Sequence in raw or FASTA format:
PROKR2 prokineticin receptor 2 [Homo sapiens (human)]
|Entrez Gene ID||128674|
|Full Name||prokineticin receptor 2|
|Synonyms||GPR73L1, GPR73b, GPRg2, HH3, KAL3, PKR2, dJ680N4.3|
|General protein information||
|Organism||Homo sapiens (human)|
|Summary||Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor for prokineticins. The encoded protein is similar in sequence to GPR73, another G protein-coupled receptor for prokineticins. [provided by RefSeq, Jul 2008].|
Kallmann syndrome 3, 244200 (3)
|REACT_19184||GPCR downstream signaling|
|REACT_18283||G alpha (q) signalling events|
|REACT_14797||Signaling by GPCR|
|REACT_14819||Peptide ligand-binding receptors|
|REACT_14828||Class A/1 (Rhodopsin-like receptors)|
|REACT_21340||GPCR ligand binding|
|REACT_120966||Gastrin-CREB signalling pathway via PKC and MAPK|
|Homo sapiens (human)||PROKR2||NP_658986.1|
|Pan troglodytes (chimpanzee)||PROKR2||XP_001166012.1|
|Canis lupus familiaris (dog)||PROKR2||XP_851026.1|
|Bos taurus (cattle)||PROKR2||NP_777065.1|
|Mus musculus (house mouse)||Prokr2||NP_659193.3|
|Rattus norvegicus (Norway rat)||Prokr2||NP_620434.1|
|Gallus gallus (chicken)||PROKR2||NP_001138701.1|
|Danio rerio (zebrafish)||LOC798231||NP_001166878.1|
|Xenopus (Silurana) tropicalis (western clawed frog)||prokr2||XP_002931802.1|
|GO:0007218||neuropeptide signaling pathway||IEA|
|GO:0016021||integral component of membrane||IEA|
|GO:0004983||neuropeptide Y receptor activity||IEA|
What is the normal function of the PROKR2 gene?
The PROKR2 gene provides instructions for making a protein called prokineticin receptor 2. This receptor interacts with a protein called prokineticin 2 (produced from the PROK2 gene). On the cell surface, prokineticin 2 attaches to the receptor like a key in a lock. When the two proteins are connected, they trigger a series of chemical signals within the cell that regulate various cell functions.
In animal studies, prokineticin 2 and its receptor have been shown to play a role in the normal development of the olfactory bulb, which is a group of nerve cells in the brain that process smell. Research in animals has also suggested that prokineticin 2 and its receptor are involved in the movement (migration) of nerve cells that produce gonadotropin-releasing hormone (GnRH). GnRH controls the production of several other hormones that direct sexual development before birth and during puberty. These hormones are important for the normal function of the gonads (ovaries in women and testes in men).
Several additional functions of prokineticin 2 and its receptor have been discovered in studies with animals. These proteins help stimulate the movement of food through the intestine and are likely involved in the formation of new blood vessels (angiogenesis). They also play a role in coordinating daily (circadian) rhythms, such as the sleep-wake cycle and regular changes in body temperature. Prokineticin 2 and its receptor are active in a region of the brain called the suprachiasmatic nucleus (SCN), which acts as an internal clock that controls circadian rhythms.
Little is known about the functions of prokineticin 2 and its receptor in humans. These proteins are produced in many organs and tissues, including the small intestine, certain regions of the brain, and several hormone-producing (endocrine) tissues. Researchers believe that the functions of these proteins in humans may be similar to their functions in other animals.
Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.