Sequence in raw or FASTA format:
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10 [
Homo sapiens (human)]
Gene Symbol SLC16A10
Entrez Gene ID
Full Name solute carrier family 16 (aromatic amino acid transporter), member 10
Synonyms MCT10, PRO0813, TAT1
General protein information
monocarboxylate transporter 10
monocarboxylate transporter 10
T-type amino acid transporter 1
aromatic amino acid transporter 1
solute carrier family 16 member 10
solute carrier family 16, member 10 (aromatic amino acid transporter)
solute carrier family 16 (monocarboxylic acid transporters), member 10
Gene Type protein-coding
Homo sapiens (human)
Chromosome:6 Map Location:6q21-q22
Summary SLC16A10 is a member of a family of plasma membrane amino acid transporters that mediate the Na(+)-independent transport of aromatic amino acids across the plasma membrane.[supplied by OMIM, Apr 2004].
hsa04974 Protein digestion and absorption
hsa04919 Thyroid hormone signaling pathway
REACT_19118 SLC-mediated transmembrane transport
REACT_19397 Transport of inorganic cations/anions and amino acids/oligopeptides
REACT_13796 Amino acid transport across the plasma membrane
REACT_15518 Transmembrane transport of small molecules
Related articles in PubMed Genome-wide association study identifies multiple loci influencing human serum metabolite levels. Kettunen J, et al. Nat Genet, 2012 Jan 29. PMID 22286219. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473. Human metabolic individuality in biomedical and pharmaceutical research. Suhre K, et al. Nature, 2011 Aug 31. PMID 21886157. Expression of thyroid hormone transporters in the human hypothalamus. Alkemade A, et al. J Clin Endocrinol Metab, 2011 Jun. PMID 21508134. See all (16) citations in PubMed See citations in PubMed for homologs of this gene provided by HomoloGene
GeneRIFs: Gene References Into Functions
What's a GeneRIF?
Compared with the adult cerebral cortex, mRNAs encoding OATP1A2, OATP1C1, OATP3A1 variant 2, OATP4A1, LAT2 and CD98 were reduced in fetal cortex at different gestational ages, whilst mRNAs encoding MCT8, MCT10, OATP3A1 variant 1 and LAT1 were similar.
Title: The expression of thyroid hormone transporters in the human fetal cerebral cortex during early development and in N-Tera-2 neurodifferentiation.
monocarboxylate transporter 10 facilitates bromoacetyl [(125)I] iodothyronine transport, but is not labeled by it
Title: The thyroid hormone transporters MCT8 and MCT10 transport the affinity-label N-bromoacetyl-[(125)I]T3 but are not modified by it.
The strong expression of MCT10 and OATP1C1 in the human hypothalamus indicates a possible role in the regulation of the hypothalamus-pituitary-thyroid axis.
Title: Expression of thyroid hormone transporters in the human hypothalamus.
Increased MCT8 and decreased MCT10 expression within placentae of pregnancies complicated by IUGR may contribute to aberrant development of the fetoplacental unit.
Title: Expression of thyroid hormone transporters in the human placenta and changes associated with intrauterine growth restriction.
MCT10 is at least as active a thyroid hormone transporter as hMCT8, and that both transporters facilitate iodothyronine uptake as well as efflux.
Title: Effective cellular uptake and efflux of thyroid hormone by human monocarboxylate transporter 10.
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