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PARK7 parkinson protein 7 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu26877 NM_001123377 Homo sapiens parkinson protein 7 (PARK7), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu26877 NM_007262 Homo sapiens parkinson protein 7 (PARK7), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu26877 XM_005263424 PREDICTED: Homo sapiens parkinson protein 7 (PARK7), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu26877C NM_001123377 Homo sapiens parkinson protein 7 (PARK7), transcript variant 2, mRNA. Customized vector On-demand 7-9 $209.00
OHu26877C NM_007262 Homo sapiens parkinson protein 7 (PARK7), transcript variant 1, mRNA. Customized vector On-demand 7-9 $209.00
OHu26877C XM_005263424 PREDICTED: Homo sapiens parkinson protein 7 (PARK7), transcript variant X1, mRNA. Customized vector On-demand 7-9 $209.00

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Gene Symbol PARK7
Entrez Gene ID 11315
Full Name parkinson protein 7
Synonyms DJ-1, DJ1, HEL-S-67p
General protein information
Preferred Names
protein DJ-1
Names
protein DJ-1
oncogene DJ1
Parkinson disease (autosomal recessive, early onset) 7
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1p36.23

Summary The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008].
Disorder

MIM: 602533

Parkinson disease 7, autosomal recessive early-onset, 606324 (3);

mRNA Protein Product Sequence Price Select
NM_001123377, 183227677 NP_001116849, 183227678 protein DJ-1 ORF Sequence $250.00
NM_007262, 183227676 NP_009193, 31543380 protein DJ-1 ORF Sequence $250.00
XM_005263424, 530360486 XP_005263481, 530360487 protein DJ-1 isoform X1 ORF Sequence $250.00
KEGG
hsa05012Parkinson's disease
WikiPathways
WP138Androgen receptor signaling pathway
WP2371Parkinsons Disease Pathway
WP2267Synaptic Vesicle Pathway
Pathway Interaction Database
alphasynuclein_pathwayAlpha-synuclein signaling
Homo sapiens (human)PARK7NP_009193.2
Canis lupus familiaris (dog)PARK7XP_859031.1
Bos taurus (cattle)PARK7NP_001015572.1
Mus musculus (house mouse)Park7NP_065594.2
Rattus norvegicus (Norway rat)Park7NP_001264180.1
Gallus gallus (chicken)PARK7NP_989916.1
Danio rerio (zebrafish)park7NP_001005938.1
Drosophila melanogaster (fruit fly)dj-1betaNP_651825.3
Drosophila melanogaster (fruit fly)DJ-1alphaNP_610916.1
Caenorhabditis elegansdjr-1.1NP_493696.1
Caenorhabditis elegansdjr-1.2NP_504132.1
Arabidopsis thaliana (thale cress)AT3G14990NP_188117.1
Arabidopsis thaliana (thale cress)AT1G53280NP_564626.1
Xenopus (Silurana) tropicalis (western clawed frog)park7NP_001015851.1
Process
IDNameEvidence
GO:0001933negative regulation of protein phosphorylationIGI
GO:0006469negative regulation of protein kinase activityIGI
GO:0006508proteolysisIEA
GO:0006914autophagyIEA
GO:0006954inflammatory responseIEA
GO:0007005mitochondrion organizationISS
GO:0007338single fertilizationIEA
GO:0008344adult locomotory behaviorIEA
GO:0010629negative regulation of gene expressionIDA
GO:0032091negative regulation of protein bindingIDA
GO:0032091negative regulation of protein bindingIGI
GO:0032091negative regulation of protein bindingIMP
GO:0032757positive regulation of interleukin-8 productionIDA
GO:0034599cellular response to oxidative stressIDA
GO:0042743hydrogen peroxide metabolic processIDA
GO:0043523regulation of neuron apoptotic processIDA
GO:0043524negative regulation of neuron apoptotic processIDA
GO:0045560regulation of TRAIL receptor biosynthetic processIMP
GO:0045944positive regulation of transcription from RNA polymerase II promoterIDA
GO:0046826negative regulation of protein export from nucleusIGI
GO:0050727regulation of inflammatory responseISS
GO:0050821protein stabilizationIDA
GO:0050821protein stabilizationIMP
GO:0051583dopamine uptake involved in synaptic transmissionIEA
GO:0051881regulation of mitochondrial membrane potentialIMP
GO:0051899membrane depolarizationIEA
GO:0055114oxidation-reduction processIDA
GO:0055114oxidation-reduction processIEA
GO:0060081membrane hyperpolarizationIEA
GO:0060548negative regulation of cell deathIDA
GO:0060765regulation of androgen receptor signaling pathwayIDA
GO:0070301cellular response to hydrogen peroxideIDA
GO:0090073positive regulation of protein homodimerization activityIDA
GO:1900182positive regulation of protein localization to nucleusIDA
GO:1901215negative regulation of neuron deathIDA
GO:1901299negative regulation of hydrogen peroxide-mediated programmed cell deathIDA
GO:1901671positive regulation of superoxide dismutase activityIDA
GO:1901984negative regulation of protein acetylationIDA
GO:1903073negative regulation of death-inducing signaling complex assemblyIC
GO:1903094negative regulation of protein K48-linked deubiquitinationIDA
GO:1903122negative regulation of TRAIL-activated apoptotic signaling pathwayIMP
GO:2000157negative regulation of ubiquitin-specific protease activityIDA
GO:2000277positive regulation of oxidative phosphorylation uncoupler activityIEA
GO:2000825positive regulation of androgen receptor activityIMP
GO:2001237negative regulation of extrinsic apoptotic signaling pathwayIMP
GO:2001268negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwayIMP
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005737cytoplasmIDA
GO:0005739mitochondrionIDA
GO:0005739mitochondrionIMP
GO:0005829cytosolIDA
GO:0005829cytosolIMP
GO:0005886plasma membraneIEA
GO:0016605PML bodyIDA
GO:0045121membrane raftIEA
GO:0070062extracellular vesicular exosomeIDA
Function
IDNameEvidence
GO:0003690double-stranded DNA bindingIDA
GO:0003697single-stranded DNA bindingIDA
GO:0003729mRNA bindingIDA
GO:0004601peroxidase activityIEA
GO:0005102receptor bindingIPI
GO:0005515protein bindingIPI
GO:0008134transcription factor bindingIPI
GO:0008233peptidase activityIDA
GO:0016532superoxide dismutase copper chaperone activityIDA
GO:0016684oxidoreductase activity, acting on peroxide as acceptorIDA
GO:0019899enzyme bindingIPI
GO:0019955cytokine bindingIPI
GO:0042802identical protein bindingIPI
GO:0042803protein homodimerization activityIDA
GO:0044388small protein activating enzyme bindingIPI
GO:0044390small protein conjugating enzyme bindingIPI
GO:0050681androgen receptor bindingIPI
GO:0051920peroxiredoxin activityIEA
GO:0097110scaffold protein bindingIPI
GO:1903135cupric ion bindingIDA
GO:1903136cuprous ion bindingIDA
GO:1990381ubiquitin-specific protease bindingIPI
GeneCards PARK7
PDB 1UCF, 3EZG, 1SOA, 3CZ9, 4MNT, 3B3A, 1Q2U, 1PDW, 1J42, 4N0M, 4P36, 1PDV, 2R1T, 2RK6, 2RK3, 4OQ4, 3CY6, 1P5F, 2OR3, 4P35, 2R1U, 3BWE, 2R1V, 4P2G, 3B36, 3SF8, 2RK4, 3B38, 3CZA, 3CYF, 4BTE, 1PE0, 4MTC, 4P34, 4N12, 3F71
UniProt V9HWC2, Q99497
Vega OTTHUMG00000001210
MIM 602533
Ensembl ENSG00000116288
HGNC 16369
HPRD 03961

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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