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COMP cartilage oligomeric matrix protein [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu19189 NM_000095 Homo sapiens cartilage oligomeric matrix protein (COMP), mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu19189C NM_000095 Homo sapiens cartilage oligomeric matrix protein (COMP), mRNA. Customized vector In-stock 5-7 $149.00

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Gene Symbol COMP
Entrez Gene ID 1311
Full Name cartilage oligomeric matrix protein
Synonyms EDM1, EPD1, MED, PSACH, THBS5
General protein information
Preferred Names
cartilage oligomeric matrix protein
Names
cartilage oligomeric matrix protein
TSP5
thrombospondin-5
pseudoachondroplasia (epiphyseal dysplasia 1, multiple)
cartilage oligomeric matrix protein(pseudoachondroplasia, epiphyseal dysplasia 1, multiple)
cartilage oligomeric matrix protein (pseudoachondroplasia, epiphyseal dysplasia 1, multiple)
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

19

19p13.1

Summary The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Mutations can cause the osteochondrodysplasias pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED). [provided by RefSeq, Jul 2008].
Disorder

MIM: 600310

Pseudoachondroplasia, 177170 (3); Epiphyseal dysplasia, multiple 1,

mRNA Protein Product Sequence Price Select
NM_000095, 40217842 NP_000086, 40217843 cartilage oligomeric matrix protein precursor ORF Sequence $490.00
KEGG
hsa04510Focal adhesion
hsa04512ECM-receptor interaction
hsa05144Malaria
hsa04145Phagosome
hsa04151PI3K-Akt signaling pathway
Reactome
REACT_13552Integrin cell surface interactions
REACT_118779Extracellular matrix organization
REACT_163906ECM proteoglycans
Homo sapiens (human)COMPNP_000086.2
Pan troglodytes (chimpanzee)COMPNP_001092035.1
Macaca mulatta (Rhesus monkey)COMPXP_001115565.1
Canis lupus familiaris (dog)COMPXP_533869.2
Bos taurus (cattle)COMPNP_001159989.1
Mus musculus (house mouse)CompNP_057894.2
Rattus norvegicus (Norway rat)CompNP_036966.1
Gallus gallus (chicken)COMPXP_418238.2
Danio rerio (zebrafish)im:7154332XP_002663752.3
Drosophila melanogaster (fruit fly)TspNP_523495.2
Xenopus (Silurana) tropicalis (western clawed frog)compXP_002940251.2
Process
IDNameEvidence
GO:0001501skeletal system developmentTAS
GO:0003417growth plate cartilage developmentIEA
GO:0006915apoptotic processIEA
GO:0007155cell adhesionIEA
GO:0009887organ morphogenesisTAS
GO:0030198extracellular matrix organizationTAS
GO:0043066negative regulation of apoptotic processIDA
GO:0060173limb developmentIDA
Component
IDNameEvidence
GO:0005576extracellular regionTAS
GO:0005578proteinaceous extracellular matrixIEA
GO:0005615extracellular spaceIDA
GO:0031012extracellular matrixIDA
GO:0070062extracellular vesicular exosomeIDA
Function
IDNameEvidence
GO:0002020protease bindingIPI
GO:0005201extracellular matrix structural constituentIEA
GO:0005509calcium ion bindingIDA
GO:0005515protein bindingIPI
GO:0005518collagen bindingIDA
GO:0008201heparin bindingIDA
GO:0043395heparan sulfate proteoglycan bindingIDA
GeneCards COMP
PDB 3FBY
UniProt P49747
Vega OTTHUMG00000169318
MIM 600310
Ensembl ENSG00000105664
HGNC 2227
HPRD 02632

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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