CKM creatine kinase, muscle [Homo sapiens (human)]
| Gene Symbol | CKM |
| Entrez Gene ID | 1158 |
| Full Name | creatine kinase, muscle |
| Synonyms | CKMM, M-CK |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
19 19q13.2-q13.3 |
| Summary | The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis and is an important serum marker for myocardial infarction. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in striated muscle as well as in other tissues, and as a heterodimer with a similar brain isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. [provided by RefSeq]. |
| Disorder | MIM: 123310 |
| mRNA | NM_001824, 299473751 |
| Protein | NP_001815, 21536288 |
| Product | creatine kinase M-type |
| RefSeq Status | REVIEWED |
| hsa01100 | Metabolic pathways |
| hsa00330 | Arginine and proline metabolism |
Pathway Interaction Database
| rb_1pathway | Regulation of retinoblastoma protein |
WikiPathways
| WP497 | Urea cycle and metabolism of amino groups |
BIOCYC
| META_PWY-6158 | creatine-phosphate biosynthesis |
Reactome
| REACT_13 | Metabolism of amino acids and derivatives |
| REACT_813 | Creatine metabolism |
| Homo sapiens (human) | CKM | NP_001815.2 |
| Pan troglodytes (chimpanzee) | CKM | XP_001163660.1 |
| Canis lupus familiaris (dog) | CKM | XP_533641.2 |
| Bos taurus (cattle) | CKM | NP_777198.2 |
| Mus musculus (house mouse) | Ckm | NP_031736.1 |
| Rattus norvegicus (Norway rat) | Ckm | NP_036662.1 |
| Danio rerio (zebrafish) | ckmb | NP_001099153.1 |
| Danio rerio (zebrafish) | ckma | NP_571007.1 |
| ID | Name | Evidence |
| GO:0006600 | creatine metabolic process | EXP |
| GO:0034641 | cellular nitrogen compound metabolic process | TAS |
| GO:0046314 | phosphocreatine biosynthetic process | IEA |
Component
| ID | Name | Evidence |
| GO:0005737 | cytoplasm | NAS |
| GO:0005829 | cytosol | EXP |
Function
| ID | Name | Evidence |
| GO:0000166 | nucleotide binding | IEA |
| GO:0004111 | creatine kinase activity | IEA |
| GO:0005524 | ATP binding | IEA |
Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.
 |
Secured Online Quotation |
 |
Email: gene@genscript.com |
 |
Phone: 1-877-436-7274 (Toll-Free) 1-732-885-9188 |
 |
Fax: 1-732-210-0262 1-732-885-5878 |