• THAT   AND
  • THAT   AND


Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


LRRK2 leucine-rich repeat kinase 2 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu19500 NM_198578 Homo sapiens leucine-rich repeat kinase 2 (LRRK2), mRNA. pcDNA3.1+-DYK On-demand 35 $3749.00
OHu46306 XM_005268629 PREDICTED: Homo sapiens leucine-rich repeat kinase 2 (LRRK2), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 35 $3749.00
OHu19500C NM_198578 Homo sapiens leucine-rich repeat kinase 2 (LRRK2), mRNA. Customized vector On-demand 35 $3749.00
OHu46306C XM_005268629 PREDICTED: Homo sapiens leucine-rich repeat kinase 2 (LRRK2), transcript variant X1, mRNA. Customized vector On-demand 35 $3749.00

*Business Day

Related Services

Gene Symbol LRRK2
Entrez Gene ID 120892
Full Name leucine-rich repeat kinase 2
Synonyms AURA17, DARDARIN, PARK8, RIPK7, ROCO2
General protein information
Preferred Names
leucine-rich repeat serine/threonine-protein kinase 2
Names
leucine-rich repeat serine/threonine-protein kinase 2
augmented in rheumatoid arthritis 17
NP_940980.3
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

12

12q12

Summary This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008].
Disorder

MIM: 609007

Parkinson disease-8, 607060 (3)

mRNA Protein Product Sequence Price Select
NM_198578, 171846277 NP_940980, 171846278 leucine-rich repeat serine/threonine-protein kinase 2 ORF Sequence $3500.00
XM_005268629, 530399724 XP_005268686, 530399725 leucine-rich repeat serine/threonine-protein kinase 2 isoform X1 ORF Sequence $3500.00
KEGG
hsa05012Parkinson's disease
WikiPathways
WP382MAPK signaling pathway
WP399Wnt Signaling Pathway and Pluripotency
WP2371Parkinsons Disease Pathway
Homo sapiens (human)LRRK2NP_940980.3
Pan troglodytes (chimpanzee)LRRK2XP_001168494.1
Macaca mulatta (Rhesus monkey)LRRK2XP_002798616.1
Canis lupus familiaris (dog)LRRK2XP_543734.3
Bos taurus (cattle)LRRK2NP_001193015.1
Mus musculus (house mouse)Lrrk2NP_080006.3
Rattus norvegicus (Norway rat)Lrrk2NP_001178718.1
Gallus gallus (chicken)LRRK2XP_003640388.2
Danio rerio (zebrafish)lrrk2NP_001188385.1
Xenopus (Silurana) tropicalis (western clawed frog)lrrk2XP_002932250.2
Process
IDNameEvidence
GO:0000165MAPK cascadeIDA
GO:0000186activation of MAPKK activityIDA
GO:0000187activation of MAPK activityIDA
GO:0001934positive regulation of protein phosphorylationIMP
GO:0006184GTP catabolic processIDA
GO:0006914autophagyIEA
GO:0006979response to oxidative stressIMP
GO:0007264small GTPase mediated signal transductionIEA
GO:0007528neuromuscular junction developmentIMP
GO:0008340determination of adult lifespanIMP
GO:0010508positive regulation of autophagyIMP
GO:0010508positive regulation of autophagyISS
GO:0014041regulation of neuron maturationIMP
GO:0018105peptidyl-serine phosphorylationIDA
GO:0018107peptidyl-threonine phosphorylationIDA
GO:0018107peptidyl-threonine phosphorylationIMP
GO:0021772olfactory bulb developmentIMP
GO:0022028tangential migration from the subventricular zone to the olfactory bulbIMP
GO:0031398positive regulation of protein ubiquitinationIDA
GO:0032091negative regulation of protein bindingIMP
GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic processISS
GO:0034260negative regulation of GTPase activityIDA
GO:0035564regulation of kidney sizeISS
GO:0035640exploration behaviorIMP
GO:0040012regulation of locomotionIMP
GO:0042391regulation of membrane potentialIMP
GO:0043068positive regulation of programmed cell deathIDA
GO:0043547positive regulation of GTPase activityIDA
GO:0043547positive regulation of GTPase activityIEA
GO:0046777protein autophosphorylationIDA
GO:0046777protein autophosphorylationIMP
GO:0048312intracellular distribution of mitochondriaIMP
GO:0048812neuron projection morphogenesisIMP
GO:0051900regulation of mitochondrial depolarizationIMP
GO:0060161positive regulation of dopamine receptor signaling pathwayIMP
GO:0061001regulation of dendritic spine morphogenesisIMP
GO:0070997neuron deathIMP
GO:0071407cellular response to organic cyclic compoundIEA
GO:1901214regulation of neuron deathIMP
GO:1902692regulation of neuroblast proliferationIMP
GO:1902803regulation of synaptic vesicle transportISS
GO:1902823negative regulation of late endosome to lysosome transportTAS
GO:1903125negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylationIDA
GO:2000172regulation of branching morphogenesis of a nerveIMP
GO:2000300regulation of synaptic vesicle exocytosisIMP
Component
IDNameEvidence
GO:0005615extracellular spaceIDA
GO:0005737cytoplasmIDA
GO:0005739mitochondrionIDA
GO:0005741mitochondrial outer membraneISS
GO:0005743mitochondrial inner membraneISS
GO:0005759mitochondrial matrixISS
GO:0005764lysosomeISS
GO:0005768endosomeISS
GO:0005783endoplasmic reticulumISS
GO:0005794Golgi apparatusISS
GO:0005802trans-Golgi networkIEA
GO:0005829cytosolIDA
GO:0005886plasma membraneIEA
GO:0008021synaptic vesicleIEA
GO:0016234inclusion bodyIMP
GO:0030424axonIDA
GO:0030424axonISS
GO:0030425dendriteIDA
GO:0030425dendriteISS
GO:0031410cytoplasmic vesicleISS
GO:0031966mitochondrial membraneIDA
GO:0032473cytoplasmic side of mitochondrial outer membraneIDA
GO:0032839dendrite cytoplasmIDA
GO:0043005neuron projectionIDA
GO:0043025neuronal cell bodyIDA
GO:0043204perikaryonIDA
GO:0043204perikaryonISS
GO:0045121membrane raftIEA
GO:0070062extracellular vesicular exosomeIDA
Function
IDNameEvidence
GO:0000149SNARE bindingIPI
GO:0001948glycoprotein bindingIPI
GO:0003779actin bindingIPI
GO:0003924GTPase activityIDA
GO:0004672protein kinase activityIDA
GO:0004674protein serine/threonine kinase activityIDA
GO:0004708MAP kinase kinase activityIDA
GO:0004857enzyme inhibitor activityIDA
GO:0005096GTPase activator activityIDA
GO:0005515protein bindingIPI
GO:0005524ATP bindingIEA
GO:0005525GTP bindingIDA
GO:0015631tubulin bindingIDA
GO:0016301kinase activityIDA
GO:0017048Rho GTPase bindingIPI
GO:0017075syntaxin-1 bindingIPI
GO:0030276clathrin bindingIPI
GO:0034211GTP-dependent protein kinase activityIDA
GO:0034211GTP-dependent protein kinase activityIMP
GO:0042802identical protein bindingIPI
GO:0042803protein homodimerization activityIPI
GO:0044325ion channel bindingIPI
GO:0051018protein kinase A bindingIPI
GeneCards LRRK2
PDB 3D6T, 2ZEJ
UniProt Q5S007, Q17RV3
Vega OTTHUMG00000059742
MIM 609007
Ensembl ENSG00000188906
HGNC 18618

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.