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ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary) [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu16639 NM_001099733 Homo sapiens adenylate cyclase activating polypeptide 1 (pituitary) (ADCYAP1), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu16639 NM_001117 Homo sapiens adenylate cyclase activating polypeptide 1 (pituitary) (ADCYAP1), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu50973 XM_005258081 PREDICTED: Homo sapiens adenylate cyclase activating polypeptide 1 (pituitary) (ADCYAP1), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu16639C NM_001099733 Homo sapiens adenylate cyclase activating polypeptide 1 (pituitary) (ADCYAP1), transcript variant 1, mRNA. Customized vector On-demand 7-9 $209.00
OHu16639C NM_001117 Homo sapiens adenylate cyclase activating polypeptide 1 (pituitary) (ADCYAP1), transcript variant 2, mRNA. Customized vector On-demand 7-9 $209.00
OHu50973C XM_005258081 PREDICTED: Homo sapiens adenylate cyclase activating polypeptide 1 (pituitary) (ADCYAP1), transcript variant X1, mRNA. Customized vector On-demand 7-9 $269.00

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Gene Symbol ADCYAP1
Entrez Gene ID 116
Full Name adenylate cyclase activating polypeptide 1 (pituitary)
Synonyms PACAP
General protein information
Preferred Names
pituitary adenylate cyclase-activating polypeptide
Names
pituitary adenylate cyclase-activating polypeptide
prepro-PACAP
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

18

18p11

Summary This gene encodes a secreted proprotein that is further processed into multiple mature peptides. These peptides stimulate adenylate cyclase and increase cyclic adenosine monophosphate (cAMP) levels, resulting in the transcriptional activation of target genes. The products of this gene are key mediators of neuroendocrine stress responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013].
Disorder

MIM: 102980

mRNA Protein Product Sequence Price Select
NM_001099733, 153266791 NP_001093203, 153266792 pituitary adenylate cyclase-activating polypeptide preproprotein ORF Sequence $250.00
NM_001117, 452085176 NP_001108, 153266795 pituitary adenylate cyclase-activating polypeptide preproprotein ORF Sequence $250.00
XM_005258081, 530424798 XP_005258138, 530424799 pituitary adenylate cyclase-activating polypeptide isoform X1 ORF Sequence $400.00
KEGG
hsa04911Insulin secretion
WikiPathways
WP706SIDS Susceptibility Pathways
Reactome
REACT_19184GPCR downstream signaling
REACT_19327G alpha (s) signalling events
REACT_14797Signaling by GPCR
REACT_18372Class B/2 (Secretin family receptors)
REACT_18377Glucagon-type ligand receptors
REACT_11061Signalling by NGF
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_11064Activation of TRKA receptors
REACT_11046NGF-independant TRKA activation
REACT_21340GPCR ligand binding
REACT_111102Signal Transduction
Homo sapiens (human)ADCYAP1NP_001093203.1
Pan troglodytes (chimpanzee)ADCYAP1NP_001181872.1
Canis lupus familiaris (dog)ADCYAP1XP_849191.2
Bos taurus (cattle)ADCYAP1NP_001040020.1
Mus musculus (house mouse)Adcyap1NP_033755.1
Rattus norvegicus (Norway rat)Adcyap1NP_058685.1
Gallus gallus (chicken)ADCYAP1NP_001001291.2
Xenopus (Silurana) tropicalis (western clawed frog)adcyap1NP_001096425.1
Process
IDNameEvidence
GO:0001541ovarian follicle developmentIEA
GO:0001662behavioral fear responseIEA
GO:0001821histamine secretionIEA
GO:0002865negative regulation of acute inflammatory response to antigenic stimulusIEA
GO:0002878negative regulation of acute inflammatory response to non-antigenic stimulusIEA
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathwayTAS
GO:0007190activation of adenylate cyclase activityTAS
GO:0007204positive regulation of cytosolic calcium ion concentrationIEA
GO:0007218neuropeptide signaling pathwayIDA
GO:0007267cell-cell signalingTAS
GO:0007565female pregnancyTAS
GO:0008277regulation of G-protein coupled receptor protein signaling pathwayIDA
GO:0008284positive regulation of cell proliferationIEA
GO:0010579positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathwayIDA
GO:0010656negative regulation of muscle cell apoptotic processIEA
GO:0010976positive regulation of neuron projection developmentIEA
GO:0019233sensory perception of painIEA
GO:0019933cAMP-mediated signalingIMP
GO:0021983pituitary gland developmentIEA
GO:0031175neuron projection developmentIDA
GO:0032755positive regulation of interleukin-6 productionIEA
GO:0032854positive regulation of Rap GTPase activityIDA
GO:0032880regulation of protein localizationIDA
GO:0034259negative regulation of Rho GTPase activityIEA
GO:0042594response to starvationIEA
GO:0043267negative regulation of potassium ion transportIEA
GO:0045471response to ethanolIEA
GO:0045786negative regulation of cell cycleIEA
GO:0045860positive regulation of protein kinase activityIDA
GO:0045909positive regulation of vasodilationIEA
GO:0045944positive regulation of transcription from RNA polymerase II promoterIDA
GO:0046034ATP metabolic processIEA
GO:0048011neurotrophin TRK receptor signaling pathwayTAS
GO:0051968positive regulation of synaptic transmission, glutamatergicIEA
GO:0060078regulation of postsynaptic membrane potentialIEA
GO:0060124positive regulation of growth hormone secretionIEA
GO:0060253negative regulation of glial cell proliferationIEA
GO:0070374positive regulation of ERK1 and ERK2 cascadeIDA
GO:0070445regulation of oligodendrocyte progenitor proliferationIEA
GO:0071385cellular response to glucocorticoid stimulusIEA
GO:0090274positive regulation of somatostatin secretionIEA
Component
IDNameEvidence
GO:0005576extracellular regionTAS
GO:0005615extracellular spaceIEA
GO:0043195terminal boutonIEA
Function
IDNameEvidence
GO:0005057receptor signaling protein activityIEA
GO:0005102receptor bindingIPI
GO:0005184neuropeptide hormone activityIDA
GO:0016521pituitary adenylate cyclase activating polypeptide activityIDA
GO:0031858pituitary adenylate cyclase-activating polypeptide receptor bindingIEA
GO:0051428peptide hormone receptor bindingIDA
GO:0051428peptide hormone receptor bindingIPI
GeneCards ADCYAP1
PDB 2JOD, 1GEA, 2D2P
UniProt P18509
Vega OTTHUMG00000131479
MIM 102980
Ensembl ENSG00000141433
HGNC 241
HPRD 02369

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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