• THAT   AND
  • THAT   AND


Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu23357 NM_139027 Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif, 13 (ADAMTS13), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand TBD TBD
OHu27537 NM_139025 Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif, 13 (ADAMTS13), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand TBD TBD
OHu27548 NM_139026 Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif, 13 (ADAMTS13), transcript variant 3, mRNA. pcDNA3.1+-DYK On-demand TBD TBD
OHu23357C NM_139027 Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif, 13 (ADAMTS13), transcript variant 2, mRNA. Customized vector On-demand TBD TBD
OHu27537C NM_139025 Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif, 13 (ADAMTS13), transcript variant 1, mRNA. Customized vector On-demand TBD TBD
OHu27548C NM_139026 Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif, 13 (ADAMTS13), transcript variant 3, mRNA. Customized vector On-demand TBD TBD

*Business Day

Related Services

Gene Symbol ADAMTS13
Entrez Gene ID 11093
Full Name ADAM metallopeptidase with thrombospondin type 1 motif, 13
Synonyms ADAM-TS13, ADAMTS-13, C9orf8, VWFCP, vWF-CP
General protein information
Preferred Names
A disintegrin and metalloproteinase with thrombospondin motifs 13
Names
A disintegrin and metalloproteinase with thrombospondin motifs 13
vWF-cleaving protease
von Willebrand factor-cleaving protease
a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 13
NP_620594.1
NP_620595.1
NP_620596.2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

9

9q34

Summary This gene encodes a member of a family of proteins containing several distinct regions, including a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. The enzyme encoded by this gene specifically cleaves von Willebrand Factor (vWF). Defects in this gene are associated with thrombotic thrombocytopenic purpura. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
Disorder

MIM: 604134

Thrombotic thrombocytopenic purpura, familial, 274150 (3)

mRNA Protein Product Sequence Price Select
NM_139025, 525313719 NP_620594, 21265034 A disintegrin and metalloproteinase with thrombospondin motifs 13 isoform 1 preproprotein ORF Sequence $1500.00
NM_139026, 525313726 NP_620595, 21265043 A disintegrin and metalloproteinase with thrombospondin motifs 13 isoform 3 preproprotein ORF Sequence $1500.00
NM_139027, 525313722 NP_620596, 73695936 A disintegrin and metalloproteinase with thrombospondin motifs 13 isoform 2 preproprotein ORF Sequence $1500.00
Reactome
REACT_17015Metabolism of proteins
REACT_22161Post-translational protein modification
REACT_200727O-linked glycosylation
REACT_200626O-glycosylation of TSR domain-containing proteins
Homo sapiens (human)ADAMTS13NP_620594.1
Pan troglodytes (chimpanzee)ADAMTS13XP_003312433.1
Canis lupus familiaris (dog)ADAMTS13NP_001229641.1
Bos taurus (cattle)ADAMTS13XP_002691670.2
Mus musculus (house mouse)Adamts13NP_001001322.1
Rattus norvegicus (Norway rat)LOC102554393XP_006233941.1
Gallus gallus (chicken)ADAMTS13XP_415435.4
Danio rerio (zebrafish)adamts13XP_002663267.3
Xenopus (Silurana) tropicalis (western clawed frog)adamts13XP_002942962.2
Process
IDNameEvidence
GO:0006508proteolysisIDA
GO:0007160cell-matrix adhesionNAS
GO:0007229integrin-mediated signaling pathwayNAS
GO:0009100glycoprotein metabolic processNAS
GO:0016485protein processingTAS
GO:0030168platelet activationNAS
GO:0034341response to interferon-gammaIEA
GO:0034612response to tumor necrosis factorIEA
GO:0043171peptide catabolic processIDA
GO:0070670response to interleukin-4IEA
Component
IDNameEvidence
GO:0005578proteinaceous extracellular matrixTAS
GO:0005615extracellular spaceIEA
GO:0009986cell surfaceNAS
Function
IDNameEvidence
GO:0004222metalloendopeptidase activityIEA
GO:0005178integrin bindingTAS
GO:0005509calcium ion bindingTAS
GO:0005515protein bindingIPI
GO:0008237metallopeptidase activityTAS
GO:0008270zinc ion bindingTAS
GeneCards ADAMTS13
UniProt Q76LX8
Vega OTTHUMG00000020876
MIM 604134
Ensembl ENSG00000160323
HGNC 1366
HPRD 04994

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.