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CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000079 Homo sapiens cholinergic receptor, nicotinic, alpha 1 (muscle) (CHRNA1), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_001039523 Homo sapiens cholinergic receptor, nicotinic, alpha 1 (muscle) (CHRNA1), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $699.00 18

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Gene Symbol CHRNA1
Entrez Gene ID 1134
Full Name cholinergic receptor, nicotinic, alpha 1 (muscle)
Synonyms ACHRA, ACHRD, CHRNA, CMS2A, FCCMS, SCCMS
General protein information
Preferred Names
acetylcholine receptor subunit alpha
Names
acetylcholine receptor subunit alpha
nicotinic cholinergic receptor alpha 1
muscle nicotinic acetylcholine receptor
nicotinic acetylcholine receptor alpha subunit
acetylcholine receptor, nicotinic, alpha 1 (muscle)
cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

2

2q31.1

Summary The muscle acetylcholine receptor consiststs of 5 subunits of 4 different types: 2 alpha subunits and 1 each of the beta, gamma, and delta subunits. This gene encodes an alpha subunit that plays a role in acetlycholine binding/channel gating. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Nov 2012].
Disorder

MIM: 100690

Myasthenic syndrome, slow-channel congenital, 601462 (3);

mRNA Protein Product Sequence Price Select
NM_000079, 189571659 NP_000070, 4557457 acetylcholine receptor subunit alpha isoform b precursor ORF Sequence $550.00
NM_001039523, 189571658 NP_001034612, 87567783 acetylcholine receptor subunit alpha isoform a precursor ORF Sequence $550.00
KEGG
hsa04080Neuroactive ligand-receptor interaction
Pathway Interaction Database
erbb2erbb3pathwayErbB2/ErbB3 signaling events
botulinumtoxinpathwayEffects of Botulinum toxin
Reactome
REACT_15370Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
REACT_13477Transmission across Chemical Synapses
REACT_15461Acetylcholine Binding And Downstream Events
REACT_13685Neuronal System
REACT_22149Postsynaptic nicotinic acetylcholine receptors
REACT_22303Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
REACT_22126Activation of Nicotinic Acetylcholine Receptors
REACT_22336Presynaptic nicotinic acetylcholine receptors
REACT_22352Highly calcium permeable nicotinic acetylcholine receptors
Homo sapiens (human)CHRNA1NP_001034612.1
Pan troglodytes (chimpanzee)CHRNA1XP_003309365.1
Macaca mulatta (Rhesus monkey)CHRNA1XP_001091711.1
Canis lupus familiaris (dog)CHRNA1NP_001003144.1
Bos taurus (cattle)CHRNA1NP_788837.1
Mus musculus (house mouse)Chrna1NP_031415.2
Rattus norvegicus (Norway rat)Chrna1NP_077811.1
Gallus gallus (chicken)CHRNA1NP_990147.1
Danio rerio (zebrafish)chrna1NP_571520.1
Xenopus (Silurana) tropicalis (western clawed frog)chrna1XP_002934647.1
Process
IDNameEvidence
GO:0003009skeletal muscle contractionIMP
GO:0006810transportTAS
GO:0006812cation transportIEA
GO:0006812cation transportIMP
GO:0006812cation transportISS
GO:0006812cation transportTAS
GO:0007165signal transductionTAS
GO:0007268synaptic transmissionTAS
GO:0007274neuromuscular synaptic transmissionIMP
GO:0007528neuromuscular junction developmentIMP
GO:0019228neuronal action potentialIMP
GO:0034220ion transmembrane transportIEA
GO:0034220ion transmembrane transportTAS
GO:0042391regulation of membrane potentialIMP
GO:0046716muscle cell cellular homeostasisIMP
GO:0048630skeletal muscle tissue growthIMP
GO:0050881musculoskeletal movementIMP
GO:0050905neuromuscular processIMP
GO:0070050neuron cellular homeostasisIMP
Component
IDNameEvidence
GO:0005886plasma membraneISS
GO:0005886plasma membraneTAS
GO:0005892acetylcholine-gated channel complexISS
GO:0009986cell surfaceIDA
GO:0030054cell junctionIEA
GO:0031594neuromuscular junctionIDA
GO:0031594neuromuscular junctionISS
GO:0045211postsynaptic membraneNAS
Function
IDNameEvidence
GO:0004889acetylcholine-activated cation-selective channel activityIMP
GO:0004889acetylcholine-activated cation-selective channel activityISS
GO:0005216ion channel activityTAS
GO:0015464acetylcholine receptor activityISS
GO:0042166acetylcholine bindingISS
GeneCards CHRNA1
UniProt Q53SH4, P02708
Vega OTTHUMG00000132357
MIM 100690
Ensembl ENSG00000138435
HGNC 1955
HPRD 00007

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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