PTP4A3 protein tyrosine phosphatase type IVA, member 3 [Homo sapiens (human)]
| Gene Symbol | PTP4A3 |
| Entrez Gene ID | 11156 |
| Full Name | protein tyrosine phosphatase type IVA, member 3 |
| Synonyms | PRL-3, PRL-R, PRL3 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
8 8q24.3 |
| Summary | The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs). PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This class of PTPs contain a PTP domain and a characteristic C-terminal prenylation motif. Studies of this class of PTPs in mice demonstrated that they were prenylated proteins in vivo, which suggested their association with cell plasma membrane. Overexpression of this gene in mammalian cells was reported to inhibit angiotensin-II induced cell calcium mobilization and promote cell growth. Two alternatively spliced variants exist. [provided by RefSeq]. |
| Disorder | MIM: 606449 |
| mRNA | NM_007079, 14589853 |
| Protein | NP_009010, 14589854 |
| Product | protein tyrosine phosphatase type IVA 3 isoform 2 |
| RefSeq Status | REVIEWED |
| mRNA | NM_032611, 14589855 |
| Protein | NP_116000, 14589856 |
| Product | protein tyrosine phosphatase type IVA 3 isoform 1 |
| RefSeq Status | REVIEWED |
| prlsignalingeventspathway | Signaling events mediated by PRL |
| Homo sapiens (human) | PTP4A3 | NP_116000.1 |
| Pan troglodytes (chimpanzee) | PTP4A3 | XP_001148895.1 |
| Canis lupus familiaris (dog) | PTP4A3 | XP_856381.1 |
| Mus musculus (house mouse) | Ptp4a3 | NP_033001.2 |
| Rattus norvegicus (Norway rat) | Ptp4a3 | XP_343260.3 |
| Gallus gallus (chicken) | PTP4A3 | XP_001231579.1 |
| Danio rerio (zebrafish) | ptp4a3 | NP_998346.1 |
| ID | Name | Evidence |
| GO:0005769 | early endosome | IEA |
| GO:0005886 | plasma membrane | IEA |
Function
| ID | Name | Evidence |
| GO:0004727 | prenylated protein tyrosine phosphatase activity | TAS |
| GO:0005515 | protein binding | IPI |
| GO:0008138 | protein tyrosine/serine/threonine phosphatase activity | IEA |
| GO:0016787 | hydrolase activity | IEA |
| GO:0042802 | identical protein binding | IPI |
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