PROKR2 prokineticin receptor 2 [Homo sapiens (human)]
| Gene Symbol | PROKR2 |
| Entrez Gene ID | 128674 |
| Full Name | prokineticin receptor 2 |
| Synonyms | GPR73L1, GPR73b, GPRg2, KAL3, PKR2, dJ680N4.3 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
20 20p12.3 |
| Summary | Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor for prokineticins. The encoded protein is similar in sequence to GPR73, another G protein-coupled receptor for prokineticins. [provided by RefSeq]. |
| Disorder | MIM: 607123 Kallmann syndrome 3, 244200 (3) |
| mRNA | NM_144773, 30581162 |
| Protein | NP_658986, 21426829 |
| Product | prokineticin receptor 2 |
| RefSeq Status | REVIEWED |
| WP117 | GPCRs, Other |
Reactome
| REACT_14819 | Peptide ligand-binding receptors |
| REACT_21340 | GPCR ligand binding |
| REACT_19184 | GPCR downstream signaling |
| REACT_14828 | Class A/1 (Rhodopsin-like receptors) |
| REACT_18283 | G alpha (q) signalling events |
| REACT_14797 | Signaling by GPCR |
| Homo sapiens (human) | PROKR2 | NP_658986.1 |
| Pan troglodytes (chimpanzee) | PROKR2 | XP_001165973.1 |
| Canis lupus familiaris (dog) | PROKR2 | XP_851026.1 |
| Bos taurus (cattle) | PROKR2 | NP_777065.1 |
| Mus musculus (house mouse) | Prokr2 | NP_659193.2 |
| Rattus norvegicus (Norway rat) | Prokr2 | NP_620434.1 |
| Gallus gallus (chicken) | PROKR2 | XP_419334.2 |
| Danio rerio (zebrafish) | LOC798080 | XP_001338538.1 |
| ID | Name | Evidence |
| GO:0005886 | plasma membrane | EXP |
| GO:0005886 | plasma membrane | TAS |
| GO:0016021 | integral to membrane | IEA |
Function
| ID | Name | Evidence |
| GO:0004872 | receptor activity | IEA |
| GO:0004930 | G-protein coupled receptor activity | IEA |
| GO:0004983 | neuropeptide Y receptor activity | IEA |
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