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CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000579 Homo sapiens chemokine (C-C motif) receptor 5 (gene/pseudogene) (CCR5), transcript variant A, mRNA. GenEZ ORF Cloning In-stock $418.00 $369.00 10
NM_001100168 Homo sapiens chemokine (C-C motif) receptor 5 (gene/pseudogene) (CCR5), transcript variant B, mRNA. GenEZ ORF Cloning In-stock $418.00 $369.00 10

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Related Services

Gene Symbol CCR5
Entrez Gene ID 1234
Full Name chemokine (C-C motif) receptor 5 (gene/pseudogene)
Synonyms CC-CKR-5, CCCKR5, CCR-5, CD195, CKR-5, CKR5, CMKBR5, IDDM22
General protein information
Preferred Names
C-C chemokine receptor type 5
Names
C-C chemokine receptor type 5
chemr13
HIV-1 fusion coreceptor
chemokine receptor CCR5
C-C motif chemokine receptor 5 A159A
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

3

3p21.31

Summary This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
Disorder

MIM: 601373

{HIV infection, susceptibility/resistance to} (3); {West nile virus,

mRNA Protein Product Sequence Price Select
NM_000579, 154091329 NP_000570, 4502639 C-C chemokine receptor type 5 ORF Sequence $269.00
NM_001100168, 154091327 NP_001093638, 154091328 C-C chemokine receptor type 5 ORF Sequence $269.00
KEGG
hsa04060Cytokine-cytokine receptor interaction
hsa04062Chemokine signaling pathway
hsa04144Endocytosis
hsa05145Toxoplasmosis
hsa05203Viral carcinogenesis
WikiPathways
WP117GPCRs, Other
WP455GPCRs, Class A Rhodopsin-like
WP69TCR Signaling Pathway
WP24Peptide GPCRs
Pathway Interaction Database
il12_2pathwayIL12-mediated signaling events
Reactome
REACT_19184GPCR downstream signaling
REACT_19231G alpha (i) signalling events
REACT_6185HIV Infection
REACT_6266Early Phase of HIV Life Cycle
REACT_6256HIV Life Cycle
REACT_6903Binding and entry of HIV virion
REACT_14828Class A/1 (Rhodopsin-like receptors)
REACT_15344Chemokine receptors bind chemokines
REACT_14797Signaling by GPCR
REACT_14819Peptide ligand-binding receptors
REACT_21340GPCR ligand binding
REACT_111102Signal Transduction
REACT_116125Disease
Homo sapiens (human)CCR5NP_001093638.1
Pan troglodytes (chimpanzee)CCR5NP_001009046.1
Macaca mulatta (Rhesus monkey)CCR5NP_001036238.2
Canis lupus familiaris (dog)CCR5NP_001012342.2
Bos taurus (cattle)CCR5NP_001011672.2
Mus musculus (house mouse)Ccr5NP_034047.2
Rattus norvegicus (Norway rat)Ccr5NP_446412.2
Danio rerio (zebrafish)LOC100005081XP_001344220.4
Danio rerio (zebrafish)LOC100004625XP_001343879.1
Danio rerio (zebrafish)LOC100004988XP_001344151.1
Xenopus (Silurana) tropicalis (western clawed frog)LOC101731980XP_004915406.1
Process
IDNameEvidence
GO:0000165MAPK cascadeIEP
GO:0002407dendritic cell chemotaxisTAS
GO:0006816calcium ion transportIDA
GO:0006935chemotaxisTAS
GO:0006954inflammatory responseIEA
GO:0006955immune responseIEA
GO:0006968cellular defense responseTAS
GO:0007166cell surface receptor signaling pathwayTAS
GO:0007186G-protein coupled receptor signaling pathwayIMP
GO:0007204positive regulation of cytosolic calcium ion concentrationTAS
GO:0007267cell-cell signalingIDA
GO:0014808release of sequestered calcium ion into cytosol by sarcoplasmic reticulumIDA
GO:0016032viral processTAS
GO:0019722calcium-mediated signalingIDA
GO:0023052signalingIEP
GO:0030260entry into host cellTAS
GO:0070098chemokine-mediated signaling pathwayIDA
GO:0070098chemokine-mediated signaling pathwayIEA
GO:0070098chemokine-mediated signaling pathwayNAS
GO:0070098chemokine-mediated signaling pathwayTAS
GO:0070723response to cholesterolIMP
GO:0071222cellular response to lipopolysaccharideIEP
Component
IDNameEvidence
GO:0005737cytoplasmTAS
GO:0005768endosomeIDA
GO:0005886plasma membraneTAS
GO:0005887integral component of plasma membraneTAS
GO:0009897external side of plasma membraneIDA
GO:0009986cell surfaceIDA
Function
IDNameEvidence
GO:0003779actin bindingIDA
GO:0004435phosphatidylinositol phospholipase C activityTAS
GO:0004950chemokine receptor activityTAS
GO:0005515protein bindingIPI
GO:0015026coreceptor activityTAS
GO:0016493C-C chemokine receptor activityIDA
GO:0016493C-C chemokine receptor activityNAS
GO:0019957C-C chemokine bindingIPI
GO:0071791chemokine (C-C motif) ligand 5 bindingIPI
GeneCards CCR5
PDB 1OPN, 4MBS, 1NE0, 1OPW, 1OPT, 1ND8, 2RRS, 2L87, 2RLL
UniProt Q38L21, P51681
Vega OTTHUMG00000133481
MIM 601373
Ensembl ENSG00000160791
HGNC 1606
HPRD 03223

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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