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POU6F2 POU class 6 homeobox 2 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu12453 NM_001166018 Homo sapiens POU class 6 homeobox 2 (POU6F2), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand TBD TBD
OHu22269 NM_007252 Homo sapiens POU class 6 homeobox 2 (POU6F2), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand TBD TBD
OHu12453C NM_001166018 Homo sapiens POU class 6 homeobox 2 (POU6F2), transcript variant 2, mRNA. Customized vector On-demand TBD $269.00
OHu22269C NM_007252 Homo sapiens POU class 6 homeobox 2 (POU6F2), transcript variant 1, mRNA. Customized vector On-demand TBD $329.00

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Gene Symbol POU6F2
Entrez Gene ID 11281
Full Name POU class 6 homeobox 2
Synonyms RPF-1, WT5, WTSL
General protein information
Preferred Names
POU domain, class 6, transcription factor 2
Names
POU domain, class 6, transcription factor 2
Wilms tumor suppressor locus
retina-derived POU domain factor 1
retina-derived POU-domain factor-1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

7

7p14.1

Summary This gene encodes a member of the POU protein family characterized by the presence of a bipartite DNA binding domain, consisting of a POU-specific domain and a homeodomain, separated by a variable polylinker. The DNA binding domain may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. The POU family members are transcriptional regulators, many of which are known to control cell type-specific differentiation pathways. This gene is a tumor suppressor involved in Wilms tumor (WT) predisposition. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Oct 2009].
Disorder

MIM: 609062

{Wilms tumor susceptibility-5}, 601583 (3)

mRNA Protein Product Sequence Price Select
NM_001166018, 260436857 NP_001159490, 260436858 POU domain, class 6, transcription factor 2 isoform 2 ORF Sequence $700.00
NM_007252, 260436856 NP_009183, 157743257 POU domain, class 6, transcription factor 2 isoform 1 ORF Sequence $700.00
Homo sapiens (human)POU6F2NP_009183.3
Macaca mulatta (Rhesus monkey)POU6F2XP_001100998.2
Canis lupus familiaris (dog)POU6F2XP_540368.4
Process
IDNameEvidence
GO:0006355regulation of transcription, DNA-templatedTAS
GO:0006366transcription from RNA polymerase II promoterTAS
GO:0007402ganglion mother cell fate determinationTAS
GO:0007417central nervous system developmentTAS
GO:0007601visual perceptionTAS
Component
IDNameEvidence
GO:0005634nucleusIC
Function
IDNameEvidence
GO:0003700sequence-specific DNA binding transcription factor activityTAS
GO:0043565sequence-specific DNA bindingIEA
GeneCards POU6F2
UniProt P78424
Vega OTTHUMG00000150803
MIM 609062
Ensembl ENSG00000106536
HGNC 21694
HPRD 10162

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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