal-type 5
Names
serine protease inhibitor Kazal-type 5
serine protease inhibitor, Kazal type 5
lymphoepithelial Kazal-type-related inhibitor
lympho-epithelial Kazal-type-related inhibitor
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

5

5q32

Summary This gene encodes a multidomain serine protease inhibitor that contains 15 potential inhibitory domains. The inhibitor may play a role in skin and hair morphogenesis and anti-inflammatory and/or antimicrobial protection of mucous epithelia. Mutations may result in Netherton syndrome, a disorder characterized by ichthyosis, defective cornification, and atopy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Disorder

MIM: 605010

Netherton syndrome, 256500 (3); Atopy, 147050 (3)

mRNA Protein Product Sequence Price Select
NM_001127698, 189163500 NP_001121170, 189163501 serine protease inhibitor Kazal-type 5 isoform a precursor ORF Sequence $1500.00
NM_001127699, 189163503 NP_001121171, 189163504 serine protease inhibitor Kazal-type 5 isoform c precursor ORF Sequence $750.00
NM_006846, 189163502 NP_006837, 74027261 serine protease inhibitor Kazal-type 5 isoform b precursor ORF Sequence $1500.00
Homo sapiens (human)SPINK5NP_001121170.1
Pan troglodytes (chimpanzee)SPINK5XP_001160618.1
Macaca mulatta (Rhesus monkey)SPINK5XP_001103296.1
Canis lupus familiaris (dog)SPINK5NP_001020568.1
Bos taurus (cattle)SPINK5NP_001095572.1
Mus musculus (house mouse)Spink5NP_001074649.1
Rattus norvegicus (Norway rat)Spink5NP_001164077.1
Rattus norvegicus (Norway rat)LOC100910851XP_003749120.1
Gallus gallus (chicken)SPINK5XP_004944964.1
Gallus gallus (chicken)SPINK7NP_001106132.1
Process
IDNameEvidence
GO:0009913epidermal cell differentiationIDA
GO:0010951negative regulation of endopeptidase activityIDA
GO:0010951negative regulation of endopeptidase activityIEA
GO:0016525negative regulation of angiogenesisTAS
GO:0030155regulation of cell adhesionIEA
GO:0030198extracellular matrix organizationTAS
GO:0030855epithelial cell differentiationTAS
GO:0035315hair cell differentiationTAS
GO:0042640anagenTAS
GO:0045580regulation of T cell differentiationTAS
GO:0045861negative regulation of proteolysisIEA
GO:0050777negative regulation of immune responseTAS
Component
IDNameEvidence
GO:0005576extracellular regionIDA
GO:0005576extracellular regionNAS
GO:0005737cytoplasmIDA
GO:0005783endoplasmic reticulumIDA
GO:0005789endoplasmic reticulum membraneIDA
GO:0005829cytosolIDA
GO:0005938cell cortexIDA
GO:0048471perinuclear region of cytoplasmIDA
GO:0070062extracellular vesicular exosomeIDA
GO:0097209epidermal lamellar bodyIDA
Function
IDNameEvidence
GO:0004867serine-type endopeptidase inhibitor activityIDA
GeneCards SPINK5
UniProt Q9NQ38
Vega OTTHUMG00000134305
MIM 605010
Ensembl ENSG00000133710
HGNC 15464
HPRD 05423

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the SPINK5 gene?

The SPINK5 gene provides instructions for making a protein called LEKT1. LEKT1 is a type of serine peptidase inhibitor. Serine peptidase inhibitors control the activity of enzymes called serine peptidases, which break down other proteins. LEKT1 is found in the skin and in the thymus, which is a gland located behind the breastbone that plays an important role in the immune system by producing white blood cells called lymphocytes. LEKT1 controls the activity of certain serine peptidases in the outer layer of skin (the epidermis), especially the tough outer surface known as the stratum corneum, which provides a sturdy barrier between the body and its environment. Serine peptidase enzymes are involved in normal skin shedding by helping to break the connections between cells of the stratum corneum. LEKT1 is also involved in normal hair growth, the development of lymphocytes in the thymus, and the control of peptidases that trigger immune system function.

Interactant

Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.