LRRK2 leucine-rich repeat kinase 2 [Homo sapiens (human)]

Gene Symbol	LRRK2
Entrez Gene ID	120892
Full Name	leucine-rich repeat kinase 2
Synonyms	AURA17, DARDARIN, PARK8, RIPK7, ROCO2
Gene Type	protein-coding
Organism	Homo sapiens (human)
Genome	Chromosome:12 Map Location:12q12
Summary	This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq].
Disorder	MIM: 609007 Parkinson disease-8, 607060 (3)

mRNA	NM_198578, 171846277
Protein	NP_940980, 171846278
Product	leucine-rich repeat serine/threonine-protein kinase 2
RefSeq Status	REVIEWED

KEGG

hsa05012

Parkinson's disease

Homo sapiens (human)	LRRK2	NP_940980.3
Pan troglodytes (chimpanzee)	LRRK2	XP_001168494.1
Canis lupus familiaris (dog)	LRRK2	XP_543734.2
Bos taurus (cattle)	LRRK2	XP_615760.3
Mus musculus (house mouse)	Lrrk2	NP_080006.2
Rattus norvegicus (Norway rat)	Lrrk2	XP_235581.4
Danio rerio (zebrafish)	lrrk2	XP_002667002.1

Process

ID	Name	Evidence
GO:0000165	MAPKKK cascade	IDA
GO:0000186	activation of MAPKK activity	IDA
GO:0001934	positive regulation of protein phosphorylation	IMP
GO:0006979	response to oxidative stress	IMP
GO:0007264	small GTPase mediated signal transduction	IEA
GO:0007406	negative regulation of neuroblast proliferation	IMP
GO:0007528	neuromuscular junction development	IMP
GO:0008340	determination of adult lifespan	IMP
GO:0010508	positive regulation of autophagy	ISS
GO:0010942	positive regulation of cell death	IMP
GO:0014043	negative regulation of neuron maturation	IMP
GO:0018105	peptidyl-serine phosphorylation	IDA
GO:0021772	olfactory bulb development	IMP
GO:0022028	tangential migration from the subventricular zone to the olfactory bulb	IMP
GO:0031398	positive regulation of protein ubiquitination	IDA
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISS
GO:0035564	regulation of kidney size	ISS
GO:0035640	exploration behavior	IMP
GO:0040012	regulation of locomotion	IMP
GO:0042391	regulation of membrane potential	IMP
GO:0043068	positive regulation of programmed cell death	IDA
GO:0043547	positive regulation of GTPase activity	IDA
GO:0046777	protein autophosphorylation	IDA
GO:0046777	protein autophosphorylation	IMP
GO:0048312	intracellular distribution of mitochondria	IMP
GO:0060161	positive regulation of dopamine receptor signaling pathway	IMP
GO:0061002	negative regulation of dendritic spine morphogenesis	IMP
GO:0070997	neuron death	IMP
GO:2000173	negative regulation of branching morphogenesis of a nerve	IMP

Component

ID	Name	Evidence
GO:0005622	intracellular	IEA
GO:0005624	membrane fraction	IDA
GO:0005737	cytoplasm	IDA
GO:0005792	microsome	IEA
GO:0016020	membrane	IEA
GO:0019717	synaptosome	IEA
GO:0030424	axon	IEA
GO:0030425	dendrite	IEA
GO:0032473	external side of mitochondrial outer membrane	IDA

Function

ID	Name	Evidence
GO:0000166	nucleotide binding	IEA
GO:0003924	GTPase activity	IDA
GO:0004672	protein kinase activity	IDA
GO:0004674	protein serine/threonine kinase activity	IDA
GO:0004708	MAP kinase kinase activity	IDA
GO:0005096	GTPase activator activity	IDA
GO:0005515	protein binding	IPI
GO:0005524	ATP binding	IEA
GO:0005525	GTP binding	IDA
GO:0015631	tubulin binding	IDA
GO:0034211	GTP-dependent protein kinase activity	IDA
GO:0034211	GTP-dependent protein kinase activity	IMP
GO:0042803	protein homodimerization activity	IPI

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RefSeq Accession	Definition	Sequence	Price	Select
NM_198578	Homo sapiens leucine-rich repeat kinase 2 (LRRK2), mRNA.	Full Length	Quote
NM_198578	Homo sapiens leucine-rich repeat kinase 2 (LRRK2), mRNA.	ORF Sequence	$3412.80