• THAT   AND
  • THAT   AND


Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen) [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000091 Homo sapiens collagen, type IV, alpha 3 (Goodpasture antigen) (COL4A3), mRNA. GenEZ ORF Cloning On-demand TBD TBD
XM_005246275 PREDICTED: Homo sapiens collagen, type IV, alpha 3 (Goodpasture antigen) (COL4A3), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand TBD TBD
XM_005246276 PREDICTED: Homo sapiens collagen, type IV, alpha 3 (Goodpasture antigen) (COL4A3), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand TBD TBD
XM_005246277 PREDICTED: Homo sapiens collagen, type IV, alpha 3 (Goodpasture antigen) (COL4A3), transcript variant X3, mRNA. GenEZ ORF Cloning On-demand TBD TBD
XM_005246279 PREDICTED: Homo sapiens collagen, type IV, alpha 3 (Goodpasture antigen) (COL4A3), transcript variant X5, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
XM_005246280 PREDICTED: Homo sapiens collagen, type IV, alpha 3 (Goodpasture antigen) (COL4A3), transcript variant X6, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
XM_006712244 PREDICTED: Homo sapiens collagen, type IV, alpha 3 (Goodpasture antigen) (COL4A3), transcript variant X8, mRNA. GenEZ ORF Cloning On-demand TBD TBD
XM_006712245 PREDICTED: Homo sapiens collagen, type IV, alpha 3 (Goodpasture antigen) (COL4A3), transcript variant X9, mRNA. GenEZ ORF Cloning On-demand TBD TBD

*Business Day

Related Services

Gene Symbol COL4A3
Entrez Gene ID 1285
Full Name collagen, type IV, alpha 3 (Goodpasture antigen)
Synonyms
General protein information
Preferred Names
collagen alpha-3(IV) chain
Names
collagen alpha-3(IV) chain
tumstatin
collagen IV, alpha-3 polypeptide
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

2

2q36-q37

Summary Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. This gene encodes alpha 3. In the Goodpasture syndrome, autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein. A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis. This gene is also linked to an autosomal recessive form of Alport syndrome. The mutations contributing to this syndrome are also located within the exons that encode this C-terminal region. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. [provided by RefSeq, Jun 2010].
Disorder

MIM: 120070

Alport syndrome, autosomal recessive, 203780 (3); Hematuria,

mRNA Protein Product Sequence Price Select
NM_000091, 297632355 NP_000082, 89142730 collagen alpha-3(IV) chain precursor ORF Sequence $2500.00
XM_005246275, 530369760 XP_005246332, 530369761 collagen alpha-3(IV) chain isoform X1 ORF Sequence $2500.00
XM_005246276, 530369762 XP_005246333, 530369763 collagen alpha-3(IV) chain isoform X2 ORF Sequence $2500.00
XM_005246277, 530369764 XP_005246334, 530369765 collagen alpha-3(IV) chain isoform X3 ORF Sequence $2500.00
XM_005246279, 530369769 XP_005246336, 530369770 collagen alpha-3(IV) chain isoform X5 ORF Sequence $1500.00
XM_005246280, 530369771 XP_005246337, 530369772 collagen alpha-3(IV) chain isoform X6 ORF Sequence $1500.00
XM_006712244, 578803608 XP_006712307, 578803609 collagen alpha-3(IV) chain isoform X8 ORF Sequence $1500.00
XM_006712245, 578803610 XP_006712308, 578803611 collagen alpha-3(IV) chain isoform X9 ORF Sequence $1500.00
KEGG
hsa04510Focal adhesion
hsa04512ECM-receptor interaction
hsa05222Small cell lung cancer
hsa05200Pathways in cancer
hsa05146Amoebiasis
hsa04974Protein digestion and absorption
hsa04151PI3K-Akt signaling pathway
Pathway Interaction Database
avb3_integrin_pathwayIntegrins in angiogenesis
Reactome
REACT_18266Axon guidance
REACT_18334NCAM signaling for neurite out-growth
REACT_18312NCAM1 interactions
REACT_13552Integrin cell surface interactions
REACT_16888Signaling by PDGF
REACT_111102Signal Transduction
REACT_111045Developmental Biology
REACT_118779Extracellular matrix organization
REACT_120729Collagen formation
REACT_121139Collagen biosynthesis and modifying enzymes
REACT_150180Assembly of collagen fibrils and other multimeric structures
Homo sapiens (human)COL4A3NP_000082.2
Pan troglodytes (chimpanzee)COL4A3XP_516130.2
Macaca mulatta (Rhesus monkey)COL4A3XP_001101448.2
Canis lupus familiaris (dog)COL4A3XP_005635825.1
Bos taurus (cattle)COL4A3NP_001160001.1
Mus musculus (house mouse)Col4a3NP_031760.2
Rattus norvegicus (Norway rat)Col4a3NP_001129231.1
Gallus gallus (chicken)COL4A3XP_001234730.3
Process
IDNameEvidence
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic processIDA
GO:0007155cell adhesionIEA
GO:0007166cell surface receptor signaling pathwayNAS
GO:0007411axon guidanceTAS
GO:0007605sensory perception of soundTAS
GO:0008015blood circulationTAS
GO:0008283cell proliferationIDA
GO:0008285negative regulation of cell proliferationTAS
GO:0009749response to glucoseIEA
GO:0010951negative regulation of endopeptidase activityNAS
GO:0016525negative regulation of angiogenesisIDA
GO:0022617extracellular matrix disassemblyTAS
GO:0030198extracellular matrix organizationTAS
GO:0030574collagen catabolic processTAS
GO:0032836glomerular basement membrane developmentISS
GO:0072577endothelial cell apoptotic processIDA
Component
IDNameEvidence
GO:0005576extracellular regionTAS
GO:0005587collagen type IV trimerIDA
GO:0005604basement membraneIDA
GO:0005788endoplasmic reticulum lumenTAS
Function
IDNameEvidence
GO:0005178integrin bindingIDA
GO:0005178integrin bindingTAS
GO:0005198structural molecule activityNAS
GO:0005201extracellular matrix structural constituentIEA
GO:0005515protein bindingIPI
GO:0008191metalloendopeptidase inhibitor activityNAS
GeneCards COL4A3
UniProt Q01955
Vega OTTHUMG00000149891
MIM 120070
Ensembl ENSG00000169031
HGNC 2204
HPRD 00354

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the COL4A3 gene?

The COL4A3 gene provides instructions for making one component of type IV collagen, which is a flexible protein. Specifically, this gene makes the alpha3(IV) chain of type IV collagen. This chain combines with two other types of alpha (IV) chains (the alpha4 and alpha5 chains) to make a complete type IV collagen molecule. Type IV collagen molecules attach to each other to form complex protein networks. These networks make up a large portion of basement membranes, which are thin sheet-like structures that separate and support cells in many tissues. Type IV collagen alpha3-4-5 networks play an especially important role in the basement membranes of the kidney, inner ear, and eye.

Interactant

Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.