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APOA5 apolipoprotein A-V [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001166598 Homo sapiens apolipoprotein A-V (APOA5), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $549.00 14
NM_052968 Homo sapiens apolipoprotein A-V (APOA5), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $549.00 14
XM_006718761 PREDICTED: Homo sapiens apolipoprotein A-V (APOA5), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $549.00 14

*Business Day

Related Services

Gene Symbol APOA5
Entrez Gene ID 116519
Full Name apolipoprotein A-V
Synonyms APOAV, RAP3
General protein information
Preferred Names
apolipoprotein A-V
Names
apolipoprotein A-V
apo-AV
apolipoprotein A5
regeneration-associated protein 3
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11q23

Summary The protein encoded by this gene is an apolipoprotein that plays an important role in regulating the plasma triglyceride levels, a major risk factor for coronary artery disease. It is a component of high density lipoprotein and is highly similar to a rat protein that is upregulated in response to liver injury. Mutations in this gene have been associated with hypertriglyceridemia and hyperlipoproteinemia type 5. This gene is located proximal to the apolipoprotein gene cluster on chromosome 11q23. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Oct 2009].
Disorder

MIM: 606368

{Hypertriglyceridemia, susceptibility to}, 145750 (3);

mRNA Protein Product Sequence Price Select
NM_001166598, 262231736 NP_001160070, 262231737 apolipoprotein A-V precursor ORF Sequence $400.00
NM_052968, 262231738 NP_443200, 63079709 apolipoprotein A-V precursor ORF Sequence $400.00
XM_006718761, 578821967 XP_006718824, 578821968 apolipoprotein A-V isoform X1 ORF Sequence $400.00
KEGG
hsa03320PPAR signaling pathway
WikiPathways
WP430Statin Pathway
Reactome
REACT_19241Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
REACT_602Lipid digestion, mobilization, and transport
REACT_6823Lipoprotein metabolism
REACT_6841Chylomicron-mediated lipid transport
REACT_22279Fatty acid, triacylglycerol, and ketone body metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_111217Metabolism
REACT_116145PPARA activates gene expression
Homo sapiens (human)APOA5NP_443200.2
Pan troglodytes (chimpanzee)APOA5XP_003313361.1
Macaca mulatta (Rhesus monkey)APOA5XP_002799851.1
Canis lupus familiaris (dog)APOA5XP_546511.1
Bos taurus (cattle)APOA5NP_001076961.1
Mus musculus (house mouse)Apoa5NP_536682.2
Rattus norvegicus (Norway rat)Apoa5NP_542143.1
Gallus gallus (chicken)APOA5XP_004948132.1
Xenopus (Silurana) tropicalis (western clawed frog)apoa5NP_001116904.1
Process
IDNameEvidence
GO:0006641triglyceride metabolic processIDA
GO:0006641triglyceride metabolic processIMP
GO:0006869lipid transportIDA
GO:0009725response to hormoneIEA
GO:0010898positive regulation of triglyceride catabolic processIDA
GO:0010902positive regulation of very-low-density lipoprotein particle remodelingIDA
GO:0019433triglyceride catabolic processIMP
GO:0031100organ regenerationIEA
GO:0034370triglyceride-rich lipoprotein particle remodelingIEA
GO:0042157lipoprotein metabolic processIEA
GO:0042246tissue regenerationIEP
GO:0042632cholesterol homeostasisIDA
GO:0044255cellular lipid metabolic processTAS
GO:0044281small molecule metabolic processTAS
GO:0045723positive regulation of fatty acid biosynthetic processIDA
GO:0048260positive regulation of receptor-mediated endocytosisTAS
GO:0050996positive regulation of lipid catabolic processIDA
GO:0051006positive regulation of lipoprotein lipase activityIDA
GO:0055090acylglycerol homeostasisIDA
GO:0055090acylglycerol homeostasisIMP
GO:0070328triglyceride homeostasisIDA
GO:0070328triglyceride homeostasisIMP
Component
IDNameEvidence
GO:0005576extracellular regionIDA
GO:0005576extracellular regionTAS
GO:0005615extracellular spaceIDA
GO:0034361very-low-density lipoprotein particleIDA
GO:0034362low-density lipoprotein particleIDA
GO:0034364high-density lipoprotein particleIDA
GO:0042627chylomicronIDA
Function
IDNameEvidence
GO:0005543phospholipid bindingIDA
GO:0008047enzyme activator activityIDA
GO:0008201heparin bindingIDA
GO:0008201heparin bindingIDA
GO:0008289lipid bindingIDA
GO:0019899enzyme bindingIDA
GO:0031210phosphatidylcholine bindingIDA
GO:0035473lipase bindingIPI
GO:0050750low-density lipoprotein particle receptor bindingIPI
GO:0060229lipase activator activityIMP
GO:0060230lipoprotein lipase activator activityIDA
GO:0070325lipoprotein particle receptor bindingIPI
GeneCards APOA5
UniProt Q6Q788
Vega OTTHUMG00000046116
MIM 606368
Ensembl ENSG00000110243
HGNC 17288
HPRD 06966

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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