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SPINK5 serine peptidase inhibitor, Kazal type 5 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu19403 NM_006846 Homo sapiens serine peptidase inhibitor, Kazal type 5 (SPINK5), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand -1 TBD
OHu31774 NM_001127699 Homo sapiens serine peptidase inhibitor, Kazal type 5 (SPINK5), transcript variant 3, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu31833 NM_001127698 Homo sapiens serine peptidase inhibitor, Kazal type 5 (SPINK5), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand -1 TBD
OHu19403C NM_006846 Homo sapiens serine peptidase inhibitor, Kazal type 5 (SPINK5), transcript variant 2, mRNA. Customized vector On-demand -1 TBD
OHu31774C NM_001127699 Homo sapiens serine peptidase inhibitor, Kazal type 5 (SPINK5), transcript variant 3, mRNA. Customized vector On-demand 12-14 $329.00
OHu31833C NM_001127698 Homo sapiens serine peptidase inhibitor, Kazal type 5 (SPINK5), transcript variant 1, mRNA. Customized vector On-demand -1 TBD

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Gene Symbol SPINK5
Entrez Gene ID 11005
Full Name serine peptidase inhibitor, Kazal type 5
Synonyms LEKTI, LETKI, NETS, NS, VAKTI
General protein information
Preferred Names
serine protease inhibitor Kazal-type 5
Names
serine protease inhibitor Kazal-type 5
serine protease inhibitor, Kazal type 5
lymphoepithelial Kazal-type-related inhibitor
lympho-epithelial Kazal-type-related inhibitor
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

5

5q32

Summary This gene encodes a multidomain serine protease inhibitor that contains 15 potential inhibitory domains. The inhibitor may play a role in skin and hair morphogenesis and anti-inflammatory and/or antimicrobial protection of mucous epithelia. Mutations may result in Netherton syndrome, a disorder characterized by ichthyosis, defective cornification, and atopy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Disorder

MIM: 605010

Netherton syndrome, 256500 (3); Atopy, 147050 (3)

mRNA Protein Product Sequence Price Select
NM_001127698, 189163500 NP_001121170, 189163501 serine protease inhibitor Kazal-type 5 isoform a precursor ORF Sequence $1500.00
NM_001127699, 189163503 NP_001121171, 189163504 serine protease inhibitor Kazal-type 5 isoform c precursor ORF Sequence $750.00
NM_006846, 189163502 NP_006837, 74027261 serine protease inhibitor Kazal-type 5 isoform b precursor ORF Sequence $1500.00
Homo sapiens (human)SPINK5NP_001121170.1
Pan troglodytes (chimpanzee)SPINK5XP_001160618.1
Macaca mulatta (Rhesus monkey)SPINK5XP_001103296.1
Canis lupus familiaris (dog)SPINK5NP_001020568.1
Bos taurus (cattle)SPINK5NP_001095572.1
Mus musculus (house mouse)Spink5NP_001074649.1
Rattus norvegicus (Norway rat)Spink5NP_001164077.1
Rattus norvegicus (Norway rat)LOC100910851XP_003749120.1
Gallus gallus (chicken)SPINK5XP_004944964.1
Gallus gallus (chicken)SPINK7NP_001106132.1
Process
IDNameEvidence
GO:0009913epidermal cell differentiationIDA
GO:0010951negative regulation of endopeptidase activityIDA
GO:0010951negative regulation of endopeptidase activityIEA
GO:0016525negative regulation of angiogenesisTAS
GO:0030155regulation of cell adhesionIEA
GO:0030198extracellular matrix organizationTAS
GO:0030855epithelial cell differentiationTAS
GO:0035315hair cell differentiationTAS
GO:0042640anagenTAS
GO:0045580regulation of T cell differentiationTAS
GO:0045861negative regulation of proteolysisIEA
GO:0050777negative regulation of immune responseTAS
Component
IDNameEvidence
GO:0005576extracellular regionIDA
GO:0005576extracellular regionNAS
GO:0005737cytoplasmIDA
GO:0005783endoplasmic reticulumIDA
GO:0005789endoplasmic reticulum membraneIDA
GO:0005829cytosolIDA
GO:0005938cell cortexIDA
GO:0048471perinuclear region of cytoplasmIDA
GO:0070062extracellular vesicular exosomeIDA
GO:0097209epidermal lamellar bodyIDA
Function
IDNameEvidence
GO:0004867serine-type endopeptidase inhibitor activityIDA
GeneCards SPINK5
UniProt Q9NQ38
Vega OTTHUMG00000134305
MIM 605010
Ensembl ENSG00000133710
HGNC 15464
HPRD 05423

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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