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PROKR2 prokineticin receptor 2 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_144773 Homo sapiens prokineticin receptor 2 (PROKR2), mRNA. GenEZ ORF Cloning In-stock $418.00 $369.00 10
XM_005260663 PREDICTED: Homo sapiens prokineticin receptor 2 (PROKR2), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $549.00 14

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Gene Symbol PROKR2
Entrez Gene ID 128674
Full Name prokineticin receptor 2
Synonyms GPR73L1, GPR73b, GPRg2, HH3, KAL3, PKR2, dJ680N4.3
General protein information
Preferred Names
prokineticin receptor 2
Names
prokineticin receptor 2
PK-R2
G protein-coupled receptor 73-like 1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

20

20p12.3

Summary Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor for prokineticins. The encoded protein is similar in sequence to GPR73, another G protein-coupled receptor for prokineticins. [provided by RefSeq, Jul 2008].
Disorder

MIM: 607123

Kallmann syndrome 3, 244200 (3)

mRNA Protein Product Sequence Price Select
NM_144773, 30581162 NP_658986, 21426829 prokineticin receptor 2 ORF Sequence $269.00
XM_005260663, 530425613 XP_005260720, 530425614 prokineticin receptor 2 isoform X1 ORF Sequence $400.00
WikiPathways
WP117GPCRs, Other
Reactome
REACT_19184GPCR downstream signaling
REACT_18283G alpha (q) signalling events
REACT_14797Signaling by GPCR
REACT_14819Peptide ligand-binding receptors
REACT_14828Class A/1 (Rhodopsin-like receptors)
REACT_21340GPCR ligand binding
REACT_111102Signal Transduction
REACT_120966Gastrin-CREB signalling pathway via PKC and MAPK
Homo sapiens (human)PROKR2NP_658986.1
Pan troglodytes (chimpanzee)PROKR2XP_001166012.1
Canis lupus familiaris (dog)PROKR2XP_851026.1
Bos taurus (cattle)PROKR2NP_777065.1
Mus musculus (house mouse)Prokr2NP_659193.3
Rattus norvegicus (Norway rat)Prokr2NP_620434.1
Gallus gallus (chicken)PROKR2NP_001138701.1
Danio rerio (zebrafish)LOC798231NP_001166878.1
Xenopus (Silurana) tropicalis (western clawed frog)prokr2XP_002931802.1
Process
IDNameEvidence
GO:0007218neuropeptide signaling pathwayIEA
GO:0007623circadian rhythmIEA
Component
IDNameEvidence
GO:0005886plasma membraneTAS
GO:0016021integral component of membraneIEA
Function
IDNameEvidence
GO:0004983neuropeptide Y receptor activityIEA
GeneCards PROKR2
UniProt Q8NFJ6
Vega OTTHUMG00000031800
MIM 607123
Ensembl ENSG00000101292
HGNC 15836
HPRD 08453

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the PROKR2 gene?

The PROKR2 gene provides instructions for making a protein called prokineticin receptor 2. This receptor interacts with a protein called prokineticin 2 (produced from the PROK2 gene). On the cell surface, prokineticin 2 attaches to the receptor like a key in a lock. When the two proteins are connected, they trigger a series of chemical signals within the cell that regulate various cell functions.

In animal studies, prokineticin 2 and its receptor have been shown to play a role in the normal development of the olfactory bulb, which is a group of nerve cells in the brain that process smell. Research in animals has also suggested that prokineticin 2 and its receptor are involved in the movement (migration) of nerve cells that produce gonadotropin-releasing hormone (GnRH). GnRH controls the production of several other hormones that direct sexual development before birth and during puberty. These hormones are important for the normal function of the gonads (ovaries in women and testes in men).

Several additional functions of prokineticin 2 and its receptor have been discovered in studies with animals. These proteins help stimulate the movement of food through the intestine and are likely involved in the formation of new blood vessels (angiogenesis). They also play a role in coordinating daily (circadian) rhythms, such as the sleep-wake cycle and regular changes in body temperature. Prokineticin 2 and its receptor are active in a region of the brain called the suprachiasmatic nucleus (SCN), which acts as an internal clock that controls circadian rhythms.

Little is known about the functions of prokineticin 2 and its receptor in humans. These proteins are produced in many organs and tissues, including the small intestine, certain regions of the brain, and several hormone-producing (endocrine) tissues. Researchers believe that the functions of these proteins in humans may be similar to their functions in other animals.

Interactant

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