ADCY6 adenylate cyclase 6 [Homo sapiens (human)]
| Gene Symbol | ADCY6 |
| Entrez Gene ID | 112 |
| Full Name | adenylate cyclase 6 |
| Synonyms | AC6, DKFZp779F075, KIAA0422 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
12 12q12-q13 |
| Summary | This gene encodes adenylate cyclase 6, which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). The expression of this gene is found in normal thyroid and brain tissues, as well as some tumors; and its expression is significantly higher in one hyperfunctioning thyroid tumor than in normal thyroid tissue. Alternative splicing generates 2 transcript variants. [provided by RefSeq]. |
| Disorder | MIM: 600294 |
| mRNA | NM_020983, 21071019 |
| Protein | NP_066193, 10947061 |
| Product | adenylate cyclase type 6 isoform b |
| RefSeq Status | REVIEWED |
| mRNA | NM_015270, 168480141 |
| Protein | NP_056085, 10181096 |
| Product | adenylate cyclase type 6 isoform a |
| RefSeq Status | REVIEWED |
| hsa04971 | Gastric acid secretion |
| hsa04914 | Progesterone-mediated oocyte maturation |
| hsa00230 | Purine metabolism |
| hsa04976 | Bile secretion |
| hsa04540 | Gap junction |
| hsa04970 | Salivary secretion |
| hsa04062 | Chemokine signaling pathway |
| hsa04962 | Vasopressin-regulated water reabsorption |
| hsa04114 | Oocyte meiosis |
| hsa04912 | GnRH signaling pathway |
| hsa05414 | Dilated cardiomyopathy |
| hsa04972 | Pancreatic secretion |
| hsa04742 | Taste transduction |
| hsa04916 | Melanogenesis |
| hsa04270 | Vascular smooth muscle contraction |
WikiPathways
| WP289 | Myometrial Relaxation and Contraction Pathways |
| WP536 | Calcium Regulation in the Cardiac Cell |
| WP35 | G Protein Signaling Pathways |
Pathway Interaction Database
| lpa4_pathway | LPA4-mediated signaling events |
| lysophospholipid_pathway | LPA receptor mediated events |
| endothelinpathway | Endothelins |
Reactome
| REACT_15380 | Diabetes pathways |
| REACT_12079 | PLC-gamma1 signalling |
| REACT_23887 | Aquaporin-mediated transport |
| REACT_15333 | Adenylate cyclase inhibitory pathway |
| REACT_9000 | Calmodulin induced events |
| REACT_19333 | G alpha (z) signalling events |
| REACT_18325 | Regulation of Insulin Secretion |
| REACT_24023 | Regulation of Water Balance by Renal Aquaporins |
| REACT_15295 | Opioid Signalling |
| REACT_13477 | Transmission across Chemical Synapses |
| REACT_18339 | Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
| REACT_15526 | G-protein mediated events |
| REACT_18274 | Regulation of Insulin Secretion by Glucagon-like Peptide-1 |
| REACT_15307 | Ca-dependent events |
| REACT_15312 | Adenylate cyclase activating pathway |
| REACT_25282 | Inhibition of adenylate cyclase pathway |
| REACT_25199 | GABA receptor activation |
| REACT_12056 | NGF signalling via TRKA from the plasma membrane |
| REACT_25031 | GABA B receptor activation |
| REACT_19231 | G alpha (i) signalling events |
| REACT_15426 | PLC beta mediated events |
| REACT_11061 | Signalling by NGF |
| REACT_1505 | Integration of energy metabolism |
| REACT_19184 | GPCR downstream signaling |
| REACT_15530 | PKA activation |
| REACT_9053 | CaM pathway |
| REACT_25330 | Activation of GABAB receptors |
| REACT_13685 | Synaptic Transmission |
| REACT_15518 | Transmembrane transport of small molecules |
| REACT_14797 | Signaling by GPCR |
| REACT_15370 | Neuroransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell |
| REACT_15497 | PKA-mediated phosphorylation of CREB |
| REACT_1946 | PKA activation in glucagon signalling |
| REACT_19327 | G alpha (s) signalling events |
| REACT_1665 | Glucagon signaling in metabolic regulation |
| Homo sapiens (human) | ADCY6 | NP_056085.1 |
| Pan troglodytes (chimpanzee) | ADCY6 | XP_509033.2 |
| Canis lupus familiaris (dog) | ADCY6 | XP_863249.1 |
| Bos taurus (cattle) | ADCY6 | XP_874732.2 |
| Mus musculus (house mouse) | Adcy6 | NP_031431.2 |
| Rattus norvegicus (Norway rat) | Adcy6 | NP_036953.2 |
| Danio rerio (zebrafish) | adcy6b | XP_002666536.1 |
| Danio rerio (zebrafish) | adcy6a | XP_001922749.1 |
| ID | Name | Evidence |
| GO:0006112 | energy reserve metabolic process | TAS |
| GO:0006833 | water transport | TAS |
| GO:0007189 | activation of adenylate cyclase activity by G-protein signaling pathway | EXP |
| GO:0007193 | inhibition of adenylate cyclase activity by G-protein signaling pathway | EXP |
| GO:0007202 | activation of phospholipase C activity | TAS |
| GO:0007268 | synaptic transmission | TAS |
| GO:0034199 | activation of protein kinase A activity | EXP |
| GO:0035556 | intracellular signal transduction | IEA |
| GO:0048011 | nerve growth factor receptor signaling pathway | TAS |
| GO:0055085 | transmembrane transport | TAS |
| GO:0071377 | cellular response to glucagon stimulus | EXP |
Component
| ID | Name | Evidence |
| GO:0005624 | membrane fraction | IEA |
| GO:0005768 | endosome | IEA |
| GO:0005886 | plasma membrane | EXP |
| GO:0005886 | plasma membrane | TAS |
| GO:0016021 | integral to membrane | IEA |
| GO:0031528 | microvillus membrane | IEA |
| GO:0042383 | sarcolemma | IEA |
| GO:0044424 | intracellular part | IEA |
| GO:0045121 | membrane raft | IEA |
Function
| ID | Name | Evidence |
| GO:0000166 | nucleotide binding | IEA |
| GO:0005102 | receptor binding | IEA |
| GO:0005515 | protein binding | IPI |
| GO:0005524 | ATP binding | IEA |
| GO:0008294 | calcium- and calmodulin-responsive adenylate cyclase activity | IEA |
| GO:0046872 | metal ion binding | IEA |
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