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POLR3A polymerase (RNA) III (DNA directed) polypeptide A, 155kDa [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_007055 Homo sapiens polymerase (RNA) III (DNA directed) polypeptide A, 155kDa (POLR3A), mRNA. GenEZ ORF Cloning On-demand $1699.00 25
XM_006717597 PREDICTED: Homo sapiens polymerase (RNA) III (DNA directed) polypeptide A, 155kDa (POLR3A), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $1699.00 25

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Related Services

Gene Symbol POLR3A
Entrez Gene ID 11128
Full Name polymerase (RNA) III (DNA directed) polypeptide A, 155kDa
Synonyms ADDH, HLD7, RPC1, RPC155, hRPC155
General protein information
Preferred Names
DNA-directed RNA polymerase III subunit RPC1
Names
DNA-directed RNA polymerase III subunit RPC1
RNA polymerase III subunit C1
RNA polymerase III subunit C160
RNA polymerase III 155 kDa subunit
RNA polymerase III subunit RPC155-D
DNA-directed RNA polymerase III subunit A
DNA-directed RNA polymerase III largest subunit
NP_008986.2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

10

10q22-q23

Summary The protein encoded by this gene is the catalytic component of RNA polymerase III, which synthesizes small RNAs. The encoded protein also acts as a sensor to detect foreign DNA and trigger an innate immune response. [provided by RefSeq, Aug 2011].
Disorder

MIM: 614258

mRNA Protein Product Sequence Price Select
NM_007055, 296011005 NP_008986, 39725938 DNA-directed RNA polymerase III subunit RPC1 ORF Sequence $1500.00
XM_006717597, 578818841 XP_006717660, 578818842 DNA-directed RNA polymerase III subunit RPC1 isoform X1 ORF Sequence $1500.00
KEGG
hsa00240Pyrimidine metabolism
hsa00230Purine metabolism
hsa03020RNA polymerase
hsa04623Cytosolic DNA-sensing pathway
hsa_M00181RNA polymerase III, eukaryotes
hsa05169Epstein-Barr virus infection
Reactome
REACT_71Gene Expression
REACT_6802Innate Immune System
REACT_6900Immune System
REACT_1371RNA Polymerase III Transcription
REACT_281RNA Polymerase III Transcription Initiation
REACT_571RNA Polymerase III Transcription Initiation From Type 3 Promoter
REACT_756RNA Polymerase III Chain Elongation
REACT_347RNA Polymerase III Transcription Initiation From Type 1 Promoter
REACT_1036RNA Polymerase III Transcription Initiation From Type 2 Promoter
REACT_63RNA Polymerase III Transcription Termination
REACT_22339RNA Polymerase III Abortive And Retractive Initiation
REACT_21352RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
REACT_118823Cytosolic sensors of pathogen-associated DNA
Homo sapiens (human)POLR3ANP_008986.2
Pan troglodytes (chimpanzee)POLR3AXP_507865.4
Macaca mulatta (Rhesus monkey)POLR3AXP_002805710.1
Canis lupus familiaris (dog)POLR3AXP_536399.2
Bos taurus (cattle)POLR3ANP_001077219.1
Mus musculus (house mouse)Polr3aNP_001074716.1
Rattus norvegicus (Norway rat)Polr3aXP_341389.5
Gallus gallus (chicken)POLR3ANP_001006500.1
Danio rerio (zebrafish)polr3aNP_001263425.1
Drosophila melanogaster (fruit fly)CG17209NP_001096987.2
Caenorhabditis elegansrpc-1NP_501127.2
Arabidopsis thaliana (thale cress)NRPC1NP_200812.2
Xenopus (Silurana) tropicalis (western clawed frog)polr3aNP_001096178.1
Process
IDNameEvidence
GO:0006351transcription, DNA-templatedNAS
GO:0006383transcription from RNA polymerase III promoterTAS
GO:0006385transcription elongation from RNA polymerase III promoterTAS
GO:0006386termination of RNA polymerase III transcriptionTAS
GO:0010467gene expressionTAS
GO:0032481positive regulation of type I interferon productionTAS
GO:0032728positive regulation of interferon-beta productionIMP
GO:0045087innate immune responseIMP
GO:0045087innate immune responseTAS
GO:0051607defense response to virusIEA
Component
IDNameEvidence
GO:0005654nucleoplasmTAS
GO:0005666DNA-directed RNA polymerase III complexIDA
GO:0005829cytosolTAS
GO:0016020membraneIDA
Function
IDNameEvidence
GO:0001056RNA polymerase III activityIBA
GO:0003677DNA bindingIEA
GO:0003682chromatin bindingIEA
GO:0003899DNA-directed RNA polymerase activityNAS
GO:0008270zinc ion bindingIEA
GO:0032549ribonucleoside bindingIEA
GeneCards POLR3A
UniProt O14802
Vega OTTHUMG00000018550
MIM 614258
Ensembl ENSG00000148606
HGNC 30074
HPRD 17879

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the POLR3A gene?

The POLR3A gene provides instructions for making the largest part (subunit) of an enzyme called RNA polymerase III. This enzyme is involved in the production (synthesis) of ribonucleic acid (RNA), a chemical cousin of DNA. The RNA polymerase III enzyme attaches (binds) to DNA and synthesizes RNA in accordance with the instructions carried by the DNA, a process called transcription. RNA polymerase III helps synthesize several forms of RNA, including ribosomal RNA (rRNA) and transfer RNA (tRNA). Molecules of rRNA and tRNA assemble protein building blocks (amino acids) into working proteins; this process is essential for the normal functioning and survival of cells.

Interactant

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