PLIN2 perilipin 2 [Homo sapiens (human)]
| Gene Symbol | PLIN2 |
| Entrez Gene ID | 123 |
| Full Name | perilipin 2 |
| Synonyms | ADFP, ADRP, MGC10598 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
9 9p22.1 |
| Summary | The protein encoded by this gene belongs to the perilipin family, members of which coat intracellular lipid storage droplets. This protein is associated with the lipid globule surface membrane material, and maybe involved in development and maintenance of adipose tissue. However, it is not restricted to adipocytes as previously thought, but is found in a wide range of cultured cell lines, including fibroblasts, endothelial and epithelial cells, and tissues, such as lactating mammary gland, adrenal cortex, Sertoli and Leydig cells, and hepatocytes in alcoholic liver cirrhosis, suggesting that it may serve as a marker of lipid accumulation in diverse cell types and diseases. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq]. |
| Disorder | MIM: 103195 |
| hif1_tfpathway | HIF-1-alpha transcription factor network |
WikiPathways
| WP236 | Adipogenesis |
Reactome
| REACT_22279 | Fatty acid, triacylglycerol, and ketone body metabolism |
| REACT_22258 | Metabolism of lipids and lipoproteins |
| REACT_19241 | Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) |
| Homo sapiens (human) | PLIN2 | NP_001113.2 |
| Pan troglodytes (chimpanzee) | PLIN2 | XP_520505.2 |
| Canis lupus familiaris (dog) | PLIN2 | XP_531946.1 |
| Bos taurus (cattle) | PLIN2 | NP_776405.1 |
| Mus musculus (house mouse) | Plin2 | NP_031434.3 |
| Rattus norvegicus (Norway rat) | Adfp | NP_001007145.1 |
| Gallus gallus (chicken) | ADFP | NP_001026591.1 |
| Danio rerio (zebrafish) | plin2 | NP_001025433.1 |
| ID | Name | Evidence |
| GO:0014070 | response to organic cyclic compound | IEA |
| GO:0015909 | long-chain fatty acid transport | IEA |
| GO:0019915 | lipid storage | IEA |
| GO:0042493 | response to drug | IEA |
| GO:0044255 | cellular lipid metabolic process | TAS |
Component
| ID | Name | Evidence |
| GO:0005576 | extracellular region | TAS |
| GO:0005634 | nucleus | IEA |
| GO:0005737 | cytoplasm | IEA |
| GO:0005783 | endoplasmic reticulum | TAS |
| GO:0005811 | lipid particle | IEA |
| GO:0005886 | plasma membrane | IEA |
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