CHKB choline kinase beta [Homo sapiens (human)]
| Gene Symbol | CHKB |
| Entrez Gene ID | 1120 |
| Full Name | choline kinase beta |
| Synonyms | CHETK, CHKL, CK, CKB, CKEKB, EK, EKB |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
22 22q13.33 |
| Summary | Choline kinase (CK) and ethanolamine kinase (EK) catalyze the phosphorylation of choline/ethanolamine to phosphocholine/phosphoethanolamine. This is the first enzyme in the biosynthesis of phosphatidylcholine/phosphatidylethanolamine in all animal cells. The highly purified CKs from mammalian sources and their recombinant gene products have been shown to have EK activity also, indicating that both activities reside on the same protein. The choline kinase-like protein encoded by CHKL belongs to the choline/ethanolamine kinase family; however, its exact function is not known. Read-through transcripts are expressed from this locus that include exons from the downstream CPT1B locus. [provided by RefSeq]. COMPLETENESS: complete on the 3' end. |
| Disorder | MIM: 612395 |
| mRNA | NM_005198, 242246959 |
| Protein | NP_005189, 6978649 |
| Product | choline/ethanolamine kinase |
| RefSeq Status | REVIEWED |
| hsa00564 | Glycerophospholipid metabolism |
| hsa01100 | Metabolic pathways |
WikiPathways
| WP1403 | AMPK signaling |
| WP143 | Fatty Acid Beta Oxidation |
| Homo sapiens (human) | CHKB | NP_005189.2 |
| Pan troglodytes (chimpanzee) | CHKB | XP_001144399.1 |
| Canis lupus familiaris (dog) | CHKB | XP_848257.1 |
| Bos taurus (cattle) | CHKB | XP_616335.2 |
| Mus musculus (house mouse) | Chkb | NP_031718.1 |
| Rattus norvegicus (Norway rat) | Chkb | NP_058873.1 |
| Danio rerio (zebrafish) | chkb | NP_001093482.1 |
| Drosophila melanogaster (fruit fly) | CG2201 | NP_724349.1 |
| Caenorhabditis elegans | cka-2 | NP_001024480.1 |
| Arabidopsis thaliana (thale cress) | ATCK1 | NP_177315.1 |
| Arabidopsis thaliana (thale cress) | AT4G09760 | NP_192714.1 |
| ID | Name | Evidence |
| GO:0006646 | phosphatidylethanolamine biosynthetic process | IDA |
| GO:0006657 | CDP-choline pathway | IDA |
| GO:0008654 | phospholipid biosynthetic process | IEA |
Function
| ID | Name | Evidence |
| GO:0000166 | nucleotide binding | IEA |
| GO:0004103 | choline kinase activity | IDA |
| GO:0004305 | ethanolamine kinase activity | IDA |
| GO:0005524 | ATP binding | IEA |
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