• THAT   AND
  • THAT   AND


Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


CCR5 chemokine (C-C motif) receptor 5 [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_000579 Homo sapiens chemokine (C-C motif) receptor 5 (gene/pseudogene) (CCR5), transcript variant A, mRNA. ORF Sequence $307.11
Peptide Services
Antibody Services
Protein Services
NM_001100168 Homo sapiens chemokine (C-C motif) receptor 5 (gene/pseudogene) (CCR5), transcript variant B, mRNA. ORF Sequence $307.11
Peptide Services
Antibody Services
Protein Services


Gene Symbol CCR5
Entrez Gene ID 1234
Full Name chemokine (C-C motif) receptor 5
Synonyms CC-CKR-5, CCCKR5, CD195, CKR-5, CKR5, CMKBR5, FLJ78003, IDDM22
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

3

3p21.31

Summary This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
Disorder

MIM: 601373

{HIV infection, susceptibility/resistance to} (3); {West nile virus,

mRNA Protein Product Sequence Price Select
NM_000579, 154091329 NP_000570, 4502639 C-C chemokine receptor type 5 Full Length $1290.10
ORF Sequence $307.11
NM_001100168, 154091327 NP_001093638, 154091328 C-C chemokine receptor type 5 Full Length $1207.85
ORF Sequence $307.11
KEGG
hsa04144Endocytosis
hsa04060Cytokine-cytokine receptor interaction
hsa05203Viral carcinogenesis
hsa05145Toxoplasmosis
hsa04062Chemokine signaling pathway
Pathway Interaction Database
il12_2pathwayIL12-mediated signaling events
WikiPathways
WP117GPCRs, Other
WP24Peptide GPCRs
WP455GPCRs, Class A Rhodopsin-like
WP69TCR Signaling Pathway
Reactome
REACT_14797Signaling by GPCR
REACT_19231G alpha (i) signalling events
REACT_6903Binding and entry of HIV virion
REACT_111102Signal Transduction
REACT_19184GPCR downstream signaling
REACT_14828Class A/1 (Rhodopsin-like receptors)
REACT_21340GPCR ligand binding
REACT_6256HIV Life Cycle
REACT_15344Chemokine receptors bind chemokines
REACT_116125Disease
REACT_14819Peptide ligand-binding receptors
REACT_6185HIV Infection
REACT_6266Early Phase of HIV Life Cycle
Homo sapiens (human)CCR5NP_000570.1
Pan troglodytes (chimpanzee)CCR5NP_001009046.1
Macaca mulatta (Rhesus monkey)CCR5NP_001036238.2
Canis lupus familiaris (dog)CCR5NP_001012342.2
Bos taurus (cattle)CCR5NP_001011672.2
Mus musculus (house mouse)Ccr5NP_034047.2
Rattus norvegicus (Norway rat)Ccr5NP_446412.2
Gallus gallus (chicken)CCR5NP_001039299.1
Danio rerio (zebrafish)LOC100005081XP_001344220.3
Danio rerio (zebrafish)LOC100004625XP_001343879.1
Danio rerio (zebrafish)LOC100004988XP_001344151.1
GeneCards CCR5
PDB 1OPN, 1NE0, 1OPW, 1OPT, 1ND8, 2RRS, 2L87, 2RLL
UniProt Q38L21, P51681
MIM 601373
Ensembl ENSG00000160791
HGNC 1606
HPRD 03223

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
C-C chemokine receptor type 5
Names
C-C chemokine receptor type 5
chemr13
HIV-1 fusion coreceptor
chemokine receptor CCR5
C-C motif chemokine receptor 5 A159A

Interactant

Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.

Secured Online Quotation
Email: gene@genscript.com
Phone: 1-877-436-7274 (Toll-Free) 1-732-885-9188
Fax: 1-732-210-0262 1-732-885-5878