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COMP cartilage oligomeric matrix protein [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000095 Homo sapiens cartilage oligomeric matrix protein (COMP), mRNA. GenEZ ORF Cloning In-stock $639.00 $590.00 15

*Business Day

Related Services

Gene Symbol COMP
Entrez Gene ID 1311
Full Name cartilage oligomeric matrix protein
Synonyms EDM1, EPD1, MED, MGC131819, MGC149768, PSACH, THBS5
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

19

19p13.1

Summary The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Mutations can cause the osteochondrodysplasias pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED). [provided by RefSeq, Jul 2008].
Disorder

MIM: 600310

Pseudoachondroplasia, 177170 (3); Epiphyseal dysplasia, multiple 1,

mRNA Protein Product Sequence Price Select
NM_000095, 40217842 NP_000086, 40217843 cartilage oligomeric matrix protein precursor ORF Sequence $490.00
KEGG
hsa04512ECM-receptor interaction
hsa04145Phagosome
hsa04510Focal adhesion
hsa05144Malaria
hsa04350TGF-beta signaling pathway
hsa04151PI3K-Akt signaling pathway
WikiPathways
WP306Focal Adhesion
Homo sapiens (human)COMPNP_000086.2
Pan troglodytes (chimpanzee)COMPNP_001092035.1
Macaca mulatta (Rhesus monkey)COMPXP_001115565.1
Canis lupus familiaris (dog)COMPXP_533869.2
Bos taurus (cattle)COMPNP_001159989.1
Mus musculus (house mouse)CompNP_057894.2
Gallus gallus (chicken)COMPXP_418238.2
Danio rerio (zebrafish)im:7154332XP_002663752.2
Drosophila melanogaster (fruit fly)TspNP_523495.2
GeneCards COMP
PDB 3FBY
UniProt P49747
MIM 600310
Ensembl ENSG00000105664
HGNC 2227
HPRD 02632

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
cartilage oligomeric matrix protein
Names
cartilage oligomeric matrix protein
TSP5
thrombospondin-5
pseudoachondroplasia (epiphyseal dysplasia 1, multiple)
cartilage oligomeric matrix protein(pseudoachondroplasia, epiphyseal dysplasia 1, multiple)
cartilage oligomeric matrix protein (pseudoachondroplasia, epiphyseal dysplasia 1, multiple)

Interactant



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