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CHKB choline kinase beta [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_005198 Homo sapiens choline kinase beta (CHKB), mRNA. ORF Sequence $344.52
Peptide Services
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Gene Symbol CHKB
Entrez Gene ID 1120
Full Name choline kinase beta
Synonyms CHETK, CHKL, CK, CKB, CKEKB, EK, EKB
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

22

22q13.33

Summary Choline kinase (CK) and ethanolamine kinase (EK) catalyze the phosphorylation of choline/ethanolamine to phosphocholine/phosphoethanolamine. This is the first enzyme in the biosynthesis of phosphatidylcholine/phosphatidylethanolamine in all animal cells. The highly purified CKs from mammalian sources and their recombinant gene products have been shown to have EK activity also, indicating that both activities reside on the same protein. The choline kinase-like protein encoded by CHKL belongs to the choline/ethanolamine kinase family; however, its exact function is not known. Read-through transcripts are expressed from this locus that include exons from the downstream CPT1B locus. [provided by RefSeq, Jun 2009].
Disorder

MIM: 612395

mRNA Protein Product Sequence Price Select
NM_005198, 242246959 NP_005189, 6978649 choline/ethanolamine kinase Full Length $477.92
ORF Sequence $344.52
KEGG
hsa_M00092Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE
hsa00564Glycerophospholipid metabolism
hsa_M00090Phosphatidylcholine (PC) biosynthesis, choline => PC
WikiPathways
WP143Fatty Acid Beta Oxidation
Reactome
REACT_22258Metabolism of lipids and lipoproteins
REACT_120919Synthesis of PE
REACT_121401Glycerophospholipid biosynthesis
REACT_111217Metabolism
REACT_120870Phospholipid metabolism
REACT_121238Synthesis of PC
Homo sapiens (human)CHKBNP_005189.2
Pan troglodytes (chimpanzee)CHKBXP_001144556.1
Macaca mulatta (Rhesus monkey)LOC716377XP_002808018.1
Canis lupus familiaris (dog)CHKBXP_848257.1
Bos taurus (cattle)CHKBNP_001193023.1
Mus musculus (house mouse)ChkbNP_031718.1
Rattus norvegicus (Norway rat)ChkbNP_058873.1
Danio rerio (zebrafish)chkbNP_001093482.1
Drosophila melanogaster (fruit fly)CG2201NP_724349.1
Caenorhabditis eleganscka-2NP_001024480.1
Arabidopsis thaliana (thale cress)CK1NP_177315.1
Arabidopsis thaliana (thale cress)AT4G09760NP_192714.1
GeneCards CHKB
PDB 3LQ3, 2IG7, 3FEG
UniProt Q9Y259
MIM 612395
Ensembl ENSG00000205560
HGNC 1938
HPRD 07631

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
choline/ethanolamine kinase
Names
choline/ethanolamine kinase
ethanolamine kinase beta
choline kinase-like protein
NP_005189.2

Interactant

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