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ADCY6 adenylate cyclase 6 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_015270 Homo sapiens adenylate cyclase 6 (ADCY6), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
NM_020983 Homo sapiens adenylate cyclase 6 (ADCY6), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
XM_005268605 PREDICTED: Homo sapiens adenylate cyclase 6 (ADCY6), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
XM_006719209 PREDICTED: Homo sapiens adenylate cyclase 6 (ADCY6), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
XM_006719210 PREDICTED: Homo sapiens adenylate cyclase 6 (ADCY6), transcript variant X3, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
XM_006719211 PREDICTED: Homo sapiens adenylate cyclase 6 (ADCY6), transcript variant X4, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
XM_006719212 PREDICTED: Homo sapiens adenylate cyclase 6 (ADCY6), transcript variant X5, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
XM_006719213 PREDICTED: Homo sapiens adenylate cyclase 6 (ADCY6), transcript variant X6, mRNA. GenEZ ORF Cloning On-demand $1699.00 25

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Gene Symbol ADCY6
Entrez Gene ID 112
Full Name adenylate cyclase 6
Synonyms AC6
General protein information
Preferred Names
adenylate cyclase type 6
Names
adenylate cyclase type 6
adenylyl cyclase 6
ATP pyrophosphate-lyase 6
adenylate cyclase type VI
ca(2+)-inhibitable adenylyl cyclase
NP_056085.1
NP_066193.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

12

12q12-q13

Summary This gene encodes adenylate cyclase 6, which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). The expression of this gene is found in normal thyroid and brain tissues, as well as some tumors; and its expression is significantly higher in one hyperfunctioning thyroid tumor than in normal thyroid tissue. Alternative splicing generates 2 transcript variants. [provided by RefSeq, Jul 2008].
Disorder

MIM: 600294

mRNA Protein Product Sequence Price Select
NM_015270, 168480141 NP_056085, 10181096 adenylate cyclase type 6 isoform a ORF Sequence $1500.00
NM_020983, 21071019 NP_066193, 10947061 adenylate cyclase type 6 isoform b ORF Sequence $1500.00
XM_005268605, 530399673 XP_005268662, 530399674 adenylate cyclase type 6 isoform X1 ORF Sequence $1500.00
XM_006719209, 578823228 XP_006719272, 578823229 adenylate cyclase type 6 isoform X2 ORF Sequence $1500.00
XM_006719210, 578823230 XP_006719273, 578823231 adenylate cyclase type 6 isoform X3 ORF Sequence $1500.00
XM_006719211, 578823232 XP_006719274, 578823233 adenylate cyclase type 6 isoform X4 ORF Sequence $1500.00
XM_006719212, 578823234 XP_006719275, 578823235 adenylate cyclase type 6 isoform X5 ORF Sequence $1500.00
XM_006719213, 578823236 XP_006719276, 578823237 adenylate cyclase type 6 isoform X6 ORF Sequence $1500.00
KEGG
hsa00230Purine metabolism
hsa04742Taste transduction
hsa04916Melanogenesis
hsa04912GnRH signaling pathway
hsa04540Gap junction
hsa04062Chemokine signaling pathway
hsa04270Vascular smooth muscle contraction
hsa04914Progesterone-mediated oocyte maturation
hsa05414Dilated cardiomyopathy
hsa04962Vasopressin-regulated water reabsorption
hsa04114Oocyte meiosis
hsa04970Salivary secretion
hsa04971Gastric acid secretion
hsa04972Pancreatic secretion
hsa05166HTLV-I infection
hsa04961Endocrine and other factor-regulated calcium reabsorption
hsa04976Bile secretion
hsa04724Glutamatergic synapse
hsa04725Cholinergic synapse
hsa04727GABAergic synapse
hsa04723Retrograde endocannabinoid signaling
hsa04713Circadian entrainment
hsa04915Estrogen signaling pathway
hsa05032Morphine addiction
hsa04918Thyroid hormone synthesis
hsa04913Ovarian steroidogenesis
hsa04261Adrenergic signaling in cardiomyocytes
hsa04911Insulin secretion
hsa04750Inflammatory mediator regulation of TRP channels
hsa04921Oxytocin signaling pathway
hsa04611Platelet activation
hsa04015Rap1 signaling pathway
hsa04022cGMP-PKG signaling pathway
WikiPathways
WP289Myometrial Relaxation and Contraction Pathways
WP35G Protein Signaling Pathways
WP536Calcium Regulation in the Cardiac Cell
Pathway Interaction Database
lysophospholipid_pathwayLPA receptor mediated events
endothelinpathwayEndothelins
lpa4_pathwayLPA4-mediated signaling events
Reactome
REACT_19184GPCR downstream signaling
REACT_19327G alpha (s) signalling events
REACT_19231G alpha (i) signalling events
REACT_19333G alpha (z) signalling events
REACT_18339Adrenaline,noradrenaline inhibits insulin secretion
REACT_18274Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
REACT_18325Regulation of insulin secretion
REACT_1505Integration of energy metabolism
REACT_1665Glucagon signaling in metabolic regulation
REACT_1946PKA activation in glucagon signalling
REACT_12478EGFR interacts with phospholipase C-gamma
REACT_9470Signaling by FGFR
REACT_14797Signaling by GPCR
REACT_9417Signaling by EGFR
REACT_16888Signaling by PDGF
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_17025Downstream signal transduction
REACT_11061Signalling by NGF
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_9053CaM pathway
REACT_15530PKA activation
REACT_15497PKA-mediated phosphorylation of CREB
REACT_15295Opioid Signalling
REACT_15526G-protein mediated events
REACT_12079PLC-gamma1 signalling
REACT_15426PLC beta mediated events
REACT_15370Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
REACT_9000Calmodulin induced events
REACT_15518Transmembrane transport of small molecules
REACT_15307Ca-dependent events
REACT_13477Transmission across Chemical Synapses
REACT_15312Adenylate cyclase activating pathway
REACT_15333Adenylate cyclase inhibitory pathway
REACT_13685Neuronal System
REACT_21272Downstream signaling of activated FGFR
REACT_21310Phospholipase C-mediated cascade
REACT_25031GABA B receptor activation
REACT_25330Activation of GABAB receptors
REACT_25199GABA receptor activation
REACT_25282Inhibition of adenylate cyclase pathway
REACT_24023Regulation of water balance by renal Aquaporins
REACT_23887Aquaporin-mediated transport
REACT_111102Signal Transduction
REACT_111064DAG and IP3 signaling
REACT_111217Metabolism
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_115755Signaling by ERBB2
REACT_116125Disease
REACT_115720PLCG1 events in ERBB2 signaling
REACT_115871Signaling by EGFR in Cancer
REACT_120736Signaling by FGFR in disease
Homo sapiens (human)ADCY6NP_056085.1
Pan troglodytes (chimpanzee)ADCY6XP_509033.3
Macaca mulatta (Rhesus monkey)ADCY6XP_001102486.1
Canis lupus familiaris (dog)ADCY6NP_001182076.1
Bos taurus (cattle)ADCY6NP_001137349.1
Mus musculus (house mouse)Adcy6NP_031431.2
Rattus norvegicus (Norway rat)Adcy6NP_001257714.1
Danio rerio (zebrafish)adcy6bXP_002666536.2
Xenopus (Silurana) tropicalis (western clawed frog)adcy6XP_002935166.2
Process
IDNameEvidence
GO:0006112energy reserve metabolic processTAS
GO:0006171cAMP biosynthetic processIDA
GO:0006833water transportTAS
GO:0007165signal transductionTAS
GO:0007173epidermal growth factor receptor signaling pathwayTAS
GO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathwayTAS
GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwayTAS
GO:0007202activation of phospholipase C activityTAS
GO:0007212dopamine receptor signaling pathwayIDA
GO:0007268synaptic transmissionTAS
GO:0008543fibroblast growth factor receptor signaling pathwayTAS
GO:0010977negative regulation of neuron projection developmentISS
GO:0034199activation of protein kinase A activityTAS
GO:0035556intracellular signal transductionIEA
GO:0044281small molecule metabolic processTAS
GO:0045087innate immune responseTAS
GO:0048011neurotrophin TRK receptor signaling pathwayTAS
GO:0055085transmembrane transportTAS
GO:0071377cellular response to glucagon stimulusTAS
GO:0071380cellular response to prostaglandin E stimulusIDA
GO:0071870cellular response to catecholamine stimulusIDA
Component
IDNameEvidence
GO:0005886plasma membraneTAS
GO:0005929ciliumIEA
GO:0016020membraneISS
GO:0016021integral component of membraneIEA
Function
IDNameEvidence
GO:0004016adenylate cyclase activityIDA
GO:0005515protein bindingIPI
GO:0005524ATP bindingIEA
GO:0019901protein kinase bindingISS
GO:0046872metal ion bindingIEA
GeneCards ADCY6
UniProt O43306
Vega OTTHUMG00000170396
MIM 600294
Ensembl ENSG00000174233
HGNC 237
HPRD 02621

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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