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CHKB choline kinase beta [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_005198 Homo sapiens choline kinase beta (CHKB), mRNA. GenEZ ORF Cloning In-stock $418.00 $369.00 10

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Gene Symbol CHKB
Entrez Gene ID 1120
Full Name choline kinase beta
Synonyms CHETK, CHKL, CK, CKB, CKEKB, EK, EKB, MDCMC
General protein information
Preferred Names
choline/ethanolamine kinase
Names
choline/ethanolamine kinase
ethanolamine kinase beta
choline kinase-like protein
NP_005189.2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

22

22q13.33

Summary Choline kinase (CK) and ethanolamine kinase (EK) catalyze the phosphorylation of choline/ethanolamine to phosphocholine/phosphoethanolamine. This is the first enzyme in the biosynthesis of phosphatidylcholine/phosphatidylethanolamine in all animal cells. The highly purified CKs from mammalian sources and their recombinant gene products have been shown to have EK activity also, indicating that both activities reside on the same protein. The choline kinase-like protein encoded by CHKL belongs to the choline/ethanolamine kinase family; however, its exact function is not known. Read-through transcripts are expressed from this locus that include exons from the downstream CPT1B locus. [provided by RefSeq, Jun 2009].
Disorder

MIM: 612395

mRNA Protein Product Sequence Price Select
NM_005198, 242246959 NP_005189, 6978649 choline/ethanolamine kinase ORF Sequence $269.00
KEGG
hsa00564Glycerophospholipid metabolism
hsa_M00092Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE
hsa_M00090Phosphatidylcholine (PC) biosynthesis, choline => PC
WikiPathways
WP143Fatty Acid Beta Oxidation
Reactome
REACT_22258Metabolism of lipids and lipoproteins
REACT_111217Metabolism
REACT_121401Glycerophospholipid biosynthesis
REACT_120870Phospholipid metabolism
REACT_121238Synthesis of PC
REACT_120919Synthesis of PE
Homo sapiens (human)CHKBNP_005189.2
Pan troglodytes (chimpanzee)CHKBXP_001144556.1
Macaca mulatta (Rhesus monkey)LOC716377XP_002808018.1
Canis lupus familiaris (dog)CHKBXP_848257.1
Bos taurus (cattle)CHKBNP_001193023.1
Mus musculus (house mouse)ChkbNP_031718.1
Rattus norvegicus (Norway rat)ChkbNP_058873.1
Danio rerio (zebrafish)chkbNP_001093482.1
Drosophila melanogaster (fruit fly)CG2201NP_724349.1
Caenorhabditis eleganscka-1NP_001129849.1
Arabidopsis thaliana (thale cress)AT1G74320NP_177572.2
Xenopus (Silurana) tropicalis (western clawed frog)chkbNP_001120148.1
Process
IDNameEvidence
GO:0006644phospholipid metabolic processTAS
GO:0006646phosphatidylethanolamine biosynthetic processIDA
GO:0006646phosphatidylethanolamine biosynthetic processIEA
GO:0006646phosphatidylethanolamine biosynthetic processTAS
GO:0006656phosphatidylcholine biosynthetic processTAS
GO:0006657CDP-choline pathwayIDA
GO:0006657CDP-choline pathwayIEA
GO:0016310phosphorylationIEA
GO:0044281small molecule metabolic processTAS
GO:0046474glycerophospholipid biosynthetic processTAS
Component
IDNameEvidence
GO:0005829cytosolTAS
Function
IDNameEvidence
GO:0004103choline kinase activityIDA
GO:0004305ethanolamine kinase activityIDA
GO:0005524ATP bindingIEA
GeneCards CHKB
UniProt Q9Y259
Vega OTTHUMG00000150275
MIM 612395
Ensembl ENSG00000100288
HGNC 1938
HPRD 07631

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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