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Sequence in raw or FASTA format:

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LRRK2 leucine-rich repeat kinase 2 [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_198578 Homo sapiens leucine-rich repeat kinase 2 (LRRK2), mRNA. ORF Sequence $3412.80
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Gene Symbol LRRK2
Entrez Gene ID 120892
Full Name leucine-rich repeat kinase 2
Synonyms AURA17, DARDARIN, PARK8, RIPK7, ROCO2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

12

12q12

Summary This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008].
Disorder

MIM: 609007

Parkinson disease-8, 607060 (3)

mRNA Protein Product Sequence Price Select
NM_198578, 171846277 NP_940980, 171846278 leucine-rich repeat serine/threonine-protein kinase 2 Full Length $0.00
ORF Sequence $3412.80
KEGG
hsa05012Parkinson's disease
WikiPathways
WP382MAPK signaling pathway
WP399Wnt Signaling Pathway and Pluripotency
WP2371Parkinsons Disease Pathway
Homo sapiens (human)LRRK2NP_940980.3
Pan troglodytes (chimpanzee)LRRK2XP_001168494.1
Macaca mulatta (Rhesus monkey)LRRK2XP_002798616.1
Canis lupus familiaris (dog)LRRK2XP_543734.3
Bos taurus (cattle)LRRK2NP_001193015.1
Mus musculus (house mouse)Lrrk2NP_080006.3
Rattus norvegicus (Norway rat)Lrrk2XP_235581.5
Gallus gallus (chicken)LOC427844XP_003640388.1
Danio rerio (zebrafish)lrrk2NP_001188385.1
GeneCards LRRK2
PDB 3D6T, 2ZEJ
UniProt Q5S007, Q17RV3
MIM 609007
Ensembl ENSG00000188906
HGNC 18618

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
leucine-rich repeat serine/threonine-protein kinase 2
Names
leucine-rich repeat serine/threonine-protein kinase 2
augmented in rheumatoid arthritis 17
NP_940980.3

Interactant

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