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Sequence in raw or FASTA format:


Blast Method:


COMP cartilage oligomeric matrix protein [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000095 Homo sapiens cartilage oligomeric matrix protein (COMP), mRNA. GenEZ ORF Cloning In-stock $639.00 $590.00 15

*Business Day

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Gene Symbol COMP
Entrez Gene ID 1311
Full Name cartilage oligomeric matrix protein
Synonyms EDM1, EPD1, MED, PSACH, THBS5
General protein information
Preferred Names
cartilage oligomeric matrix protein
cartilage oligomeric matrix protein
pseudoachondroplasia (epiphyseal dysplasia 1, multiple)
cartilage oligomeric matrix protein(pseudoachondroplasia, epiphyseal dysplasia 1, multiple)
cartilage oligomeric matrix protein (pseudoachondroplasia, epiphyseal dysplasia 1, multiple)
Gene Type protein-coding
Organism Homo sapiens (human)



Summary The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Mutations can cause the osteochondrodysplasias pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED). [provided by RefSeq, Jul 2008].

MIM: 600310

Pseudoachondroplasia, 177170 (3); Epiphyseal dysplasia, multiple 1,

mRNA Protein Product Sequence Price Select
NM_000095, 40217842 NP_000086, 40217843 cartilage oligomeric matrix protein precursor ORF Sequence $490.00
hsa04510Focal adhesion
hsa04512ECM-receptor interaction
hsa04151PI3K-Akt signaling pathway
REACT_13552Integrin cell surface interactions
REACT_118779Extracellular matrix organization
REACT_163906ECM proteoglycans
Homo sapiens (human)COMPNP_000086.2
Pan troglodytes (chimpanzee)COMPNP_001092035.1
Macaca mulatta (Rhesus monkey)COMPXP_001115565.1
Canis lupus familiaris (dog)COMPXP_533869.2
Bos taurus (cattle)COMPNP_001159989.1
Mus musculus (house mouse)CompNP_057894.2
Rattus norvegicus (Norway rat)CompNP_036966.1
Gallus gallus (chicken)COMPXP_418238.2
Danio rerio (zebrafish)im:7154332XP_002663752.3
Drosophila melanogaster (fruit fly)TspNP_523495.2
Xenopus (Silurana) tropicalis (western clawed frog)compXP_002940251.2
GO:0001501skeletal system developmentTAS
GO:0003417growth plate cartilage developmentIEA
GO:0006915apoptotic processIEA
GO:0007155cell adhesionIEA
GO:0009887organ morphogenesisTAS
GO:0030198extracellular matrix organizationTAS
GO:0043066negative regulation of apoptotic processIDA
GO:0060173limb developmentIDA
GO:0005576extracellular regionTAS
GO:0005578proteinaceous extracellular matrixIEA
GO:0005615extracellular spaceIDA
GO:0031012extracellular matrixIDA
GO:0070062extracellular vesicular exosomeIDA
GO:0002020protease bindingIPI
GO:0005201extracellular matrix structural constituentIEA
GO:0005509calcium ion bindingIDA
GO:0005515protein bindingIPI
GO:0005518collagen bindingIDA
GO:0008201heparin bindingIDA
GO:0043395heparan sulfate proteoglycan bindingIDA
GeneCards COMP
UniProt P49747
Vega OTTHUMG00000169318
MIM 600310
Ensembl ENSG00000105664
HGNC 2227
HPRD 02632

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the COMP gene?

The COMP gene provides the instructions for making the COMP protein. This protein is found in the extracellular matrix, which is an intricate lattice of proteins and other molecules that forms in the spaces between cells. Specifically, the COMP protein is located in the extracellular matrix surrounding the cells that make up ligaments and tendons, and near cartilage-forming cells (chondrocytes). Chondrocytes play an important role in bone formation (osteogenesis). In the bones of the spine, hips, and limbs, the process of osteogenesis starts with the formation of cartilage, which is then converted into bone.

The normal function of the COMP protein is not fully known. It is believed to play a role in cell growth and division (proliferation) and the self-destruction of cells (apoptosis), as well as in the regulation of cell movement and attachment. Research has also shown that the COMP protein binds strongly to calcium.


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