PARK7 Parkinson disease (autosomal recessive, early onset) 7 [Homo sapiens (human)]
| Gene Symbol | PARK7 |
| Entrez Gene ID | 11315 |
| Full Name | Parkinson disease (autosomal recessive, early onset) 7 |
| Synonyms | DJ-1, DJ1, FLJ27376, FLJ34360, FLJ92274 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
1 1p36.23 |
| Summary | The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq]. |
| Disorder | MIM: 602533 Parkinson disease 7, autosomal recessive early-onset, 606324 (3); |
| mRNA | NM_007262, 183227676 |
| Protein | NP_009193, 31543380 |
| Product | protein DJ-1 |
| RefSeq Status | REVIEWED |
| mRNA | NM_001123377, 183227677 |
| Protein | NP_001116849, 183227678 |
| Product | protein DJ-1 |
| RefSeq Status | REVIEWED |
| hsa05012 | Parkinson's disease |
Pathway Interaction Database
| alphasynuclein_pathway | Alpha-synuclein signaling |
| Homo sapiens (human) | PARK7 | NP_001116849.1 |
| Pan troglodytes (chimpanzee) | PARK7 | XP_001158093.1 |
| Canis lupus familiaris (dog) | PARK7 | XP_536733.1 |
| Bos taurus (cattle) | PARK7 | NP_001015572.1 |
| Mus musculus (house mouse) | Park7 | NP_065594.2 |
| Rattus norvegicus (Norway rat) | Park7 | NP_476484.1 |
| Gallus gallus (chicken) | PARK7 | NP_989916.1 |
| Danio rerio (zebrafish) | park7 | NP_001005938.1 |
| Drosophila melanogaster (fruit fly) | dj-1beta | NP_651825.3 |
| Drosophila melanogaster (fruit fly) | DJ-1alpha | NP_610916.1 |
| Caenorhabditis elegans | djr-1.1 | NP_493696.1 |
| Caenorhabditis elegans | djr-1.2 | NP_504132.1 |
| ID | Name | Evidence |
| GO:0006914 | autophagy | IEA |
| GO:0007005 | mitochondrion organization | ISS |
| GO:0007338 | single fertilization | IEA |
| GO:0008344 | adult locomotory behavior | IEA |
| GO:0032091 | negative regulation of protein binding | IDA |
| GO:0034599 | cellular response to oxidative stress | IEA |
| GO:0042493 | response to drug | IEA |
| GO:0042743 | hydrogen peroxide metabolic process | IEA |
| GO:0043526 | neuroprotection | IDA |
| GO:0050727 | regulation of inflammatory response | ISS |
| GO:0050821 | protein stabilization | IMP |
| GO:0051583 | dopamine uptake | IEA |
| GO:0051899 | membrane depolarization | IEA |
| GO:0060081 | membrane hyperpolarization | IEA |
| GO:0060548 | negative regulation of cell death | IDA |
| GO:0060765 | regulation of androgen receptor signaling pathway | IDA |
| GO:0070301 | cellular response to hydrogen peroxide | IDA |
| GO:2000277 | positive regulation of oxidative phosphorylation uncoupler activity | IEA |
Component
| ID | Name | Evidence |
| GO:0005634 | nucleus | IDA |
| GO:0005737 | cytoplasm | IDA |
| GO:0005739 | mitochondrion | IDA |
| GO:0005829 | cytosol | IEA |
| GO:0030424 | axon | IEA |
Function
| ID | Name | Evidence |
| GO:0003729 | mRNA binding | IDA |
| GO:0004601 | peroxidase activity | ISS |
| GO:0005515 | protein binding | IPI |
| GO:0008233 | peptidase activity | IDA |
| GO:0042803 | protein homodimerization activity | IDA |
| GO:0051920 | peroxiredoxin activity | IEA |
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