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Sequence in raw or FASTA format:


Blast Method:


TPP1 tripeptidyl peptidase I [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000391 Homo sapiens tripeptidyl peptidase I (TPP1), mRNA. GenEZ ORF Cloning On-demand $699.00 18

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Gene Symbol TPP1
Entrez Gene ID 1200
Full Name tripeptidyl peptidase I
Synonyms CLN2, LPIC, MGC21297
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome. [provided by RefSeq, Jul 2008].

MIM: 607998

Ceroid-lipofuscinosis, neuronal 2, classic late infantile, 204500

mRNA Protein Product Sequence Price Select
NM_000391, 118582287 NP_000382, 5729770 tripeptidyl-peptidase 1 preproprotein ORF Sequence $550.00
REACT_18356Unfolded Protein Response
REACT_18368Activation of Chaperones by IRE1alpha
REACT_18273Activation of Chaperone Genes by XBP1(S)
REACT_15380Diabetes pathways
Homo sapiens (human)TPP1NP_000382.3
Pan troglodytes (chimpanzee)TPP1NP_001013025.1
Macaca mulatta (Rhesus monkey)LOC709838XP_001108748.1
Canis lupus familiaris (dog)TPP1NP_001013869.1
Bos taurus (cattle)TPP1NP_001069186.1
Mus musculus (house mouse)Tpp1NP_034036.1
Rattus norvegicus (Norway rat)Tpp1NP_112647.1
Gallus gallus (chicken)TPP1XP_423326.3
Danio rerio (zebrafish)tpp1NP_001122270.1
GeneCards TPP1
PDB 1R60, 3EDY, 3EE6
UniProt O14773
MIM 607998
Ensembl ENSG00000166340
HGNC 2073
HPRD 06415

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
tripeptidyl-peptidase 1
tripeptidyl-peptidase 1
tripeptidyl aminopeptidase
growth-inhibiting protein 1
cell growth-inhibiting gene 1 protein
lysosomal pepstatin insensitive protease


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