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Sequence in raw or FASTA format:

Database:

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CHRNE cholinergic receptor, nicotinic, epsilon [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_000080 Homo sapiens cholinergic receptor, nicotinic, epsilon (muscle) (CHRNE), mRNA. ORF Sequence $429.78
Peptide Services
Antibody Services
Protein Services


Gene Symbol CHRNE
Entrez Gene ID 1145
Full Name cholinergic receptor, nicotinic, epsilon
Synonyms ACHRE, CMS1D, CMS1E, CMS2A, FCCMS, SCCMS
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

17

17p13.2

Summary Acetylcholine receptors at mature mammalian neuromuscular junctions are pentameric protein complexes composed of four subunits in the ratio of two alpha subunits to one beta, one epsilon, and one delta subunit. The acetylcholine receptor changes subunit composition shortly after birth when the epsilon subunit replaces the gamma subunit seen in embryonic receptors. Mutations in the epsilon subunit are associated with congenital myasthenic syndrome. [provided by RefSeq, Sep 2009].
Disorder

MIM: 100725

Myasthenic syndrome, slow-channel congenital, 601462 (3);

mRNA Protein Product Sequence Price Select
NM_000080, 294862246 NP_000071, 4557463 acetylcholine receptor subunit epsilon precursor Full Length $713.40
ORF Sequence $429.78
KEGG
hsa04080Neuroactive ligand-receptor interaction
Pathway Interaction Database
erbb2erbb3pathwayErbB2/ErbB3 signaling events
Reactome
REACT_15370Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
REACT_22223Highly sodium permeable acetylcholine nicotinic receptors
REACT_13477Transmission across Chemical Synapses
REACT_15461Acetylcholine Binding And Downstream Events
REACT_22336Presynaptic nicotinic acetylcholine receptors
REACT_22126Activation of Nicotinic Acetylcholine Receptors
REACT_22149Postsynaptic nicotinic acetylcholine receptors
REACT_13685Neuronal System
Homo sapiens (human)CHRNENP_000071.1
Pan troglodytes (chimpanzee)CHRNEXP_523556.4
Macaca mulatta (Rhesus monkey)CHRNEXP_001097094.1
Canis lupus familiaris (dog)CHRNEXP_536608.3
Bos taurus (cattle)CHRNENP_776697.1
Mus musculus (house mouse)ChrneNP_033733.1
Rattus norvegicus (Norway rat)ChrneNP_058890.1
GeneCards CHRNE
PDB 2DF9
UniProt Q04844
MIM 100725
Ensembl ENSG00000108556
HGNC 1966
HPRD 00008

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
acetylcholine receptor subunit epsilon
Names
acetylcholine receptor subunit epsilon
AchR epsilon subunit
acetylcholine receptor, nicotinic, epsilon (muscle)
cholinergic receptor, nicotinic, epsilon polypeptide

Interactant

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