PIGU phosphatidylinositol glycan anchor biosynthesis, class U [Homo sapiens (human)]
| Gene Symbol | PIGU |
| Entrez Gene ID | 128869 |
| Full Name | phosphatidylinositol glycan anchor biosynthesis, class U |
| Synonyms | CDC91L1, GAB1, MGC40420 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
20 20q11.22 |
| Summary | The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Cdc91, a predicted integral membrane protein that may function in cell division control. The protein encoded by this gene is the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins. [provided by RefSeq]. COMPLETENESS: complete on the 3' end. |
| Disorder | MIM: 608528 |
| mRNA | NM_080476, 52426746 |
| Protein | NP_536724, 17998700 |
| Product | phosphatidylinositol glycan anchor biosynthesis class U protein |
| RefSeq Status | REVIEWED |
| hsa00563 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis |
| hsa01100 | Metabolic pathways |
Reactome
| REACT_17015 | Metabolism of proteins |
| REACT_1830 | Attachment of GPI anchor to uPAR |
| REACT_22161 | Post-translational protein modification |
| REACT_1853 | Post-translational modification: synthesis of GPI-anchored proteins |
| Homo sapiens (human) | PIGU | NP_536724.1 |
| Pan troglodytes (chimpanzee) | PIGU | XP_514597.2 |
| Canis lupus familiaris (dog) | PIGU | XP_542970.2 |
| Bos taurus (cattle) | PIGU | XP_873769.3 |
| Mus musculus (house mouse) | Pigu | NP_001004721.1 |
| Rattus norvegicus (Norway rat) | Pigu | NP_853668.1 |
| Gallus gallus (chicken) | PIGU | XP_417310.2 |
| Danio rerio (zebrafish) | pigu | XP_686298.1 |
| Drosophila melanogaster (fruit fly) | CG13089 | NP_609238.1 |
| Caenorhabditis elegans | T22C1.3 | NP_492189.2 |
| Arabidopsis thaliana (thale cress) | AT1G63110 | NP_850969.2 |
| Arabidopsis thaliana (thale cress) | AT1G12730 | NP_563912.1 |
| ID | Name | Evidence |
| GO:0006501 | C-terminal protein lipidation | TAS |
| GO:0006506 | GPI anchor biosynthetic process | IDA |
| GO:0016255 | attachment of GPI anchor to protein | EXP |
| GO:0016255 | attachment of GPI anchor to protein | TAS |
| GO:0043687 | post-translational protein modification | TAS |
| GO:0044267 | cellular protein metabolic process | TAS |
| GO:0046425 | regulation of JAK-STAT cascade | IDA |
Component
| ID | Name | Evidence |
| GO:0005783 | endoplasmic reticulum | IEA |
| GO:0005789 | endoplasmic reticulum membrane | TAS |
| GO:0005886 | plasma membrane | IDA |
| GO:0016021 | integral to membrane | IEA |
| GO:0030176 | integral to endoplasmic reticulum membrane | IC |
| GO:0042765 | GPI-anchor transamidase complex | IMP |
Function
| ID | Name | Evidence |
| GO:0003923 | GPI-anchor transamidase activity | TAS |
| GO:0034235 | GPI anchor binding | TAS |
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